WORKLIST ENTRIES (1):

TNFACTORR19 View alignment      Tumour necrosis factor receptor 19 signature
 Type of fingerprint: COMPOUND with 4  elements
Links:
   PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3
   PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6
   PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9
   PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01962 TNFACTORR12
   PRINTS; PR01963 TNFACTORR13B; PR01964 TNFACTORR13C; PR01965 TNFACTORR14
   PRINTS; PR01966 TNFACTORR16; PR01967 TNFACTORR17; PR01968 TNFACTORR18
   PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25
   PRINTS; PR01973 TNFACTORR27
   PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B
   MIM; 606122

 Creation date 25-JUN-2009

   1. ARMITAGE, R.
   Tumor necrosis factor receptor superfamily members and their ligands.
   CURR.OPIN.IMMUNOL. 6 407-413 (1994).

   2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
   LOETSCHER, H. AND LESSLAUER, W.
   Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
   complex: implications for TNF receptor activation.
   CELL 73 431-445 (1993).
  
   3. WU, H.
   Assembly of post-receptor signaling complexes for the tumor necrosis factor
   receptor superfamily.
   ADV.PROTEIN CHEM. 68 225-279 (2004).

   4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
   The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
   CELL 104 487-501 (2001).

   5. GRAVESTEIN, L. AND BORST, J.
   Tumor necrosis factor receptor family members in the immune system.
   SEMIN.IMMUNOL. 10 423-434 (1998).

   6. LOENEN, W.
   D27 and (TNFR) relatives in the immune system: their role in health and
   disease.
   SEMIN.IMMUNOL. 10 417-422 (1998).

   7. EBY, M., JASMIN, A., KUMAR, A., SHARMA, K. AND CHAUDHARY, P.
   TAJ, a novel member of the tumor necrosis factor receptor family, activates
   the c-Jun N-terminal kinase pathway and mediates caspase-independent cell 
   death.
   J.BIOL.CHEM. 275 15336-15342 (2000).

   8. PARK, J., YIU, G., KANEKO, S., WANG, J., CHANG, J., HE, X., GARCIA, K.,
   HE, Z.
   A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in 
   mediating the inhibitory activity of myelin inhibitors.
   NEURON 45 345-351 (2005).

   The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
   than 20 type-I transmembrane proteins. Family members are defined based on
   similarity in their extracellular domain - a region that contains many
   cysteine residues arranged in a specific repetitive pattern [1]. The
   cysteines allow formation of an extended rod-like structure, responsible for
   ligand binding [2].
  
   Upon receptor activation, different intracellular signalling complexes are
   assembled for different members of the TNFR superfamily, depending on their
   intracellular domains and sequences [3]. Activation of TNFRs can therefore
   induce a range of disparate effects, including cell proliferation,
   differentiation, survival, or apoptotic cell death, depending upon the
   receptor involved [4,5].
  
   TNFRs are widely distributed and play important roles in many crucial
   biological processes, such as lymphoid and neuronal development, innate and
   adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
   manipulate their signalling have potential roles in the prevention and
   treatment of many diseases, such as viral infections, coronary heart
   disease, transplant rejection, and immune disease [6].
  
   TNF receptor 19 (also known as toxicity and JNK inducer (TAJ) and TROY) is 
   highly expressed during embryonic development, where it may act as a
   regulator of cell activation and cell death [7]. In adult tissues, the
   receptor is expressed in the central nervous system, and may mediate the
   inhibitory effects of myelin upon axon regeneration [8].
  
   TNFACTORR19 is a 4-element fingerprint that provides a signature for tumour
   necrosis factor receptor 19. The fingerprint was derived from an initial
   alignment of 2 sequences: the motifs were drawn from conserved regions in 
   the N-terminal two thirds of the alignment, focusing on those sections that
   characterise TNF receptor 19 but distinguish it from other TNF receptor
   subtypes - motifs 1 and 2 lie within the extracellular N-terminal region,
   and motifs 3 and 4 reside within the intracellular C-terminal region. Two
   iterations on SPTR57_40f were required to reach convergence, at which point
   a true set comprising 11 sequences was identified. Three partial matches 
   were also found, B4E2I6_HUMAN, Q8BWR1_MOUSE and Q2HJB7_BOVIN, which are
   translated human, murine and bovine cDNA sequences that fail to match the
   full complement of motifs.

