WORKLIST ENTRIES (1):

TNFACTORR14 View alignment      Tumour necrosis factor receptor 14 signature
 Type of fingerprint: COMPOUND with 4  elements
Links:
   PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3
   PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6
   PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9
   PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01962 TNFACTORR12
   PRINTS; PR01963 TNFACTORR13B; PR01964 TNFACTORR13C; PR01966 TNFACTORR16
   PRINTS; PR01967 TNFACTORR17; PR01968 TNFACTORR18; PR01969 TNFACTORR19
   PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25
   PRINTS; PR01973 TNFACTORR27
   PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B
   MIM; 602746

 Creation date 23-JUN-2009

   1. ARMITAGE, R.
   Tumor necrosis factor receptor superfamily members and their ligands.
   CURR.OPIN.IMMUNOL. 6 407-413 (1994).

   2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
   LOETSCHER, H. AND LESSLAUER, W.
   Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
   complex: implications for TNF receptor activation.
   CELL 73 431-445 (1993).
  
   3. WU, H.
   Assembly of post-receptor signaling complexes for the tumor necrosis factor
   receptor superfamily.
   ADV.PROTEIN CHEM. 68 225-279 (2004).

   4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
   The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
   CELL 104 487-501 (2001).

   5. GRAVESTEIN, L. AND BORST, J.
   Tumor necrosis factor receptor family members in the immune system.
   SEMIN.IMMUNOL. 10 423-434 (1998).

   6. LOENEN, W.
   D27 and (TNFR) relatives in the immune system: their role in health and
   disease.
   SEMIN.IMMUNOL. 10 417-422 (1998).

   7. MONTGOMERY, R., WARNER, M., LUM, B. AND SPEAR, P.
   Herpes simplex virus-1 entry into cells mediated by a novel member of the 
   TNF/NGF receptor family.
   CELL 87 427-436 (1996).

   The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
   than 20 type-I transmembrane proteins. Family members are defined based on
   similarity in their extracellular domain - a region that contains many
   cysteine residues arranged in a specific repetitive pattern [1]. The
   cysteines allow formation of an extended rod-like structure, responsible for
   ligand binding [2].
  
   Upon receptor activation, different intracellular signalling complexes are
   assembled for different members of the TNFR superfamily, depending on their
   intracellular domains and sequences [3]. Activation of TNFRs can therefore
   induce a range of disparate effects, including cell proliferation,
   differentiation, survival, or apoptotic cell death, depending upon the
   receptor involved [4,5].
  
   TNFRs are widely distributed and play important roles in many crucial
   biological processes, such as lymphoid and neuronal development, innate and
   adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
   manipulate their signalling have potential roles in the prevention and
   treatment of many diseases, such as viral infections, coronary heart
   disease, transplant rejection, and immune disease [6].
  
   TNF receptor 14 is also known as herpesvirus entry mediator (HVEM). It plays
   an important role in the entry of herpes simplex virus into cells, and hence
   pathogenesis of the virus [7].
  
   TNFACTORR14 is a 3-element fingerprint that provides a signature for tumour
   necrosis factor receptor 14. The fingerprint was derived from an initial
   alignment of 6 sequences: the motifs were drawn from conserved regions in
   the N-terminal half of the alignment, focusing on those sections that
   characterise TNF receptor 14 but distinguish it from other TNF receptor
   subtypes - all motifs lie in the extracellular N-terminal region. Two 
   iterations on SPTR57_40f were required to reach convergence, at which point
   a true set comprising 11 sequences was identified. Two partial matches were
   also found, B4DU65_HUMAN and B4E0P6_HUMAN, both which are translated human
   cDNA sequences that fail to match motif 4.

