WORKLIST ENTRIES (1):

TRNSRECEPTRP View alignment     Transient receptor potential family signature
 Type of fingerprint: COMPOUND with 3  elements
Links:
   PRINTS; PR00167 CACHANNEL
   PRINTS; PR01642 TRPCHANNEL1; PR01643 TRPCHANNEL2; PR01644 TRPCHANNEL3
   PRINTS; PR01645 TRPCHANNEL4; PR01646 TRPCHANNEL5; PR01647 TRPCHANNEL6
   PRINTS; PR01648 TRPCHANNEL7
   INTERPRO; IPR002153

 Creation date 04-MAR-1999; UPDATE 10-JUN-1999

   1. ZHU, X., JIANG, M., PEYTON, M., BOULAY, G., HURST, R., STEFANI, E. 
   AND BIRNBAUMER, L.
   Trp, a novel mammalian gene family essential for agonist-activated 
   capacitative Ca2+ entry.
   CELL 85 661-671 (1996).

   2. BOULAY, G., ZHU, X., PEYTON, M., JIANG, M., HURST, R., STEFANI, E. 
   AND BIRNBAUMER, L.
   Cloning and expression of a novel mammalian homolog of Drosophila transient 
   receptor potential (Trp) involved in calcium entry secondary to activation 
   of receptors coupled by the Gq class of G protein.
   J.BIOL.CHEM. 272 29672-29680 (1997).

   Transient receptor potential (Trp) and related proteins are thought to be
   Ca2+ ion channel subunits that mediate capacitative Ca2+ entry in response 
   to a range of external and internal cell stimuli. Such Ca2+ entry is thought 
   to be an essential component of cellular responses to many hormones and
   growth factors, and acts to replenish intracellular Ca2+ stores that have
   been emptied through the action of inositol triphosphate (IP3) and other 
   agents. In non-excitable cells, i.e. those that lack voltage-gated Ca2+
   channels, such as hepatocytes, this mode of Ca2+ entry is thought to be an
   important step in generating the oscillations of intracellular Ca2+
   concentration that characterise their response to stimulatory agents [1].
  
   Studies on the visual transduction system in Drosophila led to the molecular
   cloning of Trp and the cDNA of a related protein, Trp-like, which show
   similarity to voltage gated Ca2+ channels in the regions known as S3 through
   S6, including the S5-S6 linker that forms the ion-selective channel pore [2].
   This provided evidence that Trp and/or related proteins might form mammalian
   capacitative Ca2+ entry channels. They have varying lengths (usually 800-1000
   amino acid residues), and hydropathy analyses suggest that they have six or
   more transmebrane (TM) regions, flanked by cytosolic N- and C-termini.
   
   TRNSRECEPTRP is a 3-element fingerprint that provides a signature for the
   transient receptor potential family and related proteins. The fingerprint
   was derived from an initial alignment of 26 sequences: the motifs were
   drawn from the central hydrophobic region of the molecules containing the
   putative TM domains. Two iterations on OWL31.1 were required to reach 
   convergence, at which point a true set comprising 27 sequences was 
   identified. A single partial match was also found, a TRP-like protein 
   fragment from Mus musculus that matches motifs 1 and 2.
  
   An update on SPTR37_9f identified a true set of 17 sequences.

  SUMMARY INFORMATION
     17 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    3|  17   17   17  
    2|   0    0    0  
   --+----------------
     |   1    2    3  

True positives..
 O62852         O35119         P79100         O18784         
 O18785         O35722         Q61056         TRP1_HUMAN     
 O44872         Q61143         O46129         Q13507         
 Q94447         O62826         TRPL_DROME     TRP_DROME      
 YN52_CAEEL     


  PROTEIN TITLES
   O62852           CAPACITATIVE CALCIUM ENTRY CHANNEL 2 - ORYCTOLAGUS CUNICULUS
   O35119           TRANSIENT RECEPTOR POTENTIAL - RATTUS NORVEGICUS (RAT).
   P79100           CAPACITATIVE CALCIUM ENTRY CHANNEL 1 (CAPACITATIVE CALCIUM E
   O18784           TRP-1A - BOS TAURUS (BOVINE).
   O18785           TRP-1B - BOS TAURUS (BOVINE).
   O35722           TRANSIENT RECEPTOR PROTEIN 1 (MTRP1 BETA) - MUS MUSCULUS (MO
   Q61056           TRANSIENT RECEPTOR PROTEIN 1 (FRAGMENT) - MUS MUSCULUS (MOUS
   TRP1_HUMAN       TRP-1 PROTEIN (TRPC1 PROTEIN) - HOMO SAPIENS (HUMAN).
   O44872           R06B10.4 PROTEIN - CAENORHABDITIS ELEGANS.
   Q61143           CALCIUM ENTRY CHANNEL - MUS MUSCULUS (MOUSE).
   O46129           TRP-LIKE PROTEIN - LOLIGO FORBESI (NORTHERN EUROPEAN SQUID).
   Q13507           TRANSIENT RECEPTOR POTENTIAL RELATED CHANNEL 3 PROTEIN - HOM
   Q94447           TRP PROTEIN - CALLIPHORA VICINA (BLUE BLOWFLY) (CALLIPHORA E
   O62826           TYROSINE-RELATED PROTEIN 2 - BOS TAURUS (BOVINE).
   TRPL_DROME       TRANSIENT-RECEPTOR-POTENTIAL LIKE PROTEIN - DROSOPHILA MELAN
   TRP_DROME        TRANSIENT-RECEPTOR-POTENTIAL PROTEIN - DROSOPHILA MELANOGAST
   YN52_CAEEL       HYPOTHETICAL 95.6 KD PROTEIN ZC21.2 IN CHROMOSOME III - CAEN

