WORKLIST ENTRIES (1):
TNFACTORR12 View alignment Tumour necrosis factor receptor 12 signature
Type of fingerprint: COMPOUND with 3 elements
Links:
PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3
PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6
PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9
PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01963 TNFACTORR13B
PRINTS; PR01964 TNFACTORR13C; PR01965 TNFACTORR14; PR01966 TNFACTORR16
PRINTS; PR01967 TNFACTORR17; PR01968 TNFACTORR18; PR01969 TNFACTORR19
PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25
PRINTS; PR01973 TNFACTORR27
PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B
MIM; 605914
Creation date 23-JUN-2009
1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
7. WILEY, S., CASSIANO, L., LOFTON, T., DAVIS-SMITH, T., WINKLES, J.,
LINDNER, V., LIU, H., DANIEL, T., SMITH, C. AND FANSLOW, W.
A novel TNF receptor family member binds TWEAK and is implicated in
angiogenesis.
IMMUNITY 15 837-846 (2001).
8. MEIGHAN-MANTHA, R., HSU, D., GUO, Y., BROWN, S., FENG, S., PEIFLEY, K.,
ALBERTS, G., COPELAND, N., GILBERT, D., JENKINS, N., RICHARDS, C. AND
WINKLES, J.
The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that
modulates fibroblast adhesion and migration.
J.BIOL.CHEM. 274 33166-33176 (1999).
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
TNF receptor 12 (also known as TWEAK receptor, and fibroblast growth
factor-inducible-14 (Fn14)) has been implicated in endothelial cell growth
and migration [7]. The receptor may also play a role in cell-matrix
interactions [8].
TNFACTORR12 is a 3-element fingerprint that provides a signature for tumour
necrosis factor receptor 12. The fingerprint was derived from an initial
alignment of 3 sequences: the motifs were drawn from conserved regions
spanning virtually the full alignment length, focusing on those sections
that characterise TNF receptor 12 but distinguish it from other TNF receptor
subtypes - motifs 1 and 2 lie within the extracellular N-terminal region,
and motif 3 resides within the intracellular C-terminal region. Two
iterations on SPTR57_40f were required to reach convergence, at which point
a true set comprising 6 sequences was identified.
SUMMARY INFORMATION
6 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
3| 6 6 6
2| 0 0 0
--+----------------
| 1 2 3
True positives..
B7SLY2_PIG TNR12_MOUSE TNR12_HUMAN Q80XX9_RAT
B7ZQA3_XENLA Q6SIX7_XENLA
PROTEIN TITLES
B7SLY2_PIG Fibroblast growth factor-inducible 14 - Sus scrofa (Pig).
TNR12_MOUSE Tumor necrosis factor receptor superfamily member 12A - Mus
TNR12_HUMAN Tumor necrosis factor receptor superfamily member 12A - Homo
Q80XX9_RAT Type 1 transmembrane protein FN14 (Tumor necrosis factor rec
B7ZQA3_XENLA Fn14 protein - Xenopus laevis (African clawed frog).
Q6SIX7_XENLA Fn14 - Xenopus laevis (African clawed frog).
SCAN HISTORY
SPTR57_40f 2 300 NSINGLE
INITIAL MOTIF SETS
TNFACTORR121 Length of motif = 16 Motif number = 1
Tumour necrosis factor receptor 12 motif I - 1
PCODE ST INT
CSSGSSWSADLDKCMD TNR12_MOUSE 36 36
CSRGSSWSADLDKCMD TNR12_HUMAN 36 36
CPEGRAYSQDLGKCME Q6SIX7_XENLA 27 27
TNFACTORR122 Length of motif = 11 Motif number = 2
Tumour necrosis factor receptor 12 motif II - 1
PCODE ST INT
ARPHSDFCLGC TNR12_MOUSE 57 5
ARPHSDFCLGC TNR12_HUMAN 57 5
NSEKSDFCQNC Q6SIX7_XENLA 48 5
TNFACTORR123 Length of motif = 12 Motif number = 3
Tumour necrosis factor receptor 12 motif III - 1
PCODE ST INT
RREKFTTPIEET TNR12_MOUSE 106 38
RREKFTTPIEET TNR12_HUMAN 106 38
RKSKFTTPIEET Q6SIX7_XENLA 98 39
FINAL MOTIF SETS
TNFACTORR121 Length of motif = 16 Motif number = 1
Tumour necrosis factor receptor 12 motif I - 2
PCODE ST INT
CSRGSSWSADLDKCMD B7SLY2_PIG 36 36
CSSGSSWSADLDKCMD TNR12_MOUSE 36 36
CSRGSSWSADLDKCMD TNR12_HUMAN 36 36
CSSGSSWSADLDKCMD Q80XX9_RAT 36 36
CPEGRAYSQDLGKCME B7ZQA3_XENLA 27 27
CPEGRAYSQDLGKCME Q6SIX7_XENLA 27 27
TNFACTORR122 Length of motif = 11 Motif number = 2
Tumour necrosis factor receptor 12 motif II - 2
PCODE ST INT
ARPHSDFCLGC B7SLY2_PIG 57 5
ARPHSDFCLGC TNR12_MOUSE 57 5
ARPHSDFCLGC TNR12_HUMAN 57 5
ARPHSDFCLGC Q80XX9_RAT 57 5
NSEKSDFCQNC B7ZQA3_XENLA 48 5
NSEKSDFCQNC Q6SIX7_XENLA 48 5
TNFACTORR123 Length of motif = 12 Motif number = 3
Tumour necrosis factor receptor 12 motif III - 2
PCODE ST INT
RREKFTTPIEET B7SLY2_PIG 106 38
RREKFTTPIEET TNR12_MOUSE 106 38
RREKFTTPIEET TNR12_HUMAN 106 38
RREKFTTPIEET Q80XX9_RAT 106 38
RKSKFTTPIEET B7ZQA3_XENLA 98 39
RKSKFTTPIEET Q6SIX7_XENLA 98 39
User query: Display/Full Code "TNFACTORR12"