  SUMMARY INFORMATION
     11 codes involving  4 elements
      2 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    4|  11   11   11   11  
    3|   2    2    2    0  
    2|   0    0    0    0  
   --+---------------------
     |   1    2    3    4  

True positives..
 B9A034_HUMAN   TNR14_HUMAN    B9DI89_HUMAN   Q3SXX1_MOUSE   
 Q80WM9_MOUSE   Q71F55_MOUSE   Q0MSE4_MACMU   Q9XSZ8_CERAE   
 Q5BK53_RAT     B8LFF5_HORSE   Q4G265_HORSE   
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 B4DU65_HUMAN   B4E0P6_HUMAN   


  PROTEIN TITLES
   B9A034_HUMAN     Tumor necrosis factor receptor superfamily, member 14 (Herpe
   TNR14_HUMAN      Tumor necrosis factor receptor superfamily member 14 - Homo 
   B9DI89_HUMAN     Tumor necrosis factor receptor superfamily, member 14 (Herpe
   Q3SXX1_MOUSE     Tumor necrosis factor receptor superfamily, member 14 (Herpe
   Q80WM9_MOUSE     Tumor necrosis factor receptor superfamily member 14 - Mus m
   Q71F55_MOUSE     Herpes virus entry mediator - Mus musculus (Mouse).
   Q0MSE4_MACMU     Herpesvirus entry mediator - Macaca mulatta (Rhesus macaque)
   Q9XSZ8_CERAE     HveAs - Cercopithecus aethiops (Green monkey) (Grivet).
   Q5BK53_RAT       Tumor necrosis factor receptor superfamily, member 14 (Herpe
   B8LFF5_HORSE     ELR1-insert - Equus caballus (Horse).
   Q4G265_HORSE     ELR1 - Equus caballus (Horse).
 
   B4DU65_HUMAN     cDNA FLJ57170, highly similar to Tumor necrosis factor recep
   B4E0P6_HUMAN     cDNA FLJ56728, highly similar to Tumor necrosis factor recep

SCAN HISTORY SPTR57_40f 2 300 NSINGLE INITIAL MOTIF SETS TNFACTORR141 Length of motif = 15 Motif number = 1 Tumour necrosis factor receptor 14 motif I - 1 PCODE ST INT MEPPGDWGPPPWRST TNR14_HUMAN 1 1 MEPLPGWESSPWSRA Q5BK53_RAT 1 1 MEPPGGWGSPPRRPA Q9XSZ8_CERAE 1 1 MEPLPGWGSAPWSQA Q80WM9_MOUSE 1 1 MEPPGGWGSPPRRPA Q0MSE4_MACMU 1 1 MEPLRGWGPPPWSPA Q4G265_HORSE 1 1 TNFACTORR142 Length of motif = 15 Motif number = 2 Tumour necrosis factor receptor 14 motif II - 1 PCODE ST INT GYRVKEACGELTGTV TNR14_HUMAN 60 44 GYHVKQVCSEHTGTV Q5BK53_RAT 58 42 GFHVRQACGEQTGTV Q9XSZ8_CERAE 60 44 GYHVKQVCSEHTGTV Q80WM9_MOUSE 60 44 GFHVRQACGEQTGTV Q0MSE4_MACMU 60 44 GYRVKQACGELTGTV Q4G265_HORSE 60 44 TNFACTORR143 Length of motif = 15 Motif number = 3 Tumour necrosis factor receptor 14 motif III - 1 PCODE ST INT TYIAHLNGLSKCLQC TNR14_HUMAN 82 7 TYTAHANGLSKCLPC Q5BK53_RAT 80 7 TYIAHFNGLSKCLQC Q9XSZ8_CERAE 82 7 TYTAHANGLSKCLPC Q80WM9_MOUSE 82 7 TYIAHFNGLSKCLQC Q0MSE4_MACMU 82 7 TFSAHLNGLSKCLPC Q4G265_HORSE 82 7 TNFACTORR144 Length of motif = 13 Motif number = 4 Tumour necrosis factor receptor 14 motif IV - 1 PCODE ST INT FCIVQDGDHCAAC TNR14_HUMAN 126 29 FCENQDGGACSTC Q5BK53_RAT 124 29 FCIIQDGDHCAAC Q9XSZ8_CERAE 126 29 FCENQDGSHCSTC Q80WM9_MOUSE 126 29 FCIIQDGDHCAAC Q0MSE4_MACMU 126 29 FCVSEKGDDCVEC Q4G265_HORSE 126 29 FINAL MOTIF SETS TNFACTORR141 Length of motif = 15 Motif number = 1 Tumour necrosis factor receptor 14 motif I - 2 PCODE ST INT MEPPGDWGPPPWRST B9A034_HUMAN 1 1 MEPPGDWGPPPWRST TNR14_HUMAN 1 1 MEPPGDWGPPPWRST B9DI89_HUMAN 1 1 MEPLPGWGSAPWSQA Q3SXX1_MOUSE 1 1 MEPLPGWGSAPWSQA Q80WM9_MOUSE 1 1 MEPLPGWGSAPWSQA Q71F55_MOUSE 1 1 MEPPGGWGSPPRRPA Q0MSE4_MACMU 1 1 MEPPGGWGSPPRRPA Q9XSZ8_CERAE 1 1 MEPLPGWESSPWSRA Q5BK53_RAT 1 1 MEPLRGWGPPPWSPA B8LFF5_HORSE 1 1 MEPLRGWGPPPWSPA Q4G265_HORSE 1 1 TNFACTORR142 Length of motif = 15 Motif number = 2 Tumour necrosis factor receptor 14 motif II - 2 PCODE ST INT GYRVKEACGELTGTV B9A034_HUMAN 60 44 GYRVKEACGELTGTV TNR14_HUMAN 60 44 GYRVKEACGELTGTV B9DI89_HUMAN 60 44 GYHVKQVCSEHTGTV Q3SXX1_MOUSE 60 44 GYHVKQVCSEHTGTV Q80WM9_MOUSE 60 44 GYHVKQVCSEHTGTV Q71F55_MOUSE 60 44 GFHVRQACGEQTGTV Q0MSE4_MACMU 60 44 GFHVRQACGEQTGTV Q9XSZ8_CERAE 60 44 GYHVKQVCSEHTGTV Q5BK53_RAT 58 42 GYRVKQACGELTGTV B8LFF5_HORSE 60 44 GYRVKQACGELTGTV Q4G265_HORSE 60 44 TNFACTORR143 Length of motif = 15 Motif number = 3 Tumour necrosis factor receptor 14 motif III - 2 PCODE ST INT TYIAHLNGLSKCLQC B9A034_HUMAN 82 7 TYIAHLNGLSKCLQC TNR14_HUMAN 82 7 TYIAHLNGLSKCLQC B9DI89_HUMAN 82 7 TYTAHANGLSKCLPC Q3SXX1_MOUSE 82 7 TYTAHANGLSKCLPC Q80WM9_MOUSE 82 7 TYTAHANGLSKCLPC Q71F55_MOUSE 82 7 TYIAHFNGLSKCLQC Q0MSE4_MACMU 82 7 TYIAHFNGLSKCLQC Q9XSZ8_CERAE 82 7 TYTAHANGLSKCLPC Q5BK53_RAT 80 7 TFSAHLNGLSKCLPC B8LFF5_HORSE 82 7 TFSAHLNGLSKCLPC Q4G265_HORSE 82 7 TNFACTORR144 Length of motif = 13 Motif number = 4 Tumour necrosis factor receptor 14 motif IV - 2 PCODE ST INT FCIVQDGDHCAAC B9A034_HUMAN 126 29 FCIVQDGDHCAAC TNR14_HUMAN 126 29 FCIVQDGDHCAAC B9DI89_HUMAN 126 29 FCENQDGSHCSTC Q3SXX1_MOUSE 126 29 FCENQDGSHCSTC Q80WM9_MOUSE 126 29 FCENQDGSHCSTC Q71F55_MOUSE 126 29 FCIIQDGDHCAAC Q0MSE4_MACMU 126 29 FCIIQDGDHCAAC Q9XSZ8_CERAE 126 29 FCENQDGGACSTC Q5BK53_RAT 124 29 FCVSEKGDDCVEC B8LFF5_HORSE 126 29 FCVSEKGDDCVEC Q4G265_HORSE 126 29

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