WORKLIST ENTRIES (1):
TNFACTORR11A View alignment Tumour necrosis factor receptor 11A signature
Type of fingerprint: COMPOUND with 5 elements
Links:
PRINTS; PR01918 TNFACTORR1A; PR01919 TNFACTORR1B; PR01920 TNFACTORR3
PRINTS; PR01921 TNFACTORR4; PR01922 TNFACTORR5; PR01680 TNFACTORR6
PRINTS; PR01960 TNFACTORR7; PR01923 TNFACTORR8; PR01924 TNFACTORR9
PRINTS; PR01956 TNFACTORR10; PR01961 TNFACTORR11; PR01962 TNFACTORR12
PRINTS; PR01963 TNFACTORR13B; PR01964 TNFACTORR13C; PR01965 TNFACTORR14
PRINTS; PR01966 TNFACTORR16; PR01967 TNFACTORR17; PR01968 TNFACTORR18
PRINTS; PR01969 TNFACTORR19; PR01970 TNFACTORR19L; PR01971 TNFACTORR21
PRINTS; PR01972 TNFACTORR25; PR01973 TNFACTORR27
PRINTS; PR01975 TNFACTORR11B
MIM; 603499
Creation date 23-JUN-2009
1. ARMITAGE, R.
Tumor necrosis factor receptor superfamily members and their ligands.
CURR.OPIN.IMMUNOL. 6 407-413 (1994).
2. BANNER D., D'ARCY, A., JAMES, W., GENTZ, R., SCHOENFELD, H., BROGER, C.,
LOETSCHER, H. AND LESSLAUER, W.
Crystal structure of the soluble human 55 kD TNF receptor-human TNF-beta
complex: implications for TNF receptor activation.
CELL 73 431-445 (1993).
3. WU, H.
Assembly of post-receptor signaling complexes for the tumor necrosis factor
receptor superfamily.
ADV.PROTEIN CHEM. 68 225-279 (2004).
4. LOCKSLEY, R., KILLEEN, N. AND LENARDO, M.
The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology.
CELL 104 487-501 (2001).
5. GRAVESTEIN, L. AND BORST, J.
Tumor necrosis factor receptor family members in the immune system.
SEMIN.IMMUNOL. 10 423-434 (1998).
6. LOENEN, W.
D27 and (TNFR) relatives in the immune system: their role in health and
disease.
SEMIN.IMMUNOL. 10 417-422 (1998).
7. NAKAGAWA, N., KINOSAKI, M., YAMAGUCHI, K., SHIMA, N., YASUDA, H.,
YANO, K., MORINAGA, T. AND HIGASHIO, K.
RANK is the essential signaling receptor for osteoclast differentiation
factor in osteoclastogenesis.
BIOCHEM.BIOPHYS.RES.COMMUN. 253 395-400 (1998).
8. HOFBAUER, L. AND HEUFELDER, A.
Role of receptor activator of nuclear factor-kappaB ligand and
osteoprotegerin in bone cell biology.
J.MOL.MED. 79 243-253 (2001).
9. ZHANG, S., LIU, C., HUANG, P., ZHOU, S., REN, J., KITAMURA, Y., TANG, P.,
BI, Z. AND GAO, B.
The affinity of human RANK binding to its ligand RANKL.
ARCH.BIOCHEM.BIOPHYS. 487 49-53 (2009).
The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more
than 20 type-I transmembrane proteins. Family members are defined based on
similarity in their extracellular domain - a region that contains many
cysteine residues arranged in a specific repetitive pattern [1]. The
cysteines allow formation of an extended rod-like structure, responsible for
ligand binding [2].
Upon receptor activation, different intracellular signalling complexes are
assembled for different members of the TNFR superfamily, depending on their
intracellular domains and sequences [3]. Activation of TNFRs can therefore
induce a range of disparate effects, including cell proliferation,
differentiation, survival, or apoptotic cell death, depending upon the
receptor involved [4,5].
TNFRs are widely distributed and play important roles in many crucial
biological processes, such as lymphoid and neuronal development, innate and
adaptive immunity, and maintenance of cellular homeostasis [3]. Drugs that
manipulate their signalling have potential roles in the prevention and
treatment of many diseases, such as viral infections, coronary heart
disease, transplant rejection, and immune disease [6].
TNF receptors 11A and 11B mediate the effects of receptor activator for
NF-kappa-B ligand (RANKL), an essential osteoclast regulatory factor. The
receptors have opposing effects - activation of TNF receptor 11A by RANKL
promotes osteoclast differentiation [7], while TNF receptor 11B acts as a
soluble decoy receptor for the ligand, thus inhibiting differentiation [8].
Mutations in the TNF receptor 11A gene have been implicated in a range of
bone disorders, such as expansile osteolysis, osteopetrosis, and Paget
disease of bone. The receptor also has a role in immune function, vascular
disease and mammary gland development [9].
TNFACTORR11A is a 5-element fingerprint that provides a signature for
tumour necrosis factor receptor 11A. The fingerprint was derived from an
initial alignment of 2 sequences: the motifs were drawn from conserved
regions spanning virtually the full alignment length, focusing on those
sections that characterise TNF receptor 11A but distinguish it from other
TNF receptor subtypes - motif 1 resides within the extracellular N-terminal
region; motif 2 lies partially within the extracellular N-terminal region
and partially within the transmembrane domain; and motifs 3 and 4 reside
within the intracellular C-terminal region. A single iteration on SPTR57_40f
was required to reach convergence, no further sequences being identified
beyond the starting set.
SUMMARY INFORMATION
2 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
5| 2 2 2 2 2
4| 0 0 0 0 0
3| 0 0 0 0 0
2| 0 0 0 0 0
--+--------------------------
| 1 2 3 4 5
True positives..
TNR11_HUMAN TNR11_MOUSE
PROTEIN TITLES
TNR11_HUMAN Tumor necrosis factor receptor superfamily member 11A - Homo
TNR11_MOUSE Tumor necrosis factor receptor superfamily member 11A - Mus
SCAN HISTORY
SPTR57_40f 1 300 NSINGLE
INITIAL MOTIF SETS
TNFACTORR11A1 Length of motif = 24 Motif number = 1
Tumour necrosis factor receptor 11A motif I - 1
PCODE ST INT
PLQVTLQVTPPCTQERHYEHLGRC TNR11_MOUSE 24 24
RLQVALQIAPPCTSEKHYEHLGRC TNR11_HUMAN 23 23
TNFACTORR11A2 Length of motif = 12 Motif number = 2
Tumour necrosis factor receptor 11A motif II - 1
PCODE ST INT
PKEAQAYLPSLI TNR11_MOUSE 205 157
PNEPHVYLPGLI TNR11_HUMAN 204 157
TNFACTORR11A3 Length of motif = 26 Motif number = 3
Tumour necrosis factor receptor 11A motif III - 1
PCODE ST INT
TANLWNWVNDACSSLSGNKESSGDRC TNR11_MOUSE 244 27
TANLWHWINEACGRLSGDKESSGDSC TNR11_HUMAN 243 27
TNFACTORR11A4 Length of motif = 22 Motif number = 4
Tumour necrosis factor receptor 11A motif IV - 1
PCODE ST INT
EYTDRPSQPSTGSLLLIQQGSK TNR11_MOUSE 344 74
EYMDRPSQPTDQLLFLTEPGSK TNR11_HUMAN 348 79
TNFACTORR11A5 Length of motif = 16 Motif number = 5
Tumour necrosis factor receptor 11A motif V - 1
PCODE ST INT
ETLAHRDSFAGTAPRF TNR11_MOUSE 564 198
ETLARRDSFAGNGPRF TNR11_HUMAN 573 203
FINAL MOTIF SETS
TNFACTORR11A1 Length of motif = 24 Motif number = 1
Tumour necrosis factor receptor 11A motif I - 1
PCODE ST INT
RLQVALQIAPPCTSEKHYEHLGRC TNR11_HUMAN 23 23
PLQVTLQVTPPCTQERHYEHLGRC TNR11_MOUSE 24 24
TNFACTORR11A2 Length of motif = 12 Motif number = 2
Tumour necrosis factor receptor 11A motif II - 1
PCODE ST INT
PNEPHVYLPGLI TNR11_HUMAN 204 157
PKEAQAYLPSLI TNR11_MOUSE 205 157
TNFACTORR11A3 Length of motif = 26 Motif number = 3
Tumour necrosis factor receptor 11A motif III - 1
PCODE ST INT
TANLWHWINEACGRLSGDKESSGDSC TNR11_HUMAN 243 27
TANLWNWVNDACSSLSGNKESSGDRC TNR11_MOUSE 244 27
TNFACTORR11A4 Length of motif = 22 Motif number = 4
Tumour necrosis factor receptor 11A motif IV - 1
PCODE ST INT
EYMDRPSQPTDQLLFLTEPGSK TNR11_HUMAN 348 79
EYTDRPSQPSTGSLLLIQQGSK TNR11_MOUSE 344 74
TNFACTORR11A5 Length of motif = 16 Motif number = 5
Tumour necrosis factor receptor 11A motif V - 1
PCODE ST INT
ETLARRDSFAGNGPRF TNR11_HUMAN 573 203
ETLAHRDSFAGTAPRF TNR11_MOUSE 564 198
User query: Display/Full Code "TNFACTORR11A"