WORKLIST ENTRIES (1):
TNFACTORR9 View alignment Tumour necrosis factor receptor 9 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3
PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6
PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01956 TNFACTORR10
PRINTS; PR01961 TNFACTORR11; PR01962 TNFACTORR12; PR01963 TNFACTORR13B
PRINTS; PR01964 TNFACTORR13C; PR01965 TNFACTORR14; PR01966 TNFACTORR16
PRINTS; PR01967 TNFACTORR17; PR01968 TNFACTORR18; PR01969 TNFACTORR19
PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25
PRINTS; PR01973 TNFACTORR27
PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B
PDB; 1D0J 3Dinfo
SCOP; 1D0J
CATH; 1D0J
MIM; 602250
Creation date 23-APR-2008
1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
7. SCHWARZ, H., BLANCO, F., VON KEMPIS, J., VALBRACHT, J. AND LOTZ, M.
ILA, a member of the human nerve growth factor/tumor necrosis factor
receptor family, regulates T-lymphocyte proliferation and survival.
BLOOD 87 2839-2845 (1996).
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
TNF receptor 9 (also known as ILA and CD137 antigen) is expressed by
activated T and B lymphocytes and monocytes. Stimulation of the receptor
inhibits proliferation of activated T lymphocytes and induces programmed
cell death [7].
TNFACTORR9 is a 3-element fingerprint that provides a signature for tumour
necrosis factor receptor 9. The fingerprint was derived from an initial
alignment of 2 sequences: the motifs were drawn from conserved regions in
the C-terminal half of the alignment, focusing on those sections that
characterise TNF receptor 9 but distinguish it from other TNF receptor
subtypes - motif 1 lies partially in the transmembrane domain and partially
within the C-terminal cytoplasmic region; and motifs 2 and 3 reside within
the C-terminal cytoplasmic region. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 7
sequences was identified. Three partial matches were also found, all
of which fail to match motif 1: Q8R037_MOUSE is a translated cDNA from
mouse; and A9YYF0_MACFA and A9YYF1_MACFA are receptor variants from crab-
eating macaque.
SUMMARY INFORMATION
7 codes involving 3 elements
3 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 7 7 7
2| 0 3 3
--+----------------
| 1 2 3
True positives..
Q3U3R1_MOUSE TNR9_MOUSE TNR9_HUMAN A9YYE7_MACFA
Q3ZC74_BOVIN Q4V895_RAT Q4W8J3_RAT
Subfamily: Codes involving 2 elements
Subfamily True positives..
A9YYF0_MACFA A9YYF1_MACFA Q8R037_MOUSE
PROTEIN TITLES
Q3U3R1_MOUSE NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-lengt
TNR9_MOUSE Tumor necrosis factor receptor superfamily member 9 precurso
TNR9_HUMAN Tumor necrosis factor receptor superfamily member 9 precurso
A9YYE7_MACFA CD137 - Macaca fascicularis (Crab eating macaque) (Cynomolgu
Q3ZC74_BOVIN Similar to tumor necrosis factor receptor superfamily, membe
Q4V895_RAT Similar to T-cell antigen 4-1BB-mouse - Rattus norvegicus (R
Q4W8J3_RAT 4-1BB homolog - Rattus norvegicus (Rat).
A9YYF0_MACFA CD137 variant - Macaca fascicularis (Crab eating macaque) (C
A9YYF1_MACFA CD137 variant - Macaca fascicularis (Crab eating macaque) (C
Q8R037_MOUSE Tumor necrosis factor receptor superfamily, member 9 (Secret
SCAN HISTORY
SPTR55_38f 2 300 NSINGLE
INITIAL MOTIF SETS
TNFACTORR91 Length of motif = 14 Motif number = 1
Tumour necrosis factor receptor 9 motif I - 1
PCODE ST INT
IFITLLFSVLKWIR TNR9_MOUSE 202 202
FFLTLRFSVVKRGR TNR9_HUMAN 204 204
TNFACTORR92 Length of motif = 15 Motif number = 2
Tumour necrosis factor receptor 9 motif II - 1
PCODE ST INT
IFKQPFKKTTGAAQE TNR9_MOUSE 221 5
IFKQPFMRPVQTTQE TNR9_HUMAN 223 5
TNFACTORR93 Length of motif = 11 Motif number = 3
Tumour necrosis factor receptor 9 motif III - 1
PCODE ST INT
DACSCRCPQEE TNR9_MOUSE 237 1
DGCSCRFPEEE TNR9_HUMAN 239 1
FINAL MOTIF SETS
TNFACTORR91 Length of motif = 14 Motif number = 1
Tumour necrosis factor receptor 9 motif I - 2
PCODE ST INT
IFITLLFSVLKWIR Q3U3R1_MOUSE 202 202
IFITLLFSVLKWIR TNR9_MOUSE 202 202
FFLTLRFSVVKRGR TNR9_HUMAN 204 204
FFLVLRFSVVKRSR A9YYE7_MACFA 203 203
SFLVLRFSVIKQGR Q3ZC74_BOVIN 203 203
IFIILWFSVPKWLR Q4V895_RAT 204 204
IFIILWFSVPKWLR Q4W8J3_RAT 204 204
TNFACTORR92 Length of motif = 15 Motif number = 2
Tumour necrosis factor receptor 9 motif II - 2
PCODE ST INT
IFKQPFKKTTGAAQE Q3U3R1_MOUSE 221 5
IFKQPFKKTTGAAQE TNR9_MOUSE 221 5
IFKQPFMRPVQTTQE TNR9_HUMAN 223 5
IFKQPFMRPVQTTQE A9YYE7_MACFA 222 5
IFKQPFMRPVQTAQE Q3ZC74_BOVIN 222 5
IFKQPFKKAVRTAQE Q4V895_RAT 223 5
IFKQPFKKAVRTAQE Q4W8J3_RAT 223 5
TNFACTORR93 Length of motif = 11 Motif number = 3
Tumour necrosis factor receptor 9 motif III - 2
PCODE ST INT
DACSCRCPQEE Q3U3R1_MOUSE 237 1
DACSCRCPQEE TNR9_MOUSE 237 1
DGCSCRFPEEE TNR9_HUMAN 239 1
DGCSCRFPEEE A9YYE7_MACFA 238 1
DACSCRFPEEE Q3ZC74_BOVIN 238 1
DACSCRFPEEE Q4V895_RAT 239 1
DACSCRFPEEE Q4W8J3_RAT 239 1
User query: Display/Full Code "TNFACTORR9"