WORKLIST ENTRIES (1):

PNDRDTASEI View alignment View Structure      Pyridine nucleotide disulphide reductase class-I signature
 Type of fingerprint: COMPOUND with 9  elements
Links:
   PRINTS; PR00469 PNDRDTASEII; PR00368 FADPNR
   PRINTS; PR00370 FMOXYGENASE; PR00420 RNGMNOXGNASE
   INTERPRO; IPR001100
   PFAM; PF00070 pyr_redox
   PDB; 1GRA 3Dinfo; 1LPF 3Dinfo; 1TYP 3Dinfo
   SCOP; 1GRA; 1LPF; 1TYP
   CATH; 1GRA; 1LPF; 1TYP

 Creation date 18-DEC-1995; UPDATE 30-JUN-1999

   1. KUYRIYAN, J., KRISHNA, T.S.R., WONG, L., GUENTHER, B., PAHLER, A.,
   WILLIAMS, C.H. AND MODEL, P.
   Convergent evolution of similar function in two structurally divergent
   enzymes.
   NATURE 352 172-174 (1991).

   2. KUNERT, K.J., CRESSWELL, C.F., SCHMIDT, A., MULLINEAUX, P.M. AND
   FOYER, C.H.
   Variations in the activity of glutathione reductase and the cellular
   glutathione content in relation to sensitivity to methylviologen in
   Escherichia coli.
   ARCH.BIOCHEM.BIOPHYS. 282 233-238 (1990).

   3. SHAMES, S.L., FAIRLAMB, A.H., CERAMI, A. AND WALSH, C.T.
   Purification and characterization of trypanothione reductase from 
   Crithidia fasciculata, a newly discovered member of the family of 
   disulfide-containing flavoprotein reductases.
   BIOCHEMISTRY 25 3519-3526 (1986).

   4. CAROTHERS, D.J., PONS, G. AND PATEL, M.S.
   Dihydrolipoamide dehydrogenase: functional similarities and divergent 
   evolution of the pyridine nucleotide-disulfide oxidoreductases.
   ARCH.BIOCHEM.BIOPHYS. 268 409-25 (1989).

   5. MISRA, T.K.
   Bacterial resistances to inorganic mercury salts and organomercurials.
   PLASMID 27 4-16 (1992).

   6. KARPLUS, P.A. AND SCHULZ, G.E.
   Refined structure of glutathione reductase at 1.54A resolution.
   J.MOL.BIOL. 195 701-729 (1987).

   7. SCHIERING, N., KABSCH, W., MOORE, M.J., DISTEFANO, M.D., WALSH, C.T.
   AND PAI, E.F.
   Structure of the detoxification catalyst mercuric ion reductase from
   Bacillus sp. strain RC607.
   NATURE 352 168-172 (1991).

   8. MATTEVI, A., SCHIERBEEK, A.J. AND HOL, W.G.
   Refined crystal structure of lipoamide dehydrogenase from Azotobacter
   vinelandii at 2.2A resolution. A comparison with the structure of
   glutathione reductase.
   J.MOL.BIOL. 220 975-994 (1991).

   9. KURIYAN, J., KONG, X.P., KRISHNA, T.S., SWEET, R.M., MURGOLO, N.J.,
   FIELD, H., CERAMI, A. AND HENDERSON, G.B.
   X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4A
   resolution.
   PROC.NATL.ACAD.SCI.U.S.A. 88 8764-8768 (1991).

   10. MCKIE, J.H. AND DOUGLAS, K.T.
   Evidence for gene duplication forming similar binding folds for NAD(P)H 
   and FAD in pyridine nucleotide-dependent flavoenzymes.
   FEBS LETT. 279 5-8 (1991).

   11. BENEN, J., VAN BERKEL, W., DIETEREN, N., ARSCOTT, D., WILLIAMS, C., 
   VEEGER, C. AND DE KOK, A.
   Lipoamide dehydrogenase from Azotobacter vinelandii: site-directed 
   mutagenesis of the His450-Glu455 diad. Kinetics of wild-type and mutated 
   enzymes.
   EUR.J.BIOCHEM. 207 487-497 (1992).

   The pyridine nucleotide-disulphide reductases (PNDR) use the isoalloxazine
   ring of FAD to shuttle reducing equivalents from NAD(P)H to a Cys residue
   that is usually a part of a redox-active disulphide bridge. In a second
   step, the reduced disulphide reduces the substrate. On the basis of 
   sequence and structural similarities [1], PNDR can be categorised into 2
   groups. Class I includes glutathione reductase, trypanothione reductase,
   lipoamide dehydrogenase and mercuric reductase. They cover a wide range of
   catalytic functions: glutathione reductase ensures that the cell has 
   enough reduced glutathione to maintain protein thiol groups in the reduced
   state [2]; trypanothione reductase carries out the analogous reaction in 
   trypanosomal cells (trypanothione is an analogue of glutathione) [3]; 
   lipoamide dehydrogenase, the E3 component of alpha-ketoacid dehydrogenase
   multienzyme complex, oxidises the dihydrolypoyl groups of lipoate 
   acyltransferase, and so couples glycolysis to the tricarboxylic acid cycle 
   [4]; and mercuric reductase enables bacteria to detoxify the mercuric ion
   by reducing it to elemental mercury, which evaporates from the cell [5].
   
   To date, the 3D-structures of glutathione reductase [6], mercuric reductase
   [7], lipoamide dehydrogenase [8] and trypanothione reductase [9] have been
   solved. The proteins exist as homodimers, having 4 domains per monomer: an
   N-terminal FAD-binding domain; an NAD(P)H-binding domain; a central domain;
   and a C-terminal interface domain. The FAD- and NAD(P)H-binding domains
   have similar doubly-wound alpha/beta folds, suggesting that these domains
   evolved by gene duplication [10]. The relative orientations of structural
   domains in PNDR may vary significantly. Since the active site occurs between
   domains, this alteration provides a mechanism for adjusting the catalytic 
   properties to meet the special requirements of a particular  reaction.
  
   PNDRDTASEI is a 9-element fingerprint that provides a signature for the 
   PNDR class I family. The fingerprint was derived from an initial alignment
   of 11 sequences: motifs 1 and 4 contain 3 conserved Gly residues and
   correspond to the ADP moiety binding site for FAD and NAD(P) respectively
   (cf. motifs 1 and 3 of signature FADPNR); motif 6 encodes the binding site 
   for the FAD flavin moiety (cf. motif 5 of FADPNR); motif 2 contains 2 Cys
   residues involved in the redox-active disulphide bond, and includes the
   region encoded by PROSITE pattern PYRIDINE_REDOX_1 (PS00076); and motif 9
   contains a conserved His-Glu diad at positions 16 and 21 (mercuric
   reductases have a conserved Tyr instead of His). Site-directed mutagenesis
   experiments on lipoamide dehydrogenase show that mutation of the His-Glu
   diad impairs intramolecular electron transfer between the disulphide/dithiol
   and the FADH-/FAD [11]. Four iterations on OWL26.3 were required to reach 
   convergence, at which point a true set comprising 62 sequences was 
   identified. Numerous partial matches were also found, all of which are
   members of the PNDR and FADPNR families (matching 6-8 motifs, and 5 or
   less motifs respectively). 
  
   An update on SPTR37_9f identified a true set of 102 sequences, and 184
   partial matches.

  SUMMARY INFORMATION
    102 codes involving  9 elements
     13 codes involving  8 elements
      3 codes involving  7 elements
      2 codes involving  6 elements
      4 codes involving  5 elements
     21 codes involving  4 elements
     61 codes involving  3 elements
     80 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    9| 102  102  102  102  102  102  102  102  102  
    8|  11   12   11   13   11   11   12   13   10  
    7|   1    2    2    3    3    2    3    2    3  
    6|   1    2    1    2    1    1    1    2    1  
    5|   4    2    4    4    3    2    0    0    1  
    4|   7    0   17   19   17   20    1    2    1  
    3|  29    1   37   49   18   49    0    0    0  
    2|  38    3   30   32   12   30    3    5    7  
   --+----------------------------------------------
     |   1    2    3    4    5    6    7    8    9  

True positives..
 DLDH_PIG       DLDH_HUMAN     Q14131         DLDH_CANFA     
 O08749         DLDH_TRYBB     O18480         Q41219         
 P90599         P90598         P90597         O81413         
 DLDH_HALVO     DLDH_PEA       DLD2_PSEPU     DLDH_PSEFL     
 Q59822         DLD3_PSEPU     P95596         O00087         
 DLDH_AZOVI     DLDH_YEAST     DLD1_BACSU     DLD1_BACST     
 GSHR_HUMAN     GSHR_BURCE     MERA_ENTAG     O06510         
 MERA_SHIFL     O69236         MERA_PSEAE     O84561         
 MERA_ACICA     Q59299         DLDH_ALCEU     O08449         
 O54319         O66017         MERA_STAAU     MERA_PSEFL     
 Q60154         Q56447         O05610         O69256         
 DLDH_HAEIN     GSHR_PSEAE     O86924         GSHR_ANASP     
 GSHR_HAEIN     Q60151         MERA_THIFE     Q51225         
 DLDH_ECOLI     O86216         GSHR_ECOLI     DLD2_BACSU     
 MERA_SHEPU     O50286         GSHC_ARATH     Q50068         
 TRXB_BOVIN     Q99475         TRXB_HUMAN     O01412         
 O89049         MERA_BACSR     Q59099         GSHR_PEA       
 MERA_STRLI     GSHR_ARATH     Q54101         Q94655         
 O15770         DLD1_PSEPU     TYTR_TRYCR     TYTR_TRYCO     
 TYTR_TRYBB     O66945         O50311         O53747         
 GSHC_SOYBN     Q25861         O34324         O04955         
 TYTR_CRIFA     Q48419         DLDH_MYCPN     DLDH_MYCGE     
 GSHR_YEAST     P91884         Q49111         P73059         
 TRXB_CAEEL     DLDH_ZYMMO     O07212         GSHR_CAEEL     
 O05139         Q02733         P96104         O53355         
 O54279         O54274         
Subfamily:  Codes involving 8 elements
 Subfamily True positives..
 O17953         MERA_ALCSP     Q50994         O13631         
 TYTR_LEIDO     GSHC_PEA       Q48410         GSHR_ORYSA     
 Q93379         O43998         P72740         O07268         
 UDHA_ECOLI     
Subfamily:  Codes involving 7 elements
 Subfamily True positives..
 P78965         P70619         YKGC_ECOLI     
Subfamily:  Codes involving 6 elements
 Subfamily True positives..
 O07927         GSHR_DROME     
Subfamily:  Codes involving 5 elements
 Subfamily True positives..
 Q56283         O27685         O29852         O28421         
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 P95146         Q54453         O27407         O59178         
 O84925         O29847         O83891         O85778         
 NAOX_METJA     O29311         O54079         YDGE_SCHPO     
 BPHG_BURCE     YMER_STAAU     AHPF_SALTY     O58308         
 AHPF_ECOLI     P95034         TRXB_HAEIN     O28718         
 O29603         
Subfamily:  Codes involving 3 elements
 Subfamily True positives..
 O50134         Q58931         BEDA_PSEPU     Q06369         
 TODA_PSEPU     O42346         Q42711         O66266         
 Q54469         TRXB_LISMO     R34K_CLOPA     Q40977         
 O85286         TERA_PSESP     O82864         O29985         
 TRXB_CLOLI     P95569         Q51747         P92947         
 TRXB_EUBAC     Q43497         Q59917         YGBD_ECOLI     
 CAMA_PSEPU     Q51973         Q45081         TRXB_BUCAP     
 RURE_ACICA     Q53125         NADO_THEBR     O65414         
 O06465         O66583         Q57031         O69869         
 O53592         TRXB_MYCTU     NAPE_ENTFA     TRXB_MYCSM     
 Q19655         O67007         AHPF_STAAU     TRXB_ECOLI     
 DHNA_BACSP     O29595         O51851         TRXB_MYCLE     
 Y636_METJA     NASB_BACSU     TRXB_BACSU     TRXB_SCHPO     
 NASD_BACSU     THCD_RHOSO     TRXB_STRCL     TRXB_COXBU     
 O51670         O29006         O29794         DHTM_METME     
 NAOX_MYCGE     
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 RURE_PSEOL     Q56285         BNZD_PSEPU     O24679         
 Q52386         O69798         Q52437         O29966         
 TRXB_HELPY     BAIH_EUBSP     O69367         O26804         
 O29694         P72259         Q18213         O84101         
 YM23_YEAST     O08340         Q46377         O52582         
 TRXB_TREPA     DHNA_BACSU     O59368         O66790         
 O54535         O85962         O87278         O65946         
 O29594         NDI1_YEAST     TRXB_BORBU     O28809         
 NAOX_ENTFA     TRXB_NEUCR     TRXB_YEAST     Q59160         
 P73829         O52935         NIRB_KLEPN     O58643         
 GLTD_AZOBR     FRDA_WOLSU     Q24834         Q43128         
 Q46811         NIRB_ECOLI     TRXB_PENCH     O53674         
 O53370         Q49924         AEGA_ECOLI     HCAD_ECOLI     
 NAOX_MYCPN     YHQ6_YEAST     O61143         P72762         
 O59088         O50431         GLTD_ECOLI     Q50616         
 P76440         O33474         Q19428         Q18031         
 GLPD_MYCLE     O07168         O59547         O32907         
 GLPD_SYNY3     P95160         O80918         O53486         
 O67845         Q59158         


  PROTEIN TITLES
   DLDH_PIG         DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   DLDH_HUMAN       DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   Q14131           DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   DLDH_CANFA       DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   O08749           DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   DLDH_TRYBB       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) - TRYPANOSOMA BR
   O18480           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3) - MANDUCA S
   Q41219           FERRIC LEGHEMOGLOBIN REDUCTASE - GLYCINE MAX (SOYBEAN).
   P90599           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) - TRYPANOSOMA CR
   P90598           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) - TRYPANOSOMA CR
   P90597           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) - TRYPANOSOMA CR
   O81413           FERRIC LEGHEMOGLOBIN REDUCTASE-2 PRECURSOR - GLYCINE MAX (SO
   DLDH_HALVO       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) - HALOBACTERIUM 
   DLDH_PEA         DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   DLD2_PSEPU       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   DLDH_PSEFL       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   Q59822           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   DLD3_PSEPU       DIHYDROLIPOAMIDE DEHYDROGENASE 3 (EC 1.8.1.4) (LPD-3) - PSEU
   P95596           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   O00087           DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   DLDH_AZOVI       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   DLDH_YEAST       DIHYDROLIPOAMIDE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 
   DLD1_BACSU       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   DLD1_BACST       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   GSHR_HUMAN       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - HOMO SAPIE
   GSHR_BURCE       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - BURKHOLDER
   MERA_ENTAG       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - ENTERO
   O06510           MERCURIC REDUCTASE - ENTEROBACTER CLOACAE.
   MERA_SHIFL       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - SHIGEL
   O69236           MERCURIC REDUCTASE - BACILLUS CEREUS.
   MERA_PSEAE       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - PSEUDO
   O84561           LIPOAMIDE DEHYDROGENASE - CHLAMYDIA TRACHOMATIS.
   MERA_ACICA       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - ACINET
   Q59299           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (LIPOAMIDE REDUC
   DLDH_ALCEU       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   O08449           MERCURIC REDUCTASE (EC 1.16.1.1) (MERCURY (II) REDUCTASE) - 
   O54319           MERCURIC REDUCTASE - THIOBACILLUS SP.
   O66017           MERA - PSEUDOMONAS STUTZERI (PSEUDOMONAS PERFECTOMARINA).
   MERA_STAAU       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - STAPHY
   MERA_PSEFL       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - PSEUDO
   Q60154           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (LIPOAMIDE REDUC
   Q56447           MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - UNIDEN
   O05610           MERCURIC ION REDUCTASE - PSEUDOMONAS SP.
   O69256           MERCURIC REDUCTASE - BACILLUS MEGATERIUM.
   DLDH_HAEIN       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   GSHR_PSEAE       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - PSEUDOMONA
   O86924           ORF 4 PROTEIN - SPHINGOMONAS SP. RW5.
   GSHR_ANASP       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - ANABAENA S
   GSHR_HAEIN       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - HAEMOPHILU
   Q60151           GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GLUTATHIONE REDUCTASE (N
   MERA_THIFE       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - THIOBA
   Q51225           OUTER MEMBRANE PROTEIN P64K OR PM-6 - NEISSERIA MENINGITIDIS
   DLDH_ECOLI       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   O86216           MERCURIC REDUCTASE - EXIGUOBACTERIUM SP.
   GSHR_ECOLI       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - ESCHERICHI
   DLD2_BACSU       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   MERA_SHEPU       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - SHEWAN
   O50286           LIPOAMIDE DEHYDROGENASE - VIBRIO PARAHAEMOLYTICUS.
   GSHC_ARATH       GLUTATHIONE REDUCTASE, CHLOROPLAST PRECURSOR (EC 1.6.4.2) (G
   Q50068           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) - MYCOBACTERIUM 
   TRXB_BOVIN       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - BOS TAURUS (BOVINE).
   Q99475           KM-102-DERIVED REDUCTASE-LIKE FACTOR (THIOREDOXIN REDUCTASE)
   TRXB_HUMAN       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - HOMO SAPIENS (HUMAN).
   O01412           GLUTATHIONE REDUCTASE - ONCHOCERCA VOLVULUS.
   O89049           THIOREDOXIN REDUCTASE - RATTUS NORVEGICUS (RAT).
   MERA_BACSR       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - BACILL
   Q59099           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (LIPOAMIDE REDUC
   GSHR_PEA         GLUTATHIONE REDUCTASE, CYTOSOLIC (EC 1.6.4.2) (GR) (GRASE) (
   MERA_STRLI       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - STREPT
   GSHR_ARATH       GLUTATHIONE REDUCTASE, CYTOSOLIC (EC 1.6.4.2) (GR) (GRASE) (
   Q54101           NADH-FERREDOXIN OXIDOREDUCTASE - SACCHAROPOLYSPORA ERYTHRAEA
   Q94655           GLUTATHIONE REDUCTASE - PLASMODIUM FALCIPARUM.
   O15770           GLUTATHIONE REDUCTASE - PLASMODIUM FALCIPARUM.
   DLD1_PSEPU       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   TYTR_TRYCR       TRYPANOTHIONE REDUCTASE (EC 1.6.4.8) (TR) (N1,N8- BIS(GLUTAT
   TYTR_TRYCO       TRYPANOTHIONE REDUCTASE (EC 1.6.4.8) (TR) (N1,N8- BIS(GLUTAT
   TYTR_TRYBB       TRYPANOTHIONE REDUCTASE (EC 1.6.4.8) (TR) (N1,N8- BIS(GLUTAT
   O66945           DIHYDROLIPOAMIDE DEHYDROGENASE - AQUIFEX AEOLICUS.
   O50311           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   O53747           PUTATIVE DIHYDROLIPOAMIDE DEHYDROGENASE - MYCOBACTERIUM TUBE
   GSHC_SOYBN       GLUTATHIONE REDUCTASE, CHLOROPLAST PRECURSOR (EC 1.6.4.2) (G
   Q25861           GLUTATHIONE REDUCTASE - PLASMODIUM FALCIPARUM.
   O34324           LIPOAMIDE DEHYDROGENASE COMPONENT OF PYRUVATE DEHYDROGENASE 
   O04955           GLUTATHIONE REDUCTASE, CYTOSOLIC (EC 1.6.4.2) (GR) - BRASSIC
   TYTR_CRIFA       TRYPANOTHIONE REDUCTASE (EC 1.6.4.8) (TR) (N1,N8- BIS(GLUTAT
   Q48419           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   DLDH_MYCPN       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   DLDH_MYCGE       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   GSHR_YEAST       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - SACCHAROMY
   P91884           GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GLUTATHIONE REDUCTASE (N
   Q49111           LIPOAMIDE DEHYDROGENASE COMPONENT OF PYRUVATE DEHYDROGENASE 
   P73059           MERCURIC REDUCTASE - SYNECHOCYSTIS SP. (STRAIN PCC 6803).
   TRXB_CAEEL       PROBABLE THIOREDOXIN REDUCTASE (EC 1.6.4.5) - CAENORHABDITIS
   DLDH_ZYMMO       DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   O07212           HYPOTHETICAL 50.8 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
   GSHR_CAEEL       PROBABLE GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - C
   O05139           SOLUBLE PYRIDINE NUCLEOTIDE TRANSHYDROGENASE - PSEUDOMONAS F
   Q02733           LPB14P - SACCHAROMYCES CEREVISIAE (BAKER'S YEAST).
   P96104           DIHYDROLIPOYL TRANSACETYLASE AND LIPOAMIDE DEHYDROGENASE OF 
   O53355           DIHYDROLIPOAMIDE DEHYDROGENASE - MYCOBACTERIUM TUBERCULOSIS.
   O54279           ORF454 PROTEIN - STAPHYLOCOCCUS SCIURI.
   O54274           ORF503 PROTEIN - STAPHYLOCOCCUS SCIURI.
 
   O17953           LLC1.3 PROTEIN - CAENORHABDITIS ELEGANS.
   MERA_ALCSP       MERCURIC REDUCTASE (EC 1.16.1.1) (HG(II) REDUCTASE) - ALCALI
   Q50994           SUCAB-LPD OPERON, SUCB AND LPD GENES, COMPLETE CDS, SUCA GEN
   O13631           GLUTATHIONE REDUCTASE - SCHIZOSACCHAROMYCES POMBE (FISSION Y
   TYTR_LEIDO       TRYPANOTHIONE REDUCTASE (EC 1.6.4.8) (TR) (N1,N8- BIS(GLUTAT
   GSHC_PEA         GLUTATHIONE REDUCTASE, CHLOROPLAST/MITOCHONDRIAL PRECURSOR (
   Q48410           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   GSHR_ORYSA       GLUTATHIONE REDUCTASE, CYTOSOLIC (EC 1.6.4.2) (GR) (GRASE) -
   Q93379           C46F11.2 PROTEIN - CAENORHABDITIS ELEGANS.
   O43998           GLUTATHIONE REDUCTASE HOMOLOG - TOXOPLASMA GONDII.
   P72740           DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) (E3 COMPONENT OF
   O07268           MERCURIC REDUCTASE - MYCOBACTERIUM TUBERCULOSIS.
   UDHA_ECOLI       UNKNOWN DEHYDROGENASE A (EC 1.-.-.-) - ESCHERICHIA COLI.
 
   P78965           GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GLUTATHIONE REDUCTASE (N
   P70619           GLUTATHIONE REDUCTASE - RATTUS NORVEGICUS (RAT).
   YKGC_ECOLI       PROBABLE PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE IN EAE
 
   O07927           GLUTATHIONE REDUCTASE HOMOLOG - MYCOBACTERIUM TUBERCULOSIS.
   GSHR_DROME       GLUTATHIONE REDUCTASE (EC 1.6.4.2) (GR) (GRASE) - DROSOPHILA
 
   Q56283           ORF-1 - THIOBACILLUS FERROOXIDANS.
   O27685           DIHYDROLIPOAMIDE DEHYDROGENASE - METHANOBACTERIUM THERMOAUTO
   O29852           NADH OXIDASE (NOXA-2) - ARCHAEOGLOBUS FULGIDUS.
   O28421           NADH OXIDASE (NOXA-5) - ARCHAEOGLOBUS FULGIDUS.
 
   P95146           HYPOTHETICAL 43.6 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
   Q54453           H2O-FORMING NADH OXIDASE - STREPTOCOCCUS MUTANS.
   O27407           NADH OXIDASE - METHANOBACTERIUM THERMOAUTOTROPHICUM.
   O59178           440AA LONG HYPOTHETICAL NADH OXIDASE - PYROCOCCUS HORIKOSHII
   O84925           NADH OXIDASE - STREPTOCOCCUS PNEUMONIAE.
   O29847           NADH OXIDASE (NOXA-3) - ARCHAEOGLOBUS FULGIDUS.
   O83891           NADH OXIDASE - TREPONEMA PALLIDUM.
   O85778           PUTATIVE FERREDOXIN REDUCTASE MOCF - RHIZOBIUM LEGUMINOSARUM
   NAOX_METJA       PUTATIVE NADH OXIDASE (EC 1.6.99.3) (NOXASE) - METHANOCOCCUS
   O29311           NADH OXIDASE (NOXA-4) - ARCHAEOGLOBUS FULGIDUS.
   O54079           THIOREDOXIN REDUCTASE (EC 1.6.4.5) - STAPHYLOCOCCUS AUREUS.
   YDGE_SCHPO       PUTATIVE FLAVOPROTEIN C26F1.14C - SCHIZOSACCHAROMYCES POMBE 
   BPHG_BURCE       BIPHENYL DIOXYGENASE SYSTEM FERREDOXIN--NAD(+) REDUCTASE COM
   YMER_STAAU       HYPOTHETICAL 19.7 KD PROTEIN IN MERCURIC RESISTANCE OPERON -
   AHPF_SALTY       ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT F (EC 1.6.4.-) (ALKYL 
   O58308           445AA LONG HYPOTHETICAL NADH OXIDASE - PYROCOCCUS HORIKOSHII
   AHPF_ECOLI       ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT F (EC 1.6.4.-) (ALKYL 
   P95034           HYPOTHETICAL 43.0 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
   TRXB_HAEIN       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - HAEMOPHILUS INFLUENZAE.
   O28718           THIOREDOXIN REDUCTASE (TRXB) - ARCHAEOGLOBUS FULGIDUS.
   O29603           CONSERVED HYPOTHETICAL PROTEIN - ARCHAEOGLOBUS FULGIDUS.
 
   O50134           336AA LONG HYPOTHETICAL THIOREDOXIN REDUCTASE - PYROCOCCUS H
   Q58931           HYPOTHETICAL PROTEIN MJ1536 - METHANOCOCCUS JANNASCHII.
   BEDA_PSEPU       BENZENE 1,2-DIOXYGENASE SYSTEM FERREDOXIN--NAD(+) REDUCTASE 
   Q06369           NADH OXIDASE - AMPHIBACILLUS XYLANUS.
   TODA_PSEPU       TOLUENE 1,2-DIOXYGENASE SYSTEM FERREDOXIN--NAD(+) REDUCTASE 
   O42346           TAMEGOLOH - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   Q42711           MONODEHYDROASCORBATE REDUCTASE (EC 1.6.5.4) - CUCUMIS SATIVU
   O66266           NADH OXIDASE/ALKYL HYDROPEROXIDASE REDUCTASE - STREPTOCOCCUS
   Q54469           NADH OXIDASE - STREPTOCOCCUS MUTANS.
   TRXB_LISMO       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - LISTERIA MONOCYTOGENES.
   R34K_CLOPA       34.2 KD PROTEIN IN RUBREDOXIN OPERON (EC 1.6.4.-) (ORF A) - 
   Q40977           MONODEHYDROASCORBATE REDUCTASE - PISUM SATIVUM (GARDEN PEA).
   O85286           INITIAL DIOXYGENASE REDUCTASE SUBUNIT - SPHINGOMONAS SP. CB3
   TERA_PSESP       TERPREDOXIN REDUCTASE (EC 1.18.1.-) - PSEUDOMONAS SP.
   O82864           ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT F (EC 1.6.4.-) - PSEUD
   O29985           NADH OXIDASE (NOXA-1) - ARCHAEOGLOBUS FULGIDUS.
   TRXB_CLOLI       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - CLOSTRIDIUM LITORALE (B
   P95569           ISOPROPYLBENZENE-2,3-DIOXYGENASE - PSEUDOMONAS SP.
   Q51747           FERREDOXIN REDUCTASE OF CUMENE DIOXYGENASE - PSEUDOMONAS FLU
   P92947           MONODEHYDROASCORBATE REDUCTASE - ARABIDOPSIS THALIANA (MOUSE
   TRXB_EUBAC       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - EUBACTERIUM ACIDAMINOPH
   Q43497           ASCORBATE FREE RADICAL REDUCTASE - LYCOPERSICON ESCULENTUM (
   Q59917           NADH OXIDASE (EC 1.6.99.3) (NOXASE) - TREPONEMA HYODYSENTERI
   YGBD_ECOLI       HYPOTHETICAL 41.4 KD PROTEIN IN SRLQ-HYPF INTERGENIC REGION 
   CAMA_PSEPU       PUTIDAREDOXIN REDUCTASE (EC 1.18.1.-) - PSEUDOMONAS PUTIDA.
   Q51973           P-CUMATE DIOXYGENASE FERREDOXIN REDUCTASE SUBUNIT - PSEUDOMO
   Q45081           MOPA - BURKHOLDERIA CEPACIA (PSEUDOMONAS CEPACIA).
   TRXB_BUCAP       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - BUCHNERA APHIDICOLA.
   RURE_ACICA       RUBREDOXIN-NAD(+) REDUCTASE (EC 1.18.1.1) - ACINETOBACTER CA
   Q53125           BIPHENYL DIOXYGENASE - RHODOCOCCUS SP.
   NADO_THEBR       NADH OXIDASE (EC 1.-.-.-) - THERMOANAEROBACTER BROCKII (THER
   O65414           NADH DEHYDROGENASE LIKE PROTEIN - ARABIDOPSIS THALIANA (MOUS
   O06465           ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT F (EC 1.6.4.-) - XANTH
   O66583           NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (NAD(P)H) - AQUIFE
   Q57031           FERREDOXIN REDUCTASE BPH - RHODOCOCCUS GLOBERULUS, RHODOCOCC
   O69869           PUTATIVE FLAVOPROTEIN OXIDOREDUCTASE - STREPTOMYCES COELICOL
   O53592           THIOREDOXIN REDUCTASE (EC 1.6.4.5) (TR) - MYCOBACTERIUM TUBE
   TRXB_MYCTU       THIOREDOXIN REDUCTASE (EC 1.6.4.5) (TR) - MYCOBACTERIUM TUBE
   NAPE_ENTFA       NADH PEROXIDASE (EC 1.11.1.1) (NPXASE) - ENTEROCOCCUS FAECAL
   TRXB_MYCSM       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - MYCOBACTERIUM SMEGMATIS
   Q19655           SIMILAR TO OXIDOREDUCTASE - CAENORHABDITIS ELEGANS.
   O67007           NADH OXIDASE - AQUIFEX AEOLICUS.
   AHPF_STAAU       ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT F (EC 1.6.4.-) - STAPH
   TRXB_ECOLI       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - ESCHERICHIA COLI.
   DHNA_BACSP       NADH DEHYDROGENASE (EC 1.6.99.3) (ALKYL HYDROPEROXIDE REDUCT
   O29595           HETERODISULFIDE REDUCTASE, SUBUNIT A/METHYLVIOLOGEN REDUCING
   O51851           ISOPROPYLBENZENE DIOXYGENASE, FERREDOXIN REDUCTASE SUBUNIT -
   TRXB_MYCLE       BIFUNCTIONAL THIOREDOXIN REDUCTASE/THIOREDOXIN [INCLUDES: TH
   Y636_METJA       HYPOTHETICAL PROTEIN MJ0636 - METHANOCOCCUS JANNASCHII.
   NASB_BACSU       ASSIMILATORY NITRATE REDUCTASE ELECTRON TRANSFER SUBUNIT - B
   TRXB_BACSU       THIOREDOXIN REDUCTASE (EC 1.6.4.5) (GENERAL STRESS PROTEIN 3
   TRXB_SCHPO       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - SCHIZOSACCHAROMYCES POM
   NASD_BACSU       NITRITE REDUCTASE [NAD(P)H] (EC 1.6.6.4) - BACILLUS SUBTILIS
   THCD_RHOSO       RHODOCOXIN REDUCTASE (EC 1.18.1.-) - RHODOCOCCUS SP. (STRAIN
   TRXB_STRCL       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - STREPTOMYCES CLAVULIGER
   TRXB_COXBU       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - COXIELLA BURNETII.
   O51670           NADH OXIDASE, WATER-FORMING (NOX) - BORRELIA BURGDORFERI (LY
   O29006           NADH OXIDASE (NOXB-2) - ARCHAEOGLOBUS FULGIDUS.
   O29794           NADH OXIDASE (NOXB-1) - ARCHAEOGLOBUS FULGIDUS.
   DHTM_METME       TRIMETHYLAMINE DEHYDROGENASE (EC 1.5.99.7) (TMADH) - METHYLO
   NAOX_MYCGE       PROBABLE NADH OXIDASE (EC 1.6.99.3) (NOXASE) - MYCOPLASMA GE
 
   RURE_PSEOL       RUBREDOXIN-NAD(+) REDUCTASE (EC 1.18.1.1) - PSEUDOMONAS OLEO
   Q56285           ORF-3 - THIOBACILLUS FERROOXIDANS.
   BNZD_PSEPU       BENZENE 1,2-DIOXYGENASE SYSTEM FERREDOXIN--NAD(+) REDUCTASE 
   O24679           TECA4 - BURKHOLDERIA SP.
   Q52386           CHLOROBENZENE DIOXYGENASE, NADH-FERREDOXIN REDUCTASE - PSEUD
   O69798           REDUCTASE - RALSTONIA SP.
   Q52437           FERREDOXIN REDUCTASE - PSEUDOMONAS SP.
   O29966           SARCOSINE OXIDASE, SUBUNIT ALPHA (SOXA) - ARCHAEOGLOBUS FULG
   TRXB_HELPY       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - HELICOBACTER PYLORI (CA
   BAIH_EUBSP       NADH-DEPENDENT FLAVIN OXIDOREDUCTASE (EC 1.-.-.-) - EUBACTER
   O69367           FERREDOXIN REDUCTASE - RHODOCOCCUS ERYTHROPOLIS.
   O26804           THIOREDOXIN REDUCTASE - METHANOBACTERIUM THERMOAUTOTROPHICUM
   O29694           FLAVOPROTEIN REDUCTASE - ARCHAEOGLOBUS FULGIDUS.
   P72259           ISOPROPYLBENZENE 2,3-DIOXYGENASE - RHODOCOCCUS ERYTHROPOLIS.
   Q18213           C26D10.3 PROTEIN - CAENORHABDITIS ELEGANS.
   O84101           THIOREDOXIN REDUCTASE - CHLAMYDIA TRACHOMATIS.
   YM23_YEAST       HYPOTHETICAL 62.8 KD PROTEIN IN RPS16A-TIF34 INTERGENIC REGI
   O08340           GLUTAMATE SYNTHASE (EC 1.4.1.13) (GLUTAMATE SYNTHASE (NADPH)
   Q46377           BIPHENYL DIOXYGENASE FERREDOXIN REDUCTASE - COMAMONAS TESTOS
   O52582           COENZYME A DISULFIDE REDUCTASE - STAPHYLOCOCCUS AUREUS.
   TRXB_TREPA       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - TREPONEMA PALLIDUM.
   DHNA_BACSU       NADH DEHYDROGENASE (EC 1.6.99.3) (ALKYL HYDROPEROXIDE REDUCT
   O59368           482AA LONG HYPOTHETICAL D-NOPALINE DEHYDROGENASE - PYROCOCCU
   O66790           THIOREDOXIN REDUCTASE - AQUIFEX AEOLICUS.
   O54535           SIMILAR TO MYCOBACTERIUM LEPRAE THIOREDOXIN REDUCTASE - HALO
   O85962           FERREDOXIN REDUCTASE SUBUNIT AROMATIC OXYGENASE - SPHINGOMON
   O87278           STCD PROTEIN - SINORHIZOBIUM MELILOTI.
   O65946           REDA2 PROTEIN - SPHINGOMONAS SP.
   O29594           HETERODISULFIDE REDUCTASE, SUBUNIT A (HDRA-1) - ARCHAEOGLOBU
   NDI1_YEAST       ROTENONE-INSENSITIVE NADH-UBIQUINONE OXIDOREDUCTASE PRECURSO
   TRXB_BORBU       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - BORRELIA BURGDORFERI (L
   O28809           FUMARATE REDUCTASE, FLAVOPROTEIN SUBUNIT (FDRA) (MYCOBACTERI
   NAOX_ENTFA       NADH OXIDASE (EC 1.6.99.3) (NOXASE) - ENTEROCOCCUS FAECALIS 
   TRXB_NEUCR       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - NEUROSPORA CRASSA.
   TRXB_YEAST       THIOREDOXIN REDUCTASE 1 (EC 1.6.4.5) - SACCHAROMYCES CEREVIS
   Q59160           OOXA (EC 1.5.1.19) (D-NOPALINE DEHYDROGENASE) (D-NOPALINE SY
   P73829           HYPOTHETICAL 48.2 KD PROTEIN - SYNECHOCYSTIS SP. (STRAIN PCC
   O52935           2-ENOATE REDUCTASE (EC 1.3.1.31) - MOORELLA THERMOACETICA (C
   NIRB_KLEPN       NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT (EC 1.6.6.4) - KLE
   O58643           397AA LONG HYPOTHETICAL NADH OXIDASE - PYROCOCCUS HORIKOSHII
   GLTD_AZOBR       GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN (EC 1.4.1.13) (GLUTAM
   FRDA_WOLSU       FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT (EC 1.3.99.1) - WOLI
   Q24834           DISULPHIDE OXIDOREDUCTASE - ENTAMOEBA HISTOLYTICA.
   Q43128           PLASMA MEMBRANE H(+)-ATPASE ISOFORM AHA10 - ARABIDOPSIS THAL
   Q46811           WAS O492P AND O826P BEFORE SPLICE - ESCHERICHIA COLI.
   NIRB_ECOLI       NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT (EC 1.6.6.4) - ESC
   TRXB_PENCH       THIOREDOXIN REDUCTASE (EC 1.6.4.5) - PENICILLIUM CHRYSOGENUM
   O53674           NITRITE REDUCTASE LARGE SUBUNIT - MYCOBACTERIUM TUBERCULOSIS
   O53370           FLAVOPROTEIN SUBUNIT OF SUCCINATE DEHYDROGENASE - MYCOBACTER
   Q49924           L308_F3_120 - MYCOBACTERIUM LEPRAE.
   AEGA_ECOLI       AEGA PROTEIN - ESCHERICHIA COLI.
   HCAD_ECOLI       DIGOXIGENIN SYSTEM FERREDOXIN--NAD(+) REDUCTASE COMPONENT (E
   NAOX_MYCPN       PROBABLE NADH OXIDASE (EC 1.6.99.3) (NOXASE) - MYCOPLASMA PN
   YHQ6_YEAST       THIOREDOXIN REDUCTASE 2, MITOCHONDRIAL PRECURSOR (EC 1.6.4.5
   O61143           NAD(P)H-DEPENDENT GLUTAMATE SYNTHASE - PLASMODIUM FALCIPARUM
   P72762           NADH-GLUTAMATE SYNTHASE SMALL SUBUNIT - SYNECHOCYSTIS SP. (S
   O67845           GLUTAMATE SYNTHASE SMALL SUBUNIT GLTD - AQUIFEX AEOLICUS.
   Q59158           NOXA (EC 1.5.1.19) (D-NOPALINE DEHYDROGENASE) (D-NOPALINE SY
   O59088           493AA LONG HYPOTHETICAL PROTEIN - PYROCOCCUS HORIKOSHII.
   O50431           2,4-DIENOYL-COA REDUCTASE - MYCOBACTERIUM TUBERCULOSIS.
   GLTD_ECOLI       GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN (EC 1.4.1.13) (GLUTAM
   Q50616           HYPOTHETICAL 51.0 KD PROTEIN CY1A11.26C - MYCOBACTERIUM TUBE
   P76440           FROM BASES 2222950 TO 2234667 (SECTION 193 OF 400) OF THE CO
   O33474           GLUTAMATE SYNTHASE - PYROCOCCUS SP.
   Q19428           F36H1.6 PROTEIN - CAENORHABDITIS ELEGANS.
   GLPD_MYCLE       GLYCEROL-3-PHOSPHATE DEHYDROGENASE (EC 1.1.99.5) - MYCOBACTE
   O07168           GLPD2 - MYCOBACTERIUM TUBERCULOSIS.
   O59547           476AA LONG HYPOTHETICAL GLUTAMATE SYNTHASE SMALL CHAIN - PYR
   O32907           DEHYDROGENASE - MYCOBACTERIUM LEPRAE.
   GLPD_SYNY3       GLYCEROL-3-PHOSPHATE DEHYDROGENASE (EC 1.1.99.5) - SYNECHOCY
   P95160           HYPOTHETICAL 49.6 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
   O80918           T19C21.18 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
   O53486           HYPOTHETICAL 29.1 KD PROTEIN - MYCOBACTERIUM TUBERCULOSIS.
   Q18031           NAD(P) TRANSHYDROGENASE (EC 1.6.1.1) (PYRIDINE NUCLEOTIDE TR

SCAN HISTORY OWL26_3 4 500 NSINGLE SPTR37_9f 4 450 NSINGLE INITIAL MOTIF SETS PNDRDTASEI1 Length of motif = 23 Motif number = 1 Pyridine nucleotide disulphide reductase-I motif I - 1 PCODE ST INT DVTVIGSGPGGYVAAIKAAQLGF DLDH_HUMAN 43 43 DVIVIGAGPGGYVAAIKSAQLGL DLDH_AZOVI 6 6 DYLVIGGGSGGLASARRAAELGA GSHR_HUMAN 22 22 DLFTIGAGSGGVRASRFASNFGA GSHR_PEA 75 75 DLFVIGAGSGGVRAARFAAGFGA GSHR_PSEAE 6 6 DYIAIGGGSGGIASINRAAMYGQ GSHR_ECOLI 6 6 DYIAIGGGSGGIASLNRAASYGK GSHR_HAEIN 6 6 DLVVIGAGSGGLEAAWNAATLYK TYTR_TRYCR 7 7 DLVVIGAGSGGLEAGWNAASLHK TYTR_CRIFA 6 6 DYIIIGSGGAAFSSAIEAVALNA MERA_BACSR 171 171 QVAVIGSGGAAMAAALKAVEQGA MERA_PSEAE 100 100 PNDRDTASEI2 Length of motif = 16 Motif number = 2 Pyridine nucleotide disulphide reductase-I motif II - 1 PCODE ST INT LGGTCLNVGCIPSKAL DLDH_HUMAN 76 10 LGGTCLNVGCIPSKAL DLDH_AZOVI 45 16 LGGTCVNVGCVPKKVM GSHR_HUMAN 54 9 VGGTCVIRGCVPKKLL GSHR_PEA 117 19 LGGTCVNVGCVPKKLL GSHR_PSEAE 38 9 LGGTCVNVGCVPKKVM GSHR_ECOLI 38 9 LGGTCVNVGCVPKKVM GSHR_HAEIN 38 9 LGGTCVNVGCVPKKLM TYTR_TRYCR 49 19 LGGTCVNVGCVPKKLM TYTR_CRIFA 48 19 VGGTCVNVGCVPSKTL MERA_BACSR 203 9 IGGTCVNVGCVPSKIM MERA_PSEAE 132 9 PNDRDTASEI3 Length of motif = 10 Motif number = 3 Pyridine nucleotide disulphide reductase-I motif III - 1 PCODE ST INT ILIATGSEVT DLDH_HUMAN 179 87 VILASGSKPV DLDH_AZOVI 147 86 ILIATGGMPS GSHR_HUMAN 152 82 ILVSVGGRPF GSHR_PEA 214 81 ILVATGGWPQ GSHR_PSEAE 134 80 ILIATGGRPS GSHR_ECOLI 135 81 ILIATGGRPY GSHR_HAEIN 140 86 ILLASGSWPH TYTR_TRYCR 157 92 ILLATGSWPQ TYTR_CRIFA 156 92 FLIATGASST MERA_BACSR 300 81 CLVATGASPA MERA_PSEAE 236 88 PNDRDTASEI4 Length of motif = 26 Motif number = 4 Pyridine nucleotide disulphide reductase-I motif IV - 1 PCODE ST INT KMVVIGAGVIGVELGSVWQRLGADVT DLDH_HUMAN 215 26 KLGVIGAGVIGLELGSVWARLGAEVT DLDH_AZOVI 183 26 RSVIVGAGYIAVEMAGILSALGSKTS GSHR_HUMAN 189 27 KIAIVGGGYIALEFAGIFNGLKSEVH GSHR_PEA 248 24 RVLVVGGGYIAVEFASIFNGLGAETT GSHR_PSEAE 168 24 RVAVVGAGYIAVELAGVINGLGAKTH GSHR_ECOLI 169 24 RAAVIGAGYIAVELSGVLNSLGVETH GSHR_HAEIN 174 24 RVLTVGGGFISVEFAGIFNAYKPKDG TYTR_TRYCR 191 24 RALCVGGGYISIEFAGIFNAYKARGG TYTR_CRIFA 190 24 RLTVIGSGYIGMELGQLFHNLGSEVT MERA_BACSR 336 26 RLAVIGSSVVALELAQAFARLGSKVT MERA_PSEAE 272 26 PNDRDTASEI5 Length of motif = 15 Motif number = 5 Pyridine nucleotide disulphide reductase-I motif V - 1 PCODE ST INT DVLLVCIGRRPFTKN DLDH_HUMAN 307 66 DKLIVAVGRRPVTTD DLDH_AZOVI 271 62 DCLLWAIGRVPNTKD GSHR_HUMAN 283 68 SHIMFATGRSPNTKD GSHR_PEA 334 60 DCVFYATGRRPMLDD GSHR_PSEAE 254 60 DCLIWAIGREPANDN GSHR_ECOLI 255 60 DCVIWAAGRVPTTDK GSHR_HAEIN 260 60 DLVMMAIGRSPRTKD TYTR_TRYCR 280 63 DVVMLAIGRVPRSQT TYTR_CRIFA 279 63 EQLLIATGRKPIQTS MERA_BACSR 424 62 DKLLVATGRTPNTRS MERA_PSEAE 355 57 PNDRDTASEI6 Length of motif = 8 Motif number = 6 Pyridine nucleotide disulphide reductase-I motif VI - 1 PCODE ST INT IYAIGDVV DLDH_HUMAN 350 28 VYAIGDVV DLDH_AZOVI 314 28 IYAVGDVC GSHR_HUMAN 326 28 IWAIGDAT GSHR_PEA 377 28 ILALGDVI GSHR_PSEAE 297 28 IYAVGDNT GSHR_ECOLI 298 28 IYAVGDII GSHR_HAEIN 303 28 IYAIGDVT TYTR_TRYCR 322 27 IYAIGDVT TYTR_CRIFA 322 28 IYSAGDVT MERA_BACSR 467 28 IYAAGDCT MERA_PSEAE 398 28 PNDRDTASEI7 Length of motif = 22 Motif number = 7 Pyridine nucleotide disulphide reductase-I motif VII - 1 PCODE ST INT DYNCVPSVIYTHPEVAWVGKSE DLDH_HUMAN 385 27 NYDLIPAVIYTHPEIAGVGKTE DLDH_AZOVI 349 27 DYNNIPTVVFSHPPIGTVGLTE GSHR_HUMAN 363 29 DYRAIPSAVFSQPPIGGVGLTE GSHR_PEA 413 28 DYKLIPTAVFSLPNIGTVGLTE GSHR_PSEAE 334 29 DYSNIPTVVFSHPPIGTVGLTE GSHR_ECOLI 335 29 DYSLVPTVVFSHPPIGTVGLTE GSHR_HAEIN 341 30 DHTRVASAVFSIPPIGTCGLIE TYTR_TRYCR 358 28 DHTKVACAVFSIPPMGVCGYVE TYTR_CRIFA 358 28 NLEVVPGVTFTSPSIATVGLTE MERA_BACSR 503 28 DLTAMPAVVFTDPQVATVGYSE MERA_PSEAE 433 27 PNDRDTASEI8 Length of motif = 16 Motif number = 8 Pyridine nucleotide disulphide reductase-I motif VIII - 1 PCODE ST INT VLGAHILGPGAGEMVN DLDH_HUMAN 450 43 VLGVHVIGPSAAELVQ DLDH_AZOVI 414 43 VVGIHMQGLGCDEMLQ GSHR_HUMAN 430 45 VLGLHMCGEDAAEIAQ GSHR_PEA 478 43 VLGCHMVGAEAGEILQ GSHR_PSEAE 399 43 IVGIHGIGFGMDEMLQ GSHR_ECOLI 402 45 VVGLHGIGFGVDEMIQ GSHR_HAEIN 408 45 VLGVHLLGDNAPEIIQ TYTR_TRYCR 424 44 VLGVHMLGDSSPEIIQ TYTR_CRIFA 424 44 VLGAHVVAENAGDVIY MERA_BACSR 568 43 LIGVQAVAPEAGELIQ MERA_PSEAE 498 43 PNDRDTASEI9 Length of motif = 21 Motif number = 9 Pyridine nucleotide disulphide reductase-I motif IX - 1 PCODE ST INT EYGASCEDIARVCHAHPTLSE DLDH_HUMAN 472 6 EFGTSAEDLGMMVFAHPALSE DLDH_AZOVI 436 6 KMGATKADFDNTVAIHPTSSE GSHR_HUMAN 452 6 KAGLTKADFDATVGIHPTAAE GSHR_PEA 500 6 KAGATKQAFDETIGIHPTAAE GSHR_PSEAE 421 6 KMGATKKDFDNTVAIHPTAAE GSHR_ECOLI 424 6 KMGATKADFDNTVAIHPTGSE GSHR_HAEIN 430 6 KLNAKISDFYNTIGVHPTSAE TYTR_TRYCR 446 6 KMGAKISDFYNTIGVHPTSAE TYTR_CRIFA 446 6 KFGLTVGDLRETMAPYLTMAE MERA_BACSR 590 6 RNRMTVQELADQLFPYLTMVE MERA_PSEAE 520 6 FINAL MOTIF SETS PNDRDTASEI1 Length of motif = 23 Motif number = 1 Pyridine nucleotide disulphide reductase-I motif I - 4 PCODE ST INT DVTVIGSGPGGYVAAIKAAQLGF DLDH_PIG 43 43 DVTVIGSGPGGYVAAIKAAQLGF DLDH_HUMAN 43 43 DVTVIGSGPGGYVAAIKAAQLGF Q14131 43 43 DVTVIGSGPGGYVAAIKAAQLGF DLDH_CANFA 43 43 DVTVIGSGPGGCVAAIKSAQLGF O08749 43 43 DVVVVGGGPGGYVAAIKAAQLGL DLDH_TRYBB 13 13 DLVVIGAGPGGYVAAIKAAQLGM O18480 32 32 DVVVIGGGPGGYVAAIKAAQLGL Q41219 38 38 DVVVIGGGPGGYVASIKAAQLGM P90599 13 13 DVVVIGGGPGGYVASIKAAQLGM P90598 13 13 DVVVIGGGPGGYVASIKAAQLGM P90597 13 13 DVVVIGGGPGGYVAAIKAAQLGL O81413 38 38 ELLVIGAGPGGYVAAIRAAQNGI DLDH_HALVO 10 10 DVVIIGGGPGGYVAAIKAAQLGF DLDH_PEA 39 39 DVVVIGAGPGGYVAAIKAAQLGL DLD2_PSEPU 5 5 DVVVIGAGPGGYVAAIRAAQLGL DLDH_PSEFL 5 5 DTIVIGAGPGGYVAAIRAAQLGQ Q59822 11 11 DVVIIGGGPGGYNAAIRAGQLGL DLD3_PSEPU 5 5 DVIIIGGGPGGYVCAIRCAQLGL P95596 5 5 DLCVIGGGPGGYVAAIRGAQLGL O00087 47 47 DVIVIGAGPGGYVAAIKSAQLGL DLDH_AZOVI 6 6 DVVIIGGGPAGYVAAIKAAQLGF DLDH_YEAST 28 28 DTLVIGAGPGGYVAAIRAAQLGQ DLD1_BACSU 11 11 ETLVVGAGPGGYVAAIRAAQLGQ DLD1_BACST 11 11 DYLVIGGGSGGLASARRAAELGA GSHR_HUMAN 22 22 DLFVIGAGSGGVRAARIAAGHGA GSHR_BURCE 7 7 QVVVIGSGGAAMAAALKAVEQGA MERA_ENTAG 100 100 QVVVIGSGGAAMAAALKAVEQGA O06510 100 100 HIAVIGSGGAAMAAALKAVEQGA MERA_SHIFL 99 99 DYIIIGSGGAAFSSAIEAVKYGA O69236 86 86 QVAVIGSGGAAMAAALKAVEQGA MERA_PSEAE 100 100 DCVVIGAGPGGYVAAITAAQAGL O84561 6 6 QVVVIGSGGAAMAAALKAVEQGA MERA_ACICA 100 100 NLVVIGGGPGGYVAAIRAAQLGA Q59299 117 117 DVLVIGAGPGGYIAAIRAGQLGL DLDH_ALCEU 6 6 HVAIIGTGGAAVAAALKAAENGA O08449 108 108 HIAVIGSGGAAMAAALKAVEQGA O54319 101 101 QVAVIGSGGAAMAAALKAVEQGA O66017 100 100 DLLIIGSGGAAFSAAIKANENGA MERA_STAAU 87 87 HIAIIGSGGAAMAAALKAVEQGA MERA_PSEFL 87 87 DLIVLGAGPGGYVGAIRAAQLGM Q60154 7 7 HIAIIGSGGAAMAAALKAVEQGA Q56447 87 87 HVAVIGSGGAAMAAALKVVEGGA O05610 98 98 DYIIIGSGGAAFSSAIEAVALNA O69256 171 171 QVVVLGAGPAGYSAAFRCADLGL DLDH_HAEIN 7 7 DLFVIGAGSGGVRAARFAAGFGA GSHR_PSEAE 6 6 DLIVIGAGSGGVRAARVAAAHGA O86924 7 7 DLFVIGAGSGGLAASKRAASYGA GSHR_ANASP 6 6 DYIAIGGGSGGIASLNRAASYGK GSHR_HAEIN 6 6 DYIVIGGGSGGIASANRAAMHGA Q60151 6 6 HIAVIGTGGAAMACALKAVERGA MERA_THIFE 86 86 DVVVLGGGPGGYSAAFAAADEGL Q51225 119 119 QVVVLGAGPAGYSAAFRCADLGL DLDH_ECOLI 7 7 DYIIIGSGGAAFSSAIEAVALNA O86216 171 171 DYIAIGGGSGGIASINRAAMYGQ GSHR_ECOLI 6 6 DVVILGGGTGGYVAAIRAAQLGL DLD2_BACSU 6 6 HVAIIGTGSGAFACAIKAAEGGA MERA_SHEPU 96 96 QVVVLGSGPAGYSAAFRCADLGL O50286 8 8 DLFTIGAGSGGVRASRFATSFGA GSHC_ARATH 89 89 DVVVLGAGPGGYVAAIRAAQLGL Q50068 5 5 DLIIIGGGSGGLAAAKEAAKYDK TRXB_BOVIN 14 14 DLIIIGGGSGGLAAAKEAAQYGK Q99475 66 66 DLIIIGGGSGGLAAAKEAAQYGK TRXB_HUMAN 14 14 DYLVIGGGSGGIASARRAAEFKV O01412 11 11 DLIIIGGGSGGLAAAKEAAKFDK O89049 14 14 DYIIIGSGGAAFSSAIEAVALNA MERA_BACSR 171 171 EMLVLGAGPGGYSAAFRAADLGM Q59099 122 122 DLFIIGAGSGGVRAARFSSNFGA GSHR_PEA 26 26 DLAIIGSGAGAFAAAIAARNKGR MERA_STRLI 9 9 DLFVIGAGSGGVRAARFSANHGA GSHR_ARATH 27 27 DLVILGGGSGGYACAFRAAELGL Q54101 7 7 DLIVIGGGSGGMAAARRAARHNA Q94655 4 4 DLIVIGGGSGGMAAARRAARHNA O15770 4 4 TLLIIGGGPGGYVAAIRAGQLGI DLD1_PSEPU 8 8 DLVVIGAGSGGLEAAWNAATLYK TYTR_TRYCR 7 7 DLVIIGAGSGGLEAGWNAATLYK TYTR_TRYCO 6 6 DLVVIGAGSGGLEAGWNAATLYK TYTR_TRYBB 6 6 DLIIVGAGSGGYEAGLYAFRRGM O66945 4 4 DVAVIGSGPGGYEAALHAARHGM O50311 12 12 DVVVLGAGPGGYVAAIRAAQLGL O53747 5 5 DLFTIGAGSGGVRARRFAANYGA GSHC_SOYBN 68 68 DYVVIGGGPGGMASAKEAAAHGA Q25861 43 43 TLAIIGGGPAGYAAAVSAAQQGR O34324 2 2 DLFVIGAGSGGVRAARFSANNGA O04955 30 30 DLVVIGAGSGGLEAGWNAASLHK TYTR_CRIFA 6 6 DVLIIGGGPGGYVAAIRAGQLGL Q48419 6 6 DLIIIGAGPAGYVAAEYAGKHKL DLDH_MYCPN 4 4 DLIILGAGPAGYIAAEYAGKHKL DLDH_MYCGE 4 4 DYLVIGGGSGGVASARRAASYGA GSHR_YEAST 25 25 DLIVIGGGSGGLACAKEAVANGA P91884 13 13 DVCVVGAGIGGYVTAIKSAQLGL Q49111 165 165 DLVVIGAGTAGLVVAAGAAGLGI P73059 40 40 DLIVIGGGSGGLAAAKEASRLGK TRXB_CAEEL 32 32 DLIVLGGGPGGYVAAIRAAQLNL DLDH_ZYMMO 6 6 DIVVIGSGPGGQKAAIASAKLGK O07212 5 5 DLIVIGAGSGGLSCSKRAADLGA GSHR_CAEEL 22 22 DVVVLGSGPAGEGAAMNAAKAGR O05139 7 7 DVLVIGCGPGGFTAAMQASQAGL Q02733 19 19 QVLVIGAGPGGEDCARELAENGI P96104 513 513 RIVILGGGPAGYEAALVAATSHP O53355 4 4 DVVFIGSGHAAWHAALTLKHAGK O54279 5 5 DVVFIGSGHAAWHAALTLKHAGK O54274 5 5 PNDRDTASEI2 Length of motif = 16 Motif number = 2 Pyridine nucleotide disulphide reductase-I motif II - 4 PCODE ST INT LGGTCLNVGCIPSKAL DLDH_PIG 76 10 LGGTCLNVGCIPSKAL DLDH_HUMAN 76 10 LGGTCLNVGCIPSKAL Q14131 76 10 LGGTCLNVGCIPSKAL DLDH_CANFA 76 10 LGGTCLNVGCIPSKAL O08749 76 10 LGGTCLNVGCIPSKAL DLDH_TRYBB 46 10 LGGTCLNVGCIPSKAL O18480 65 10 LGGTCLNVGCIPSKAL Q41219 71 10 LGGTCLNVGCIPSKAL P90599 46 10 LGGTCLNVGCIPSKAL P90598 46 10 LGGTCLNVGCIPSKAL P90597 46 10 LGGTCLNVGCIPSKAL O81413 71 10 YGGTCLNYGCIPSKAL DLDH_HALVO 42 9 LGGTCLNVGCIPSKAL DLDH_PEA 72 10 LGGTCLNVGCIPSKAL DLD2_PSEPU 44 16 LGGTCLNVGCIPSKAL DLDH_PSEFL 44 16 LGGVCLNVGCIPSKAL Q59822 43 9 LGGTCLNVGCMPSKAL DLD3_PSEPU 38 10 LGGTCLNVGCIPSKAL P95596 38 10 LGGTCLNVGCIPSKAL O00087 80 10 LGGTCLNVGCIPSKAL DLDH_AZOVI 45 16 LGGTCLNVGCIPSKAL DLDH_YEAST 61 10 LGGVCLNVGCIPSKAL DLD1_BACSU 43 9 LGGVCLNVGCIPSKAL DLD1_BACST 43 9 LGGTCVNVGCVPKKVM GSHR_HUMAN 54 9 FGGTCVIRGCVPKKLL GSHR_BURCE 39 9 IGGTCVNVGCVPSKIM MERA_ENTAG 132 9 IGGTCVNVGCVPSKIM O06510 132 9 IGGTCVNVGCVPSKIM MERA_SHIFL 131 9 IGGTCVNIGCVPSKTL O69236 118 9 IGGTCVNVGCVPSKIM MERA_PSEAE 132 9 AGGTCLNRGCIPSKAL O84561 38 9 IGGTCVNVGCVPSKIM MERA_ACICA 132 9 LGGTCLNVGCIPTKVL Q59299 149 9 LGGTCLNVGCIPSKAL DLDH_ALCEU 47 18 IGGTCVNVGCVPSKIM O08449 140 9 IGGTCVNVGCVPSKIM O54319 133 9 IGGTCVNLGCVPSKIM O66017 132 9 VGGTCVNIGCVPSKTM MERA_STAAU 119 9 IGGTCVNIGCVPSKIM MERA_PSEFL 119 9 LGGVCLNEGCIPSKAL Q60154 40 10 IGGTCVNIGCVPSKIM Q56447 119 9 IGGTCVNVGCVPSKIM O05610 130 9 VGGTCVNVGCVPSKTL O69256 203 9 LGGVCLNVGCIPSKAL DLDH_HAEIN 40 10 LGGTCVNVGCVPKKLL GSHR_PSEAE 38 9 VGGTCVIRGCVPKKLL O86924 39 9 VGGTCVIRGCVPKKLM GSHR_ANASP 38 9 LGGTCVNVGCVPKKVM GSHR_HAEIN 38 9 VGGTCVNVGCVPKKVM Q60151 38 9 IGGTCVNIGCVPSKIM MERA_THIFE 118 9 LGGVCLNVGCIPSKAL Q51225 152 10 LGGVCLNVGCIPSKAL DLDH_ECOLI 40 10 VGGTCVNVGCVPSKTL O86216 203 9 LGGTCVNVGCVPKKVM GSHR_ECOLI 38 9 LGGTCLHKGCIPSKAL DLD2_BACSU 38 9 IGGCCVNVGCVPSKIL MERA_SHEPU 129 10 LGGVCLNVGCIPSKAL O50286 41 10 VGGTCVLRGCVPKKLL GSHC_ARATH 131 19 WGGICLNVGCIPSKVL Q50068 37 9 LGGTCVNVGCIPKKLM TRXB_BOVIN 55 18 LGGTCVNVGCIPKKLM Q99475 107 18 LGGTCVNVGCIPKKLM TRXB_HUMAN 55 18 LGGTCVNKGCVPKKIM O01412 43 9 LGGTCVNVGCIPKKLM O89049 55 18 VGGTCVNVGCVPSKTL MERA_BACSR 203 9 LGGVCLNVGCIPSKAL Q59099 155 10 VGGTCVIRGCVPKKIL GSHR_PEA 68 19 TGGTCVNVGCVPSKAL MERA_STRLI 41 9 VGGTCVIRGCVPKKIL GSHR_ARATH 69 19 LGGTCLHRGCIPTKAL Q54101 39 9 LGGTCVNVGCVPKKIM Q94655 36 9 LGGTCVNVGCVPKKIM O15770 36 9 LGGTCLNIGCIPSKAL DLD1_PSEPU 40 9 LGGTCVNVGCVPKKLM TYTR_TRYCR 49 19 LGGTCVNVGCVPKKLM TYTR_TRYCO 48 19 LGGTCVNVGCVPKKLM TYTR_TRYBB 48 19 VGGNCLNRGCIPSKYM O66945 38 11 LGGVCVNWGCIPTKAL O50311 44 9 WGGVCLNVGCIPSKAL O53747 37 9 VGGTCVIRGCVPKKLL GSHC_SOYBN 109 18 IGGTCVNVGCVPKKLM Q25861 84 18 LGGTCLNEGCIPTKSL O34324 34 9 VGGTCVIRGCVPKKIL O04955 72 19 LGGTCVNVGCVPKKLM TYTR_CRIFA 48 19 LGGICLNWGCIPTKAL Q48419 38 9 FGGVCLNVGCIPTKTL DLDH_MYCPN 36 9 FGGVCLNVGCIPTKTL DLDH_MYCGE 36 9 LGGTCVNVGCVPKKVM GSHR_YEAST 57 9 IGGTCVNVGCIPKKLM P91884 54 18 YGGVCLNVGCIPTKTL Q49111 197 9 MGGDCLNFGCIPSKAL P73059 74 11 LGGTCVNVGCIPKKLM TRXB_CAEEL 73 18 LGGICLNWGCIPTKSL DLDH_ZYMMO 38 9 LGGVCVNTGTIPSKTL O07212 38 10 IGGTCANVGCIPKKLM GSHR_CAEEL 63 18 VGGNCTHLGTIPSKAL O05139 40 10 LGGAYLVDGAVPSKTL Q02733 52 10 AGRECLWRGCIPSKAW P96104 545 9 IGGAAVLDDCVPSKTF O53355 39 12 IAGTCTNYGCNAKILL O54279 37 9 IAGTCTNYGCNAKILL O54274 37 9 PNDRDTASEI3 Length of motif = 10 Motif number = 3 Pyridine nucleotide disulphide reductase-I motif III - 4 PCODE ST INT ILIATGSEVT DLDH_PIG 179 87 ILIATGSEVT DLDH_HUMAN 179 87 ILIATGSEVT Q14131 179 87 ILIATGSEVT DLDH_CANFA 179 87 ILVATGSEVT O08749 179 87 TIIATGSEPT DLDH_TRYBB 149 87 ILIATGSEVT O18480 166 85 IIIATGSDVK Q41219 173 86 TIIATGSEPT P90599 149 87 TIIATGSEPT P90598 149 87 TIIATGSEPT P90597 149 87 IIIATGSDVK O81413 173 86 CIIATGSRVI DLDH_HALVO 144 86 IIIATGSDVK DLDH_PEA 174 86 VILASGSRPI DLD2_PSEPU 146 86 VIIASGSRPV DLDH_PSEFL 146 86 AIIATGSRPI Q59822 143 84 IVIATGSEPT DLD3_PSEPU 140 86 IVIATGSESS P95596 127 73 FIIATGSEVK O00087 183 87 VILASGSKPV DLDH_AZOVI 147 86 IIVATGSEVT DLDH_YEAST 170 93 AIIATGSRPI DLD1_BACSU 143 84 AIIATGSRPI DLD1_BACST 143 84 ILIATGGMPS GSHR_HUMAN 152 82 ILIATGARPV GSHR_BURCE 135 80 CLVATGASPA MERA_ENTAG 236 88 CLVATGASPA O06510 236 88 CLIATGASPA MERA_SHIFL 235 88 FLIATGASPA O69236 215 81 CLVATGASPA MERA_PSEAE 236 88 IILATGSEPR O84561 137 83 CLVATGASPA MERA_ACICA 236 88 AIIATGSMPF Q59299 251 86 VIIATGSKAR DLDH_ALCEU 148 85 CLIATGASAA O08449 244 88 CLIATGASPA O54319 237 88 CLVATGASPA O66017 236 88 FLIATGASPA MERA_STAAU 216 81 CLVATGASPA MERA_PSEFL 223 88 VLLATGGKVA Q60154 145 89 CLVATGASPV Q56447 223 88 CLVATGASAA O05610 234 88 FLIATGASST O69256 300 81 AIIAAGSRPV DLDH_HAEIN 141 85 ILVATGGWPQ GSHR_PSEAE 134 80 ILVATGARPL O86924 136 81 ILIAVGGRPI GSHR_ANASP 134 80 ILIATGGRPY GSHR_HAEIN 140 86 ILIATGGHPL Q60151 135 81 CLVATGASPA MERA_THIFE 222 88 CIIAAGSRVT Q51225 263 95 AIIAAGSRPI DLDH_ECOLI 140 84 FLIATGASST O86216 300 81 ILIATGGRPS GSHR_ECOLI 135 81 VIIATGSRPR DLD2_BACSU 147 93 ILIATGSTPT MERA_SHEPU 232 87 AIVAAGSRPI O50286 141 84 ILIAVGGRPF GSHC_ARATH 228 81 VIIATGSKTR Q50068 141 88 FLIATGERPR TRXB_BOVIN 157 86 FLIATGERPR Q99475 209 86 FLIATGERPR TRXB_HUMAN 157 86 ILIAVGGYPK O01412 139 80 FLIATGERPR O89049 157 86 FLIATGASST MERA_BACSR 300 81 AIIAAGSQAV Q59099 263 92 ILIATGSRAQ GSHR_PEA 170 86 YLIATGSAPT MERA_STRLI 144 87 ILIATGSRAQ GSHR_ARATH 171 86 VVLATGSYSK Q54101 135 80 ILIAVGNKPV Q94655 145 93 ILIAVGNKPV O15770 145 93 LLLATGSSSV DLD1_PSEPU 139 83 ILLASGSWPH TYTR_TRYCR 157 92 IIIATGSWPQ TYTR_TRYCO 156 92 ILLATGSWPQ TYTR_TRYBB 156 92 ILVATGSSPT O66945 136 82 IIVATGAQPR O50311 145 85 AIIATGSSTR O53747 138 85 ILVAVGGRPF GSHC_SOYBN 206 81 ILIATGCRPH Q25861 188 88 VLIASGSEPI O34324 136 86 ILIRTGSRAQ O04955 174 86 ILLATGSWPQ TYTR_CRIFA 156 92 VILATGARPR Q48419 139 85 IVVATGSRPR DLDH_MYCPN 133 81 IIVATGSRPR DLDH_MYCGE 133 81 ILVATGGKAI GSHR_YEAST 164 91 VVIAVGGRPR P91884 158 88 LVIASGSTPN Q49111 297 84 AIIATGAKAV P73059 172 82 FLISTGLRPK TRXB_CAEEL 176 87 IIIATGARAR DLDH_ZYMMO 139 85 IIIATGTRPA O07212 141 87 VVISTGLRPK GSHR_CAEEL 169 90 IIIATGSRPY O05139 141 85 IVVATGSAVI Q02733 156 88 CVIATGAPAF P96104 643 82 VLVATGASPR O53355 148 93 IVIATGQHSN O54279 132 79 IVIATGQHSN O54274 132 79 PNDRDTASEI4 Length of motif = 26 Motif number = 4 Pyridine nucleotide disulphide reductase-I motif IV - 4 PCODE ST INT KMVVIGAGVIGVELGSVWQRLGADVT DLDH_PIG 215 26 KMVVIGAGVIGVELGSVWQRLGADVT DLDH_HUMAN 215 26 KMVVIGAGVIGVELGSVWQRLGADVT Q14131 215 26 KMVVIGAGVIGVELGSVWQRLGADVT DLDH_CANFA 215 26 KLVVIGAGVIGVELGSVWQRLGADVT O08749 215 26 KMVVIGGGVIGLELGSVWARLGSDVT DLDH_TRYBB 185 26 KMLVIGAGVIGLELGSVYQRLGADVT O18480 202 26 KLVVIGAGYIGLEMGSVWGRIGSEVT Q41219 209 26 TMVVIGGGVIGLELGSVWARLGAEVT P90599 185 26 TMVVIGGGVIGLELGSVWARLGAEVT P90598 185 26 TMVVIGGGVIGLELGSVWARLGAKVT P90597 185 26 RLIVIGAGYIGLEMGSVWGRLGSEIT O81413 209 26 RLVVVGGGYIGMELSTTFAKLGADVT DLDH_HALVO 180 26 KLVVIGAGYIGLEMGSVWGRIGSEVT DLDH_PEA 210 26 RLGVIGAGVIGLELGSVWARLGAEVT DLD2_PSEPU 182 26 KLGVIGAGVIGLELGSVWARLGAEVT DLDH_PSEFL 182 26 KLVVVGGGYIGSELGTAFANFGSEVT Q59822 178 25 HLVVIGAGVIGLELGSVWRRLGSQVT DLD3_PSEPU 176 26 SMVVIGAGVIGLELGSVYARLGAEVT P95596 163 26 KMTVLGGGIIGLEMGSVWSRLGAEVT O00087 220 27 KLGVIGAGVIGLELGSVWARLGAEVT DLDH_AZOVI 183 26 RLTIIGGGIIGLEMGSVYSRLGSKVT DLDH_YEAST 206 26 KLVVIGGGYIGTELGTAYANFGTELV DLD1_BACSU 178 25 SLVVIGGGYIGIELGTAYANFGTKVT DLD1_BACST 178 25 RSVIVGAGYIAVEMAGILSALGSKTS GSHR_HUMAN 189 27 RIAIIGGGYIACEFAGIFNGLGRHVV GSHR_BURCE 169 24 RLAVIGSSVVALELAQAFARLGSKVT MERA_ENTAG 272 26 RLAVIGSSVVALELAQAFARLGSKVT O06510 272 26 RLAVIGSSVVALELAQAFARLGAKVT MERA_SHIFL 271 26 RLVVIGSGYIGMELGQLFHNLGSEVT O69236 251 26 RLAVIGSSVVALELAQAFARLGSKVT MERA_PSEAE 272 26 KMAIIGGGVIGCEFASLFHTLGSEVS O84561 175 28 RLAVIGSSVVALELAQAFARLGSQVT MERA_ACICA 272 26 SIAIIGGGVIGVEFASIFNSLGCKVS Q59299 287 26 KLGVIGAGVIGLELGSVWRRLGSDVT DLDH_ALCEU 184 26 RLAVIGASVVALELAQAFARLGSEVT O08449 280 26 RLAVIGSSVVALELAQAFVRLGSQVT O54319 273 26 PLAVIGSSVVALELAQAFARLGSKVT O66017 272 26 RLAVIGSGYIAAELGQMFHNLGTEVT MERA_STAAU 252 26 RLAVIGSSVVALELAQAFARLGSQVT MERA_PSEFL 259 26 HLMIIGAGYIGLELGSVWLRLGSKVT Q60154 181 26 RLAVIGSSVVALELAQAFARLGSQVT Q56447 259 26 RLAVIGASVVAVELAQAFARLGSEVT O05610 270 26 RLTVIGSGYIGMELGQLFHNLGSEVT O69256 336 26 KLLIMGGGIIGLEMGTVYNALGSEVE DLDH_HAEIN 177 26 RVLVVGGGYIAVEFASIFNGLGAETT GSHR_PSEAE 168 24 RIAIVGGGYIANEFAGIFNELGSAVT O86924 170 24 HIAIIGSGYIGTEFAGIMRGLGSQVT GSHR_ANASP 168 24 RAAVIGAGYIAVELSGVLNSLGVETH GSHR_HAEIN 174 24 RTAVIGAGYIAVEVAGVLNALGSDTH Q60151 169 24 RLAVIGSSVVALELAQAFARLGSHVT MERA_THIFE 258 26 KLLIIGGGIIGLEMGTVYSTLGSRLD Q51225 298 25 RLLVMGGGIIGLEMGTVYHALGSQID DLDH_ECOLI 176 26 RLTVIGSGYIGMELGQLFHNLGSEVT O86216 336 26 RVAVVGAGYIAVELAGVINGLGAKTH GSHR_ECOLI 169 24 SIIIVGGGVIGIEWASMLHDFGVKVT DLD2_BACSU 183 26 HLVVIGSSVVALEIAQAYRRLGSEVT MERA_SHEPU 268 26 KLLIMGGGIIGLEMGTVYHSLGSKVE O50286 177 26 KIAIVGGGYIALEFAGIFNGLNCEVH GSHC_ARATH 262 24 SIVIVGAGAIGIEFGYVLKNYGVDVT Q50068 176 25 KTLVVGASYVALECAGFLAGIGLDVT TRXB_BOVIN 192 25 KTLVVGASYVALECAGFLAGIGLDVT Q99475 244 25 KTLVVGASYVALECAGFLAGIGLGVT TRXB_HUMAN 192 25 RTVVVGGGYIAIELSSMLSALGSDVH O01412 173 24 KTLVVGASYVALECAGFLAGIGLDVT O89049 192 25 RLTVIGSGYIGMELGQLFHNLGSEVT MERA_BACSR 336 26 KMLVIGGGIIGLEMATVYSTLGADID Q59099 298 25 RAVILGGGYIAVEFASIWRGMGSSVN GSHR_PEA 204 24 HLLILGGGYVGLEQAQLFARLGSRVT MERA_STRLI 180 26 RAIVLGGGYIAVEFASIWRGMGATVD GSHR_ARATH 205 24 KVVVLGGGVIGVEFASVWRSFGAEVT Q54101 170 25 KIGIVGSGYIAVELINVIKRLGIDSY Q94655 178 23 KIGIVGSGYIAVELINVIKRLGIDSY O15770 178 23 HLVVVGGGYIGLELGIAYRKLGAQVS DLD1_PSEPU 174 25 RVLTVGGGFISVEFAGIFNAYKPKDG TYTR_TRYCR 191 24 RVLTVGGGFISVEFAGIFNAYKPVGG TYTR_TRYCO 190 24 RVLTVGGGFISVEFAGIFNAYKPPGG TYTR_TRYBB 190 24 KVLIVGGGAVGVEFAYIFRKYGSEVV O66945 172 26 SMIVVGGGAIGVEMAWFYAKAGAKVT O50311 181 26 SIIIAGAGAIGMEFGYVLKNYGVDVT O53747 173 25 KIAIVGGGYIALEFAGIFNGLKSEVH GSHC_SOYBN 240 24 KTLVVGASYVALECSGFLNSLGYDVT Q25861 224 26 SLVIVGGGVIGCEYAGLFARLGSQVT O34324 172 26 RAIVLGGGYIAVEFASIWRGMGATVD O04955 208 24 RALCVGGGYISIEFAGIFNAYKARGG TYTR_CRIFA 190 24 SLLIIGSGAIGVEFASLYNDLGCKVT Q48419 175 26 KLVVVGGGVIGIEFAFLYASLGSEVT DLDH_MYCPN 173 30 KFVVVGGGVIGVEFAFLFASLGSEVT DLDH_MYCGE 173 30 KVVVVGAGYIGIELAGVFHGLGSETH GSHR_YEAST 199 25 KTLVVGAGYIGLECAGFLKGLGYDAT P91884 193 25 TLVVIGGGVIGIEFSCLFASLGTKVT Q49111 337 30 RLGVIGGGPIGCELAQAFQRLGAQVT P73059 208 26 KTLCVGASYVSLECAGFLHGFGFDVT TRXB_CAEEL 211 25 KLLVIGSGAIGIEFASLYADFGAEVS DLDH_ZYMMO 175 26 SMVVVGAGVIGIEYASMFAALGTKVT O07212 177 26 KTLIVGGGYVALECAGFLSAFNQNVE GSHR_CAEEL 203 24 KLIIYGAGVIGCEYASIFSGLGVLVE O05139 177 26 RFTIMGGGTIGLEIACIFNNLGSRVT Q02733 192 26 RLCVIGAGAIGMEMAQMFHDFGAEVR P96104 683 30 HLIVVGSGVTGAEFVDAYTELGVPVT O53355 184 26 NITFIGAGIISIEFASIAIKSGAEVH O54279 166 24 SITFIGAGIISIEFSSIAIKSGAEVH O54274 166 24 PNDRDTASEI5 Length of motif = 15 Motif number = 5 Pyridine nucleotide disulphide reductase-I motif V - 4 PCODE ST INT DVLLVCIGRRPFTQN DLDH_PIG 307 66 DVLLVCIGRRPFTKN DLDH_HUMAN 307 66 DVLLVCIGRRPFTKN Q14131 307 66 DVLLVCIGRRPFTQN DLDH_CANFA 307 66 DVLLVCIGRRPFTQN O08749 307 66 DALLVSVGRRPYTAG DLDH_TRYBB 277 66 DVVLISIGRRPYTKD O18480 295 67 DVVLVSAGRTPFTSG Q41219 299 64 EALLVSVGRRPFTGG P90599 275 64 EALLVSVGRRPFTGG P90598 275 64 EALLVSVGRRPFTGG P90597 275 64 DVVLVSAGRTPFTAE O81413 299 64 DKVLVAVGRSPVTDT DLDH_HALVO 269 63 DVVLVSAGRTPFTSG DLDH_PEA 300 64 DKLIVAVGRRPVTTD DLD2_PSEPU 270 62 DKLIVAVGRRPVTTD DLDH_PSEFL 270 62 DYVLVTVGRRPNTDE Q59822 266 62 DYVLVAIGRRPYTKG DLD3_PSEPU 266 64 EVVLVATGRKPFTKG P95596 253 64 DVLLVAIGRVPYTEG O00087 310 64 DKLIVAVGRRPVTTD DLDH_AZOVI 271 62 EVLLVAVGRRPYIAG DLDH_YEAST 298 66 DYVLITVGRRPNTDE DLD1_BACSU 267 63 DYVLVTVGRRPNTDE DLD1_BACST 266 62 DCLLWAIGRVPNTKD GSHR_HUMAN 283 68 DAVMAATGRLPNTWG GSHR_BURCE 254 59 DKLLVATGRTPNTRS MERA_ENTAG 355 57 DKLLVATGRTPNTRS O06510 355 57 DKLLVATGRAPNTRK MERA_SHIFL 358 61 DQLLVATGRTPNTAT O69236 339 62 DKLLVATGRTPNTRS MERA_PSEAE 355 57 DYVLVSIGRRLNTEN O84561 259 58 DQLLVATGRAPNTRS MERA_ACICA 355 57 EKVLIAVGRRSNIEG Q59299 375 62 DRLIVSVGRVPNTDN DLDH_ALCEU 273 63 DQLLVATGRTPNTAS O08449 363 57 DKLLVATGRAPNTCS O54319 356 57 DKLLVATGRTPNTRS O66017 355 57 DQVLVATGRKPNTET MERA_STAAU 340 62 DKLLVATGRAPNTRS MERA_PSEFL 342 57 DKVLMSIGRKPNTDG Q60154 269 62 DKLLVATGRAPNTRS Q56447 342 57 DQLLVATGRTPNTQG O05610 353 57 EQLLIATGRKPNTES O69256 424 62 DAVLVAIGRVPNGKL DLDH_HAEIN 264 61 DCVFYATGRRPMLDD GSHR_PSEAE 254 60 DCLMFAIGRVPNSSD O86924 256 60 DVFLVATGRVPNVDG GSHR_ANASP 255 61 DCVIWAAGRVPTTDK GSHR_HAEIN 260 60 DCLIWAVGRAANTSG Q60151 255 60 DKLLVATGRAPNTRR MERA_THIFE 341 57 DAVLVAAGRAPNGKL Q51225 387 63 DAVLVAIGRVPNGKN DLDH_ECOLI 264 62 EQLLIATGRKPNTES O86216 424 62 DCLIWAIGREPANDN GSHR_ECOLI 255 60 EKMLVSIGRQANIEG DLD2_BACSU 273 64 DRLLVSTGRHANTCQ MERA_SHEPU 351 57 DAVLVAIGRVPNGKL O50286 265 62 SHVMFATGRKPNTKN GSHC_ARATH 348 60 DKVLQAIGFAPNVDG Q50068 264 62 NTVLLAIGRDACTRK TRXB_BOVIN 285 67 NTVMLAIGRDACTRK Q99475 337 67 NTVMLAIGRDACTRK TRXB_HUMAN 285 67 NCLIWAVGRLPETSD O01412 259 60 NTVLLAVGRDSCTRT O89049 285 67 EQLLIATGRKPIQTS MERA_BACSR 424 62 DLVLVSVGRSPNGKR Q59099 387 63 DVVLFATGRSPNSKR GSHR_PEA 289 59 SHLLIATGRRSVTNG MERA_STRLI 267 61 DVVLFATGRSPNTKR GSHR_ARATH 290 59 DLLLVAVGRGPNTAA Q54101 255 59 DHVIYCVGRSPDTEN Q94655 265 61 DHVIYCVGRSPDTEN O15770 265 61 DRVLVAVGRRPRTKG DLD1_PSEPU 259 59 DLVMMAIGRSPRTKD TYTR_TRYCR 280 63 DVVMMAIGRLPRTGY TYTR_TRYCO 279 63 DVVMMAIGRIPRTND TYTR_TRYBB 279 63 DFILLGVGRKPNTKG O66945 259 61 SCMLVAVGVTGVIDG O50311 270 63 EKVLQAIGFAPNVEG O53747 261 62 SHIMFATGRRPNTQN GSHC_SOYBN 326 60 DTVLYAIGRKGDIDG Q25861 308 58 DYVLVAIGRKPRLDG O34324 258 60 DVVLFATGRIPNTKR O04955 293 59 DVVMLAIGRVPRSQT TYTR_CRIFA 279 63 ERVLLAVGVQPNIED Q48419 263 62 DRILVSIGRIPNTEC DLDH_MYCPN 257 58 DKILVSIGRIANTEC DLDH_MYCGE 257 58 DELIWTIGRKSHLGM GSHR_YEAST 287 62 DTVLWAIGRKGLVDD P91884 283 64 EYVLESVGRKTSLTG Q49111 422 59 DEILVGAGRAPNVEE P73059 296 62 NTILMAIGREAVTDD TRXB_CAEEL 310 73 SHAIVAIGVVANVEN DLDH_ZYMMO 264 63 ETVMYSAGRQGQTDH O07212 262 59 DTVIWAAGRVPNLKS GSHR_CAEEL 288 59 DALLWCNGRTGNTDK O05139 262 59 DVLMVSIGRRPLLKG Q02733 283 65 DLLLVATGKRPDTSG P96104 773 64 SHALMTIGSVPNTSG O53355 269 59 EYVLDATGRKPNVQN O54279 251 59 DYVLDATGRKPNVQN O54274 251 59 PNDRDTASEI6 Length of motif = 8 Motif number = 6 Pyridine nucleotide disulphide reductase-I motif VI - 4 PCODE ST INT IYAIGDVV DLDH_PIG 350 28 IYAIGDVV DLDH_HUMAN 350 28 IYAIGDVV Q14131 350 28 IYAIGDVV DLDH_CANFA 350 28 IYAIGDVV O08749 350 28 VYAIGDVV DLDH_TRYBB 320 28 IYAIGDVI O18480 338 28 VYAIGDVI Q41219 342 28 VYAIGDVV P90599 318 28 VYAIGDVV P90598 318 28 VYAIGDVV P90597 318 28 VYAIGDVI O81413 342 28 IYAVGDVV DLDH_HALVO 312 28 VYAIGDVI DLDH_PEA 343 28 VYAIGDVV DLD2_PSEPU 313 28 VFAIGDVV DLDH_PSEFL 313 28 IYAIGDIV Q59822 309 28 VWVIGDVT DLD3_PSEPU 308 27 LYAIGDAI P95596 296 28 IRVIGDAT O00087 353 28 VYAIGDVV DLDH_AZOVI 314 28 IKVVGDVT DLDH_YEAST 341 28 IYAIGDII DLD1_BACSU 310 28 IFAIGDIV DLD1_BACST 309 28 IYAVGDVC GSHR_HUMAN 326 28 IYAVGDVT GSHR_BURCE 297 28 IYAAGDCT MERA_ENTAG 398 28 IYAAGDCT O06510 398 28 IYAAGDCT MERA_SHIFL 401 28 IYAAGDVT O69236 382 28 IYAAGDCT MERA_PSEAE 398 28 IYAIGDIT O84561 302 28 IYAAGDCT MERA_ACICA 398 28 IYAIGDCT Q59299 417 27 LWAIGDVV DLDH_ALCEU 316 28 IYAAGDCT O08449 406 28 IYAAGDCT O54319 399 28 IYAAGDCT O66017 398 28 IYAAGDVT MERA_STAAU 383 28 IYAAGDCT MERA_PSEFL 385 28 IYAIGDLI Q60154 312 28 IYAAGDCT Q56447 385 28 IYAAGDCT O05610 396 28 IYAAGDVT O69256 467 28 IYAIGDIV DLDH_HAEIN 307 28 ILALGDVI GSHR_PSEAE 297 28 IFAVGDVT O86924 299 28 IYAVGDVT GSHR_ANASP 308 38 IYAVGDII GSHR_HAEIN 303 28 IYALGDVT Q60151 298 28 IYAAGDCT MERA_THIFE 384 28 IYAIGDIV Q51225 430 28 IFAIGDIV DLDH_ECOLI 307 28 IYSAGDVT O86216 467 28 IYAVGDNT GSHR_ECOLI 298 28 IYAIGDVI DLD2_BACSU 315 27 IYAAGDCC MERA_SHEPU 394 28 IFAIGDIV O50286 308 28 IWAVGDVT GSHC_ARATH 391 28 IYAIGDVT Q50068 307 28 IYAIGDIL TRXB_BOVIN 329 29 IYAIGDIL Q99475 381 29 IYAIGDIL TRXB_HUMAN 329 29 IYAVGDCC O01412 302 28 IYAIGDIL O89049 329 29 IYSAGDVT MERA_BACSR 467 28 IFAIGDIV Q59099 430 28 IWAVGDVT GSHR_PEA 332 28 IWAAGDVT MERA_STRLI 310 28 IWAVGDAT GSHR_ARATH 333 28 VYAVGDIV Q54101 297 27 IYAVGDCC Q94655 307 27 IYAVGDCC O15770 307 27 VWAIGDVA DLD1_PSEPU 301 27 IYAIGDVT TYTR_TRYCR 322 27 IYAIGDVT TYTR_TRYCO 322 28 IYAIGDIT TYTR_TRYBB 322 28 IYACGDIT O66945 302 28 IYAIGDVR O50311 312 27 IYAIGDVN O53747 304 28 IWAVGDVT GSHC_SOYBN 369 28 IFAVGDVA Q25861 352 29 IYACGDAI O34324 300 27 IWAVGDAT O04955 336 28 IYAIGDVT TYTR_CRIFA 322 28 LYAIGDVA Q48419 305 27 IYIVGDAN DLDH_MYCPN 298 26 IYLIGDVN DLDH_MYCGE 298 26 IYSLGDVV GSHR_YEAST 329 27 IFAVGDII P91884 325 27 VYAIGDVV Q49111 463 26 IYAAGDIC P73059 338 27 VYAIGDVL TRXB_CAEEL 353 28 VWAIGDVA DLDH_ZYMMO 306 27 IYAVGDVI O07212 305 28 VYAVGDIV GSHR_CAEEL 332 29 IYGAGDVI O05139 305 28 IKPIGDVT Q02733 327 29 IYAVGDVI P96104 816 28 IYAAGDCT O53355 312 28 IYASGDVL O54279 293 27 IYASGDVL O54274 293 27 PNDRDTASEI7 Length of motif = 22 Motif number = 7 Pyridine nucleotide disulphide reductase-I motif VII - 4 PCODE ST INT DYNCVPSVIYTHPEVAWVGKSE DLDH_PIG 385 27 DYNCVPSVIYTHPEVAWVGKSE DLDH_HUMAN 385 27 DYNCVPSVIYTHPEVAWVGKSE Q14131 385 27 DYNCVPSVIYTHPEVAWVGKSE DLDH_CANFA 385 27 DYNCVPSVIYTHPEVAWVGKSE O08749 385 27 NYDVIPGVIYTMPEVASVGKTE DLDH_TRYBB 356 28 NYDAIPSVIYTSPEVGWVRKTE O18480 373 27 DYDKVPGVVYTNPEVASVGKTE Q41219 377 27 NYGVIPAVIYTMPEVASVGKSE P90599 354 28 NYGVIPAVIYTMPEVASVGKSE P90598 354 28 NYGVIPAVIYTMPEVASVGKSE P90597 354 28 DYDKVPGVVYTMPEVASVGKTE O81413 377 27 DSQAVPAAVFTDPEIGTVGMTE DLDH_HALVO 348 28 DYDKVPGVVYTNPEVASVGKTE DLDH_PEA 378 27 NYDLIPSVIYTHPEIAWVGKTE DLD2_PSEPU 348 27 NYDLIPSVIYTHPEIAWVGKTE DLDH_PSEFL 348 27 DYIGMPAVCFTEPELATVGYSE Q59822 344 27 NYNLIPGVIYTRPELATVGKTE DLD3_PSEPU 343 27 NYDVIPGVIYTTPEVAAVGKTE P95596 331 27 NYNCIPAVMYTHPEVAWVGITE O00087 388 27 NYDLIPAVIYTHPEIAGVGKTE DLDH_AZOVI 349 27 NYNNIPSVMYSHPEVAWVGKTE DLDH_YEAST 376 27 DYLGIPAVVFSEPELASVGYTE DLD1_BACSU 345 27 DYVAIPAVVFSDPECASVGYFE DLD1_BACST 344 27 DYNNIPTVVFSHPPIGTVGLTE GSHR_HUMAN 363 29 EHENVPFAVFSQPQAASVGLSE GSHR_BURCE 333 28 DLTAMPAVVFTDPQVATVGYSE MERA_ENTAG 433 27 DLTAMPAVVFTDPQVATVGYSE O06510 433 27 NLTAMPAVVFTDPQVATVGYSE MERA_SHIFL 436 27 NLEVVPGVTFTAPAIATVGLTE O69236 418 28 DLTAMPAVVFTDPQVATVGYSE MERA_PSEAE 433 27 DYSAVPSVIFTFPEVASVGLSP O84561 337 27 DLTAMPAVVFTDPQVATVGYSE MERA_ACICA 433 27 DYKTVPACVYTKPELASVGLTE Q59299 452 27 DYNCVPWVIYTFPEIAWVGKTE DLDH_ALCEU