  SUMMARY INFORMATION
     11 codes involving  4 elements
      3 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    4|  11   11   11   11  
    3|   1    3    3    2  
    2|   0    0    0    0  
   --+---------------------
     |   1    2    3    4  

True positives..
 A8KA26_HUMAN   TNR19_HUMAN    B1AM40_HUMAN   A8KA09_HUMAN   
 Q80T13_MOUSE   TNR19_MOUSE    Q8BUM7_MOUSE   Q1KMU0_RAT     
 A1XGV6_CHICK   A2SWM6_CHICK   Q1ECV9_DANRE   
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 B4E2I6_HUMAN   Q8BWR1_MOUSE   Q2HJB7_BOVIN   


  PROTEIN TITLES
   A8KA26_HUMAN     cDNA FLJ78604, highly similar to Homo sapiens tumor necrosis
   TNR19_HUMAN      Tumor necrosis factor receptor superfamily member 19 - Homo 
   B1AM40_HUMAN     Tumor necrosis factor receptor superfamily, member 19 - Homo
   A8KA09_HUMAN     cDNA FLJ76973, highly similar to Homo sapiens tumor necrosis
   Q80T13_MOUSE     Putative uncharacterized protein - Mus musculus (Mouse).
   TNR19_MOUSE      Tumor necrosis factor receptor superfamily member 19 - Mus m
   Q8BUM7_MOUSE     Putative uncharacterized protein - Mus musculus (Mouse).
   Q1KMU0_RAT       Tumor necrosis factor receptor superfamily member 19 - Rattu
   A1XGV6_CHICK     Troy-long - Gallus gallus (Chicken).
   A2SWM6_CHICK     Troy-short - Gallus gallus (Chicken).
   Q1ECV9_DANRE     Zgc:136805 - Danio rerio (Zebrafish) (Brachydanio rerio).
 
   B4E2I6_HUMAN     cDNA FLJ50364, highly similar to Tumor necrosis factor recep
   Q8BWR1_MOUSE     Putative uncharacterized protein - Mus musculus (Mouse).
   Q2HJB7_BOVIN     Tumor necrosis factor receptor superfamily, member 19 - Bos 

