WORKLIST ENTRIES (1): TNFACTORR12 View alignment Tumour necrosis factor receptor 12 signature Type of fingerprint: COMPOUND with 3 elements Links: PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3 PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6 PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9 PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01963 TNFACTORR13B PRINTS; PR01964 TNFACTORR13C; PR01965 TNFACTORR14; PR01966 TNFACTORR16 PRINTS; PR01967 TNFACTORR17; PR01968 TNFACTORR18; PR01969 TNFACTORR19 PRINTS; PR01970 TNFACTORR19l; PR01971 TNFACTORR21; PR01972 TNFACTORR25 PRINTS; PR01973 TNFACTORR27 PRINTS; PR01974 TNFACTORR11A; PR01975 TNFACTORR11B MIM; 605914 Creation date 23-JUN-2009 1. ARMITAGE, R. Tumor necrosis factor receptor superfamily members and their ligands. CURR.OPIN.IMMUNOL. 6 407-413 (1994). 2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C., LOETSCHER, H. AND LESSLAUER, W. Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta complex: implications for TNF receptor activation. CELL 73 431-445 (1993). 3. WU, H. Assembly of post-receptor signaling complexes for the tumor necrosis factor receptor superfamily. ADV.PROTEIN CHEM. 68 225-279 (2004). 4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M. The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology. CELL 104 487-501 (2001). 5. GRAVESTEIN, L. AND BORST, J. Tumor necrosis factor receptor family members in the immune system. SEMIN.IMMUNOL. 10 423-434 (1998). 6. LOENEN, W. D27 and (TNFR) relatives in the immune system: their role in health and disease. SEMIN.IMMUNOL. 10 417-422 (1998). 7. WILEY, S., CASSIANO, L., LOFTON, T., DAVIS-SMITH, T., WINKLES, J., LINDNER, V., LIU, H., DANIEL, T., SMITH, C. AND FANSLOW, W. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. IMMUNITY 15 837-846 (2001). 8. MEIGHAN-MANTHA, R., HSU, D., GUO, Y., BROWN, S., FENG, S., PEIFLEY, K., ALBERTS, G., COPELAND, N., GILBERT, D., JENKINS, N., RICHARDS, C. AND WINKLES, J. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J.BIOL.CHEM. 274 33166-33176 (1999). The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern . The cysteines allow formation of an extended rod-like structure, responsible for ligand binding . Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences . Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [4,5]. TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis . Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease . TNF receptor 12 (also known as TWEAK receptor, and fibroblast growth factor-inducible-14 (Fn14)) has been implicated in endothelial cell growth and migration . The receptor may also play a role in cell-matrix interactions . TNFACTORR12 is a 3-element fingerprint that provides a signature for tumour necrosis factor receptor 12. The fingerprint was derived from an initial alignment of 3 sequences: the motifs were drawn from conserved regions spanning virtually the full alignment length, focusing on those sections that characterise TNF receptor 12 but distinguish it from other TNF receptor subtypes - motifs 1 and 2 lie within the extracellular N-terminal region, and motif 3 resides within the intracellular C-terminal region. Two iterations on SPTR57_40f were required to reach convergence, at which point a true set comprising 6 sequences was identified. SUMMARY INFORMATION 6 codes involving 3 elements 0 codes involving 2 elements COMPOSITE FINGERPRINT INDEX 3| 6 6 6 2| 0 0 0 --+---------------- | 1 2 3 True positives.. B7SLY2_PIG TNR12_MOUSE TNR12_HUMAN Q80XX9_RAT B7ZQA3_XENLA Q6SIX7_XENLA PROTEIN TITLES B7SLY2_PIG Fibroblast growth factor-inducible 14 - Sus scrofa (Pig). TNR12_MOUSE Tumor necrosis factor receptor superfamily member 12A - Mus TNR12_HUMAN Tumor necrosis factor receptor superfamily member 12A - Homo Q80XX9_RAT Type 1 transmembrane protein FN14 (Tumor necrosis factor rec B7ZQA3_XENLA Fn14 protein - Xenopus laevis (African clawed frog). Q6SIX7_XENLA Fn14 - Xenopus laevis (African clawed frog).
SCAN HISTORY SPTR57_40f 2 300 NSINGLE INITIAL MOTIF SETS TNFACTORR121 Length of motif = 16 Motif number = 1 Tumour necrosis factor receptor 12 motif I - 1 PCODE ST INT CSSGSSWSADLDKCMD TNR12_MOUSE 36 36 CSRGSSWSADLDKCMD TNR12_HUMAN 36 36 CPEGRAYSQDLGKCME Q6SIX7_XENLA 27 27 TNFACTORR122 Length of motif = 11 Motif number = 2 Tumour necrosis factor receptor 12 motif II - 1 PCODE ST INT ARPHSDFCLGC TNR12_MOUSE 57 5 ARPHSDFCLGC TNR12_HUMAN 57 5 NSEKSDFCQNC Q6SIX7_XENLA 48 5 TNFACTORR123 Length of motif = 12 Motif number = 3 Tumour necrosis factor receptor 12 motif III - 1 PCODE ST INT RREKFTTPIEET TNR12_MOUSE 106 38 RREKFTTPIEET TNR12_HUMAN 106 38 RKSKFTTPIEET Q6SIX7_XENLA 98 39 FINAL MOTIF SETS TNFACTORR121 Length of motif = 16 Motif number = 1 Tumour necrosis factor receptor 12 motif I - 2 PCODE ST INT CSRGSSWSADLDKCMD B7SLY2_PIG 36 36 CSSGSSWSADLDKCMD TNR12_MOUSE 36 36 CSRGSSWSADLDKCMD TNR12_HUMAN 36 36 CSSGSSWSADLDKCMD Q80XX9_RAT 36 36 CPEGRAYSQDLGKCME B7ZQA3_XENLA 27 27 CPEGRAYSQDLGKCME Q6SIX7_XENLA 27 27 TNFACTORR122 Length of motif = 11 Motif number = 2 Tumour necrosis factor receptor 12 motif II - 2 PCODE ST INT ARPHSDFCLGC B7SLY2_PIG 57 5 ARPHSDFCLGC TNR12_MOUSE 57 5 ARPHSDFCLGC TNR12_HUMAN 57 5 ARPHSDFCLGC Q80XX9_RAT 57 5 NSEKSDFCQNC B7ZQA3_XENLA 48 5 NSEKSDFCQNC Q6SIX7_XENLA 48 5 TNFACTORR123 Length of motif = 12 Motif number = 3 Tumour necrosis factor receptor 12 motif III - 2 PCODE ST INT RREKFTTPIEET B7SLY2_PIG 106 38 RREKFTTPIEET TNR12_MOUSE 106 38 RREKFTTPIEET TNR12_HUMAN 106 38 RREKFTTPIEET Q80XX9_RAT 106 38 RKSKFTTPIEET B7ZQA3_XENLA 98 39 RKSKFTTPIEET Q6SIX7_XENLA 98 39
User query: Display/Full Code "TNFACTORR12"