WORKLIST ENTRIES (1):
TNFACTORR14 View alignment Tumour necrosis factor receptor 14 signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3
PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6
PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9
PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01962 TNFACTORR12
PRINTS; PR01963 TNFACTORR13B; PR01964 TNFACTORR13C; PR01966 TNFACTORR16
PRINTS; PR01967 TNFACTORR17; PR01968 TNFACTORR18; PR01969 TNFACTORR19
PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25
PRINTS; PR01973 TNFACTORR27
PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B
MIM; 602746
Creation date 23-JUN-2009
1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
7. MONTGOMERY, R., WARNER, M., LUM, B. AND SPEAR, P.
Herpes simplex virus-1 entry into cells mediated by a novel member of the
TNF/NGF receptor family.
CELL 87 427-436 (1996).
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
TNF receptor 14 is also known as herpesvirus entry mediator (HVEM). It plays
an important role in the entry of herpes simplex virus into cells, and hence
pathogenesis of the virus [7].
TNFACTORR14 is a 3-element fingerprint that provides a signature for tumour
necrosis factor receptor 14. The fingerprint was derived from an initial
alignment of 6 sequences: the motifs were drawn from conserved regions in
the N-terminal half of the alignment, focusing on those sections that
characterise TNF receptor 14 but distinguish it from other TNF receptor
subtypes - all motifs lie in the extracellular N-terminal region. Two
iterations on SPTR57_40f were required to reach convergence, at which point
a true set comprising 11 sequences was identified. Two partial matches were
also found, B4DU65_HUMAN and B4E0P6_HUMAN, both which are translated human
cDNA sequences that fail to match motif 4.
SUMMARY INFORMATION
11 codes involving 4 elements
2 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 11 11 11 11
3| 2 2 2 0
2| 0 0 0 0
--+---------------------
| 1 2 3 4
True positives..
B9A034_HUMAN TNR14_HUMAN B9DI89_HUMAN Q3SXX1_MOUSE
Q80WM9_MOUSE Q71F55_MOUSE Q0MSE4_MACMU Q9XSZ8_CERAE
Q5BK53_RAT B8LFF5_HORSE Q4G265_HORSE
Subfamily: Codes involving 3 elements
Subfamily True positives..
B4DU65_HUMAN B4E0P6_HUMAN
PROTEIN TITLES
B9A034_HUMAN Tumor necrosis factor receptor superfamily, member 14 (Herpe
TNR14_HUMAN Tumor necrosis factor receptor superfamily member 14 - Homo
B9DI89_HUMAN Tumor necrosis factor receptor superfamily, member 14 (Herpe
Q3SXX1_MOUSE Tumor necrosis factor receptor superfamily, member 14 (Herpe
Q80WM9_MOUSE Tumor necrosis factor receptor superfamily member 14 - Mus m
Q71F55_MOUSE Herpes virus entry mediator - Mus musculus (Mouse).
Q0MSE4_MACMU Herpesvirus entry mediator - Macaca mulatta (Rhesus macaque)
Q9XSZ8_CERAE HveAs - Cercopithecus aethiops (Green monkey) (Grivet).
Q5BK53_RAT Tumor necrosis factor receptor superfamily, member 14 (Herpe
B8LFF5_HORSE ELR1-insert - Equus caballus (Horse).
Q4G265_HORSE ELR1 - Equus caballus (Horse).
B4DU65_HUMAN cDNA FLJ57170, highly similar to Tumor necrosis factor recep
B4E0P6_HUMAN cDNA FLJ56728, highly similar to Tumor necrosis factor recep
SCAN HISTORY
SPTR57_40f 2 300 NSINGLE
INITIAL MOTIF SETS
TNFACTORR141 Length of motif = 15 Motif number = 1
Tumour necrosis factor receptor 14 motif I - 1
PCODE ST INT
MEPPGDWGPPPWRST TNR14_HUMAN 1 1
MEPLPGWESSPWSRA Q5BK53_RAT 1 1
MEPPGGWGSPPRRPA Q9XSZ8_CERAE 1 1
MEPLPGWGSAPWSQA Q80WM9_MOUSE 1 1
MEPPGGWGSPPRRPA Q0MSE4_MACMU 1 1
MEPLRGWGPPPWSPA Q4G265_HORSE 1 1
TNFACTORR142 Length of motif = 15 Motif number = 2
Tumour necrosis factor receptor 14 motif II - 1
PCODE ST INT
GYRVKEACGELTGTV TNR14_HUMAN 60 44
GYHVKQVCSEHTGTV Q5BK53_RAT 58 42
GFHVRQACGEQTGTV Q9XSZ8_CERAE 60 44
GYHVKQVCSEHTGTV Q80WM9_MOUSE 60 44
GFHVRQACGEQTGTV Q0MSE4_MACMU 60 44
GYRVKQACGELTGTV Q4G265_HORSE 60 44
TNFACTORR143 Length of motif = 15 Motif number = 3
Tumour necrosis factor receptor 14 motif III - 1
PCODE ST INT
TYIAHLNGLSKCLQC TNR14_HUMAN 82 7
TYTAHANGLSKCLPC Q5BK53_RAT 80 7
TYIAHFNGLSKCLQC Q9XSZ8_CERAE 82 7
TYTAHANGLSKCLPC Q80WM9_MOUSE 82 7
TYIAHFNGLSKCLQC Q0MSE4_MACMU 82 7
TFSAHLNGLSKCLPC Q4G265_HORSE 82 7
TNFACTORR144 Length of motif = 13 Motif number = 4
Tumour necrosis factor receptor 14 motif IV - 1
PCODE ST INT
FCIVQDGDHCAAC TNR14_HUMAN 126 29
FCENQDGGACSTC Q5BK53_RAT 124 29
FCIIQDGDHCAAC Q9XSZ8_CERAE 126 29
FCENQDGSHCSTC Q80WM9_MOUSE 126 29
FCIIQDGDHCAAC Q0MSE4_MACMU 126 29
FCVSEKGDDCVEC Q4G265_HORSE 126 29
FINAL MOTIF SETS
TNFACTORR141 Length of motif = 15 Motif number = 1
Tumour necrosis factor receptor 14 motif I - 2
PCODE ST INT
MEPPGDWGPPPWRST B9A034_HUMAN 1 1
MEPPGDWGPPPWRST TNR14_HUMAN 1 1
MEPPGDWGPPPWRST B9DI89_HUMAN 1 1
MEPLPGWGSAPWSQA Q3SXX1_MOUSE 1 1
MEPLPGWGSAPWSQA Q80WM9_MOUSE 1 1
MEPLPGWGSAPWSQA Q71F55_MOUSE 1 1
MEPPGGWGSPPRRPA Q0MSE4_MACMU 1 1
MEPPGGWGSPPRRPA Q9XSZ8_CERAE 1 1
MEPLPGWESSPWSRA Q5BK53_RAT 1 1
MEPLRGWGPPPWSPA B8LFF5_HORSE 1 1
MEPLRGWGPPPWSPA Q4G265_HORSE 1 1
TNFACTORR142 Length of motif = 15 Motif number = 2
Tumour necrosis factor receptor 14 motif II - 2
PCODE ST INT
GYRVKEACGELTGTV B9A034_HUMAN 60 44
GYRVKEACGELTGTV TNR14_HUMAN 60 44
GYRVKEACGELTGTV B9DI89_HUMAN 60 44
GYHVKQVCSEHTGTV Q3SXX1_MOUSE 60 44
GYHVKQVCSEHTGTV Q80WM9_MOUSE 60 44
GYHVKQVCSEHTGTV Q71F55_MOUSE 60 44
GFHVRQACGEQTGTV Q0MSE4_MACMU 60 44
GFHVRQACGEQTGTV Q9XSZ8_CERAE 60 44
GYHVKQVCSEHTGTV Q5BK53_RAT 58 42
GYRVKQACGELTGTV B8LFF5_HORSE 60 44
GYRVKQACGELTGTV Q4G265_HORSE 60 44
TNFACTORR143 Length of motif = 15 Motif number = 3
Tumour necrosis factor receptor 14 motif III - 2
PCODE ST INT
TYIAHLNGLSKCLQC B9A034_HUMAN 82 7
TYIAHLNGLSKCLQC TNR14_HUMAN 82 7
TYIAHLNGLSKCLQC B9DI89_HUMAN 82 7
TYTAHANGLSKCLPC Q3SXX1_MOUSE 82 7
TYTAHANGLSKCLPC Q80WM9_MOUSE 82 7
TYTAHANGLSKCLPC Q71F55_MOUSE 82 7
TYIAHFNGLSKCLQC Q0MSE4_MACMU 82 7
TYIAHFNGLSKCLQC Q9XSZ8_CERAE 82 7
TYTAHANGLSKCLPC Q5BK53_RAT 80 7
TFSAHLNGLSKCLPC B8LFF5_HORSE 82 7
TFSAHLNGLSKCLPC Q4G265_HORSE 82 7
TNFACTORR144 Length of motif = 13 Motif number = 4
Tumour necrosis factor receptor 14 motif IV - 2
PCODE ST INT
FCIVQDGDHCAAC B9A034_HUMAN 126 29
FCIVQDGDHCAAC TNR14_HUMAN 126 29
FCIVQDGDHCAAC B9DI89_HUMAN 126 29
FCENQDGSHCSTC Q3SXX1_MOUSE 126 29
FCENQDGSHCSTC Q80WM9_MOUSE 126 29
FCENQDGSHCSTC Q71F55_MOUSE 126 29
FCIIQDGDHCAAC Q0MSE4_MACMU 126 29
FCIIQDGDHCAAC Q9XSZ8_CERAE 126 29
FCENQDGGACSTC Q5BK53_RAT 124 29
FCVSEKGDDCVEC B8LFF5_HORSE 126 29
FCVSEKGDDCVEC Q4G265_HORSE 126 29
User query: Display/Full Code "TNFACTORR14"