SCAN HISTORY SPTR57_40f 2 300 NSINGLE INITIAL MOTIF SETS TNFACTORR191 Length of motif = 21 Motif number = 1 Tumour necrosis factor receptor 19 motif I - 1 PCODE ST INT LSCKVTCESGDCRQQEFRDRS TNR19_HUMAN 23 23 LACKVSCETGDCRQQEFKDRS TNR19_MOUSE 23 23 TNFACTORR192 Length of motif = 24 Motif number = 2 Tumour necrosis factor receptor 19 motif II - 1 PCODE ST INT YEPHCASKVNLVKIASTASSPRDT TNR19_HUMAN 145 101 YEPHCTSKVNLVKISSTVSSPRDT TNR19_MOUSE 145 101 TNFACTORR193 Length of motif = 28 Motif number = 3 Tumour necrosis factor receptor 19 motif III - 1 PCODE ST INT FMEKKPSWSLRSQDIQYNGSELSCFDRP TNR19_HUMAN 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDQP TNR19_MOUSE 197 28 TNFACTORR194 Length of motif = 21 Motif number = 4 Tumour necrosis factor receptor 19 motif IV - 1 PCODE ST INT RDSVQTCGPVRLLPSMCCEEA TNR19_HUMAN 239 14 RDSAPMYGPVHLIPSLCCEEA TNR19_MOUSE 239 14 FINAL MOTIF SETS TNFACTORR191 Length of motif = 21 Motif number = 1 Tumour necrosis factor receptor 19 motif I - 2 PCODE ST INT LSCKVTCESGDCRQQEFRDRS A8KA26_HUMAN 23 23 LSCKVTCESGDCRQQEFRDRS TNR19_HUMAN 23 23 LSCKVTCESGDCRQQEFRDRS B1AM40_HUMAN 23 23 LSCKVTCESGDCRQQEFRDRS A8KA09_HUMAN 23 23 LACKVSCETGDCRQQEFKDRS Q80T13_MOUSE 23 23 LACKVSCETGDCRQQEFKDRS TNR19_MOUSE 23 23 LACKVSCETGDCRQQEFKDRS Q8BUM7_MOUSE 23 23 LSCKASCETGDCRQQEFKDRS Q1KMU0_RAT 23 23 LLSRVICETGDCREQEFRDHA A1XGV6_CHICK 22 22 LLSRVICETGDCREQEFRDHA A2SWM6_CHICK 22 22 LFAVMAEERRDCREQEYKDKF Q1ECV9_DANRE 23 23 TNFACTORR192 Length of motif = 24 Motif number = 2 Tumour necrosis factor receptor 19 motif II - 2 PCODE ST INT YEPHCASKVNLVKIASTASSPRDT A8KA26_HUMAN 145 101 YEPHCASKVNLVKIASTASSPRDT TNR19_HUMAN 145 101 YEPHCASKVNLVKIASTASSPRDT B1AM40_HUMAN 145 101 YEPHCASKVNLVKIVSTASSPRDT A8KA09_HUMAN 145 101 YEPHCTSKVNLVKISSTVSSPRDT Q80T13_MOUSE 145 101 YEPHCTSKVNLVKISSTVSSPRDT TNR19_MOUSE 145 101 YEPHCTSKVNLVKISSTVSSPRDT Q8BUM7_MOUSE 145 101 YEPHCTSKVNLVKISSTVSSPRDT Q1KMU0_RAT 145 101 YEPHCTTKVNLVKIPSTASSPRDT A1XGV6_CHICK 144 101 YEPHCTTKVNLVKIPSTASSPRDT A2SWM6_CHICK 144 101 YETHCMGRVNLVPLPSTVSSPRDM Q1ECV9_DANRE 145 101 TNFACTORR193 Length of motif = 28 Motif number = 3 Tumour necrosis factor receptor 19 motif III - 2 PCODE ST INT FMEKKPSWSLRSQDIQYNGSELSCFDRP A8KA26_HUMAN 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDRP TNR19_HUMAN 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDRP B1AM40_HUMAN 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDRP A8KA09_HUMAN 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDQP Q80T13_MOUSE 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDQP TNR19_MOUSE 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDQP Q8BUM7_MOUSE 197 28 FMEKKPSWSLRSQDIQYNGSELSCFDQP Q1KMU0_RAT 197 28 FMEKKPSWSLRSQDIHYSGSELSCFDRP A1XGV6_CHICK 196 28 FMEKKPSWSLRSQDIHYSGSELSCFDRP A2SWM6_CHICK 196 28 QLLEKKPVSMRAHEGPFLGSELSCLDRR Q1ECV9_DANRE 196 27 TNFACTORR194 Length of motif = 21 Motif number = 4 Tumour necrosis factor receptor 19 motif IV - 2 PCODE ST INT RDSVQTCGPVRLLPSMCCEEA A8KA26_HUMAN 239 14 RDSVQTCGPVRLLPSMCCEEA TNR19_HUMAN 239 14 RDSVQTCGPVRLLPSMCCEEA B1AM40_HUMAN 239 14 RDSVQTCGPVRLLPSMCCEEA A8KA09_HUMAN 239 14 RDSAPMYGPVHLIPSLCCEEA Q80T13_MOUSE 239 14 RDSAPMYGPVHLIPSLCCEEA TNR19_MOUSE 239 14 RDSAPMYGPVHLIPSLCCEEA Q8BUM7_MOUSE 239 14 RDSVQTYGPVHLIPPLCCEEA Q1KMU0_RAT 239 14 RSTSQTCGPVHLIPSLCCDET A1XGV6_CHICK 238 14 RSTSQTCGMLSLFRSHCKEQE A2SWM6_CHICK 238 14 HGSEQTCGGVQLVSSVCCEDV Q1ECV9_DANRE 237 13

User query: Display/Full Code "TNFACTORR19"