SCAN HISTORY OWL31_1 2 200 NSINGLE SPTR37_9f 2 18 NSINGLE INITIAL MOTIF SETS TRNSRECEPTRP1 Length of motif = 22 Motif number = 1 Transient receptor potential protein motif I - 1 PCODE ST INT GVYNVTMVIVLLNMLIAMINSS MMU49069 708 708 GVYNVTMVIVLLNMLIAMINSS AF080394 709 709 GIYNVTMVVVLLNMLIAMINSS HSY13758 652 652 GSYSVINIIVLLNMLIAMMSNS TRP_DROME 643 643 GSYSVINIIVLLNMLIAMMSNS DROTRPC 642 642 GSYSVINIIVLLNMLIAMMSNS CVTRP 640 640 GTYNVISLVVLLNMLIAMMNNS AB008889 580 580 GTYNVISLVVLLNMLIAMMNNS BTCCE1 604 604 GTYNVISLVVLLNMLIAMMNNS MMU50921 602 602 GTYNVISLVVLLNMLIAMMNNS MMU50922 602 602 GTYNVISLVVLLNMLIAMMNNS AF029983 606 606 GTYNVISLVVLLNMLIAMMNNS MMAJ6204 606 606 GTYNVISLVVLLNMLIAMMNNS OCAJ6203 606 606 GTYNVISLVVLLNMLIAMMNNS AF029983 606 606 GTYNVISLVVLLNMLIAMMNNS BTA224862 91 91 GIFTIVMVIVLLNMLIAMITNS BTA6304 164 164 GTYNVVVVIVLTKLLVAMLHKS AF012900 627 627 GTYNVVVVIVLTKLLVAMLHKS TRP1_HUMAN 627 627 GTYNVVVVIVLTKLLVAMLHKS MMU73625 643 643 GTYNVVVVIVLTKLLVAMLHKS AF012901 593 593 GTYNVVVVIVLTKLLVAMLHKS MMU95167 609 609 GTYNVVVVIVLTKLLVAMLHKS I38361 644 644 GSYSVINVIVLLNLLIAMMSNS TRPL_DROME 650 650 GIYNVTMVVVLLNMLIAMINSS JC5807 634 634 GSYSMIAIIILLNLLIAMMSNS LFAJ3320 606 606 IMYHCTSIIVLLNMLIAMMSHS YN52_CAEEL 662 662 TRNSRECEPTRP2 Length of motif = 14 Motif number = 2 Transient receptor potential protein motif II - 1 PCODE ST INT FQEIEDDADVEWKF MMU49069 730 0 FQEIEDDADVEWKF AF080394 731 0 YQEIEDDSDVEWKF HSY13758 674 0 YQIISERADTEWKF TRP_DROME 665 0 YQIISERADTEWKF DROTRPC 664 0 YQIISERADVEWKF CVTRP 662 0 YQLIADHADIEWKF AB008889 602 0 YQLIADHADIEWKF BTCCE1 626 0 YQLIADHADIEWKF MMU50921 624 0 YQLIADHADIEWKF MMU50922 624 0 YQLIADHADIEWKF AF029983 628 0 YQLIADHADIEWKF MMAJ6204 628 0 YQLIADHADIEWKF OCAJ6203 628 0 YQLIADHADIEWKF AF029983 628 0 YQLIADHADIEWKF BTA224862 113 0 FQKIEDAADVEWKF BTA6304 186 0 FQLIANHEDKEWKF AF012900 649 0 FQLIANHEDKEWKF TRP1_HUMAN 649 0 FQLIANHEDKEWKF MMU73625 665 0 FQLIANHEDKEWKF AF012901 615 0 FQLIANHEDKEWKF MMU95167 631 0 FQLIANHEDKEWKF I38361 666 0 YAMIDEHSDTEWKF TRPL_DROME 672 0 YQEIEDDSDVEWKF JC5807 656 0 YQLIYSQADEEWKF LFAJ3320 628 0 FQIINDHADLEWKF YN52_CAEEL 684 0 TRNSRECEPTRP3 Length of motif = 14 Motif number = 3 Transient receptor potential protein motif III - 1 PCODE ST INT TLPVPFNLVPSPKS MMU49069 758 14 TLPVPFNLVPSPKS AF080394 759 14 TLPPPFSLVPSPKS HSY13758 702 14 TIPPPFNLCPNMKM TRP_DROME 693 14 TIPPPFNLCPNMKM DROTRPC 692 14 TVPPPFNMFPSVKL CVTRP 690 14 TLPTPFNVIPSPKS AB008889 630 14 TLPTPFNVIPSPKS BTCCE1 654 14 TLPTPFNVIPSPKS MMU50921 652 14 TLPTPFNVIPSPKS MMU50922 652 14 TLPPPFNIIPSPKS AF029983 656 14 TLPPPFNIIPSPKS MMAJ6204 656 14 TLPPPFNIIPSPKS OCAJ6203 656 14 TLPPPFNIIPSPKS AF029983 656 14 TLPTPFNVIPSPKS BTA224862 141 14 TLPVPFNILPSPKA BTA6304 214 14 TLPPPFNIIPSPKT AF012900 677 14 TLPPPFNIIPSPKT TRP1_HUMAN 677 14 TLPPPFNIIPSPKT MMU73625 693 14 TLPPPFNIIPSPKT AF012901 643 14 TLPPPFNIIPSPKT MMU95167 659 14 TLPPPFNIIPSPKT I38361 694 14 TLPPPFNVLPSVKW TRPL_DROME 700 14 TLPPPLVPCPKSFV JC5807 684 14 TVPPPFNIIPSPKS LFAJ3320 656 14 SLPPPFNIIVTPKS YN52_CAEEL 712 14 FINAL MOTIF SETS TRNSRECEPTRP1 Length of motif = 22 Motif number = 1 Transient receptor potential protein motif I - 2 PCODE ST INT GTYNVISLVVLLNMLIAMMNNS O62852 606 606 GTYNVISLVVLLNMLIAMMNNS O35119 580 580 GTYNVISLVVLLNMLIAMMNNS P79100 604 604 GTYNVVVVIVLTKLLVAMLHKS O18784 627 627 GTYNVVVVIVLTKLLVAMLHKS O18785 593 593 GTYNVVVVIVLTKLLVAMLHKS O35722 609 609 GTYNVVVVIVLTKLLVAMLHKS Q61056 627 627 GTYNVVVVIVLTKLLVAMLHKS TRP1_HUMAN 627 627 GSYCCCSIIVLLNMLIAMMSNS O44872 660 660 GVYNVTMVIVLLNMLIAMINSS Q61143 708 708 GSYSMIAIIILLNLLIAMMSNS O46129 606 606 GIYNVTMVVVLLNMLIAMINSS Q13507 652 652 GSYSVINIIVLLNMLIAMMSNS Q94447 640 640 GIFTIVMVIVLLNMLIAMITNS O62826 164 164 GSYSVINVIVLLNLLIAMMSNS TRPL_DROME 650 650 GSYSVINIIVLLNMLIAMMSNS TRP_DROME 643 643 IMYHCTSIIVLLNMLIAMMSHS YN52_CAEEL 662 662 TRNSRECEPTRP2 Length of motif = 14 Motif number = 2 Transient receptor potential protein motif II - 2 PCODE ST INT YQLIADHADIEWKF O62852 628 0 YQLIADHADIEWKF O35119 602 0 YQLIADHADIEWKF P79100 626 0 FQLIANHEDKEWKF O18784 649 0 FQLIANHEDKEWKF O18785 615 0 FQLIANHEDKEWKF O35722 631 0 FQLIANHEDKEWKF Q61056 649 0 FQLIANHEDKEWKF TRP1_HUMAN 649 0 YQYISDQADIEWKF O44872 682 0 FQEIEDDADVEWKF Q61143 730 0 YQLIYSQADEEWKF O46129 628 0 YQEIEDDSDVEWKF Q13507 674 0 YQIISERADVEWKF Q94447 662 0 FQKIEDAADVEWKF O62826 186 0 YAMIDEHSDTEWKF TRPL_DROME 672 0 YQIISERADTEWKF TRP_DROME 665 0 FQIINDHADLEWKF YN52_CAEEL 684 0 TRNSRECEPTRP3 Length of motif = 14 Motif number = 3 Transient receptor potential protein motif III - 2 PCODE ST INT TLPPPFNIIPSPKS O62852 656 14 TLPTPFNVIPSPKS O35119 630 14 TLPTPFNVIPSPKS P79100 654 14 TLPPPFNIIPSPKT O18784 677 14 TLPPPFNIIPSPKT O18785 643 14 TLPPPFNIIPSPKT O35722 659 14 TLPPPFNIIPSPKT Q61056 677 14 TLPPPFNIIPSPKT TRP1_HUMAN 677 14 TLPPPFNIVPSPKS O44872 710 14 TLPVPFNLVPSPKS Q61143 758 14 TVPPPFNIIPSPKS O46129 656 14 TLPPPFSLVPSPKS Q13507 702 14 TVPPPFNMFPSVKL Q94447 690 14 TLPVPFNILPSPKA O62826 214 14 TLPPPFNVLPSVKW TRPL_DROME 700 14 TIPPPFNLCPNMKM TRP_DROME 693 14 SLPPPFNIIVTPKS YN52_CAEEL 712 14

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