WORKLIST ENTRIES (1):

TNFACTORR11A View alignment     Tumour necrosis factor receptor 11A signature
 Type of fingerprint: COMPOUND with 5  elements
Links:
   PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3
   PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6
   PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9
   PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01962 TNFACTORR12
   PRINTS; PR01963 TNFACTORR13B; PR01964 TNFACTORR13C; PR01965 TNFACTORR14
   PRINTS; PR01966 TNFACTORR16; PR01967 TNFACTORR17; PR01968 TNFACTORR18
   PRINTS; PR01969 TNFACTORR19; PR01970 TNFACTORR19L; PR01971 TNFACTORR21
   PRINTS; PR01972 TNFACTORR25; PR01973 TNFACTORR27
   PRINTS; PR01975 TNFACTORR11B
   MIM; 603499

 Creation date 23-JUN-2009

   1. ARMITAGE, R.
   Tumor necrosis factor receptor superfamily members and their ligands.
   CURR.OPIN.IMMUNOL. 6 407-413 (1994).

   2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
   LOETSCHER, H. AND LESSLAUER, W.
   Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
   complex: implications for TNF receptor activation.
   CELL 73 431-445 (1993).
  
   3. WU, H.
   Assembly of post-receptor signaling complexes for the tumor necrosis factor
   receptor superfamily.
   ADV.PROTEIN CHEM. 68 225-279 (2004).

   4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
   The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
   CELL 104 487-501 (2001).

   5. GRAVESTEIN, L. AND BORST, J.
   Tumor necrosis factor receptor family members in the immune system.
   SEMIN.IMMUNOL. 10 423-434 (1998).

   6. LOENEN, W.
   D27 and (TNFR) relatives in the immune system: their role in health and
   disease.
   SEMIN.IMMUNOL. 10 417-422 (1998).

   7. NAKAGAWA, N., KINOSAKI, M., YAMAGUCHI, K., SHIMA, N., YASUDA, H.,
   YANO, K., MORINAGA, T. AND HIGASHIO, K.
   RANK is the essential signaling receptor for osteoclast differentiation 
   factor in osteoclastogenesis.
   BIOCHEM.BIOPHYS.RES.COMMUN. 253 395-400 (1998).

   8. HOFBAUER, L. AND HEUFELDER, A.
   Role of receptor activator of nuclear factor-kappaB ligand and 
   osteoprotegerin in bone cell biology.
   J.MOL.MED. 79 243-253 (2001).

   9. ZHANG, S., LIU, C., HUANG, P., ZHOU, S., REN, J., KITAMURA, Y., TANG, P.,
   BI, Z. AND GAO, B.
   The affinity of human RANK binding to its ligand RANKL.
   ARCH.BIOCHEM.BIOPHYS. 487 49-53 (2009).

   The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
   than 20 type-I transmembrane proteins. Family members are defined based on
   similarity in their extracellular domain - a region that contains many
   cysteine residues arranged in a specific repetitive pattern [1]. The
   cysteines allow formation of an extended rod-like structure, responsible for
   ligand binding [2].
  
   Upon receptor activation, different intracellular signalling complexes are
   assembled for different members of the TNFR superfamily, depending on their
   intracellular domains and sequences [3]. Activation of TNFRs can therefore
   induce a range of disparate effects, including cell proliferation,
   differentiation, survival, or apoptotic cell death, depending upon the
   receptor involved [4,5].
  
   TNFRs are widely distributed and play important roles in many crucial
   biological processes, such as lymphoid and neuronal development, innate and
   adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
   manipulate their signalling have potential roles in the prevention and
   treatment of many diseases, such as viral infections, coronary heart
   disease, transplant rejection, and immune disease [6].
  
   TNF receptors 11A and 11B mediate the effects of receptor activator for
   NF-kappa-B ligand (RANKL), an essential osteoclast regulatory factor. The
   receptors have opposing effects - activation of TNF receptor 11A by RANKL
   promotes osteoclast differentiation [7], while TNF receptor 11B acts as a
   soluble decoy receptor for the ligand, thus inhibiting differentiation [8].
  
   Mutations in the TNF receptor 11A gene have been implicated in a range of 
   bone disorders, such as expansile osteolysis, osteopetrosis, and Paget 
   disease of bone. The receptor also has a role in immune function, vascular 
   disease and mammary gland development [9].
  
   TNFACTORR11A is a 5-element fingerprint that provides a signature for
   tumour necrosis factor receptor 11A. The fingerprint was derived from an 
   initial alignment of 2 sequences: the motifs were drawn from conserved 
   regions spanning virtually the full alignment length, focusing on those 
   sections that characterise TNF receptor 11A but distinguish it from other 
   TNF receptor subtypes - motif 1 resides within the extracellular N-terminal
   region; motif 2 lies partially within the extracellular N-terminal region
   and partially within the transmembrane domain; and motifs 3 and 4 reside
   within the intracellular C-terminal region. A single iteration on SPTR57_40f
   was required to reach convergence, no further sequences being identified 
   beyond the starting set.

  SUMMARY INFORMATION
      2 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    5|   2    2    2    2    2  
    4|   0    0    0    0    0  
    3|   0    0    0    0    0  
    2|   0    0    0    0    0  
   --+--------------------------
     |   1    2    3    4    5  

True positives..
 TNR11_HUMAN    TNR11_MOUSE    


  PROTEIN TITLES
   TNR11_HUMAN      Tumor necrosis factor receptor superfamily member 11A - Homo
   TNR11_MOUSE      Tumor necrosis factor receptor superfamily member 11A - Mus 

SCAN HISTORY SPTR57_40f 1 300 NSINGLE INITIAL MOTIF SETS TNFACTORR11A1 Length of motif = 24 Motif number = 1 Tumour necrosis factor receptor 11A motif I - 1 PCODE ST INT PLQVTLQVTPPCTQERHYEHLGRC TNR11_MOUSE 24 24 RLQVALQIAPPCTSEKHYEHLGRC TNR11_HUMAN 23 23 TNFACTORR11A2 Length of motif = 12 Motif number = 2 Tumour necrosis factor receptor 11A motif II - 1 PCODE ST INT PKEAQAYLPSLI TNR11_MOUSE 205 157 PNEPHVYLPGLI TNR11_HUMAN 204 157 TNFACTORR11A3 Length of motif = 26 Motif number = 3 Tumour necrosis factor receptor 11A motif III - 1 PCODE ST INT TANLWNWVNDACSSLSGNKESSGDRC TNR11_MOUSE 244 27 TANLWHWINEACGRLSGDKESSGDSC TNR11_HUMAN 243 27 TNFACTORR11A4 Length of motif = 22 Motif number = 4 Tumour necrosis factor receptor 11A motif IV - 1 PCODE ST INT EYTDRPSQPSTGSLLLIQQGSK TNR11_MOUSE 344 74 EYMDRPSQPTDQLLFLTEPGSK TNR11_HUMAN 348 79 TNFACTORR11A5 Length of motif = 16 Motif number = 5 Tumour necrosis factor receptor 11A motif V - 1 PCODE ST INT ETLAHRDSFAGTAPRF TNR11_MOUSE 564 198 ETLARRDSFAGNGPRF TNR11_HUMAN 573 203 FINAL MOTIF SETS TNFACTORR11A1 Length of motif = 24 Motif number = 1 Tumour necrosis factor receptor 11A motif I - 1 PCODE ST INT RLQVALQIAPPCTSEKHYEHLGRC TNR11_HUMAN 23 23 PLQVTLQVTPPCTQERHYEHLGRC TNR11_MOUSE 24 24 TNFACTORR11A2 Length of motif = 12 Motif number = 2 Tumour necrosis factor receptor 11A motif II - 1 PCODE ST INT PNEPHVYLPGLI TNR11_HUMAN 204 157 PKEAQAYLPSLI TNR11_MOUSE 205 157 TNFACTORR11A3 Length of motif = 26 Motif number = 3 Tumour necrosis factor receptor 11A motif III - 1 PCODE ST INT TANLWHWINEACGRLSGDKESSGDSC TNR11_HUMAN 243 27 TANLWNWVNDACSSLSGNKESSGDRC TNR11_MOUSE 244 27 TNFACTORR11A4 Length of motif = 22 Motif number = 4 Tumour necrosis factor receptor 11A motif IV - 1 PCODE ST INT EYMDRPSQPTDQLLFLTEPGSK TNR11_HUMAN 348 79 EYTDRPSQPSTGSLLLIQQGSK TNR11_MOUSE 344 74 TNFACTORR11A5 Length of motif = 16 Motif number = 5 Tumour necrosis factor receptor 11A motif V - 1 PCODE ST INT ETLARRDSFAGNGPRF TNR11_HUMAN 573 203 ETLAHRDSFAGTAPRF TNR11_MOUSE 564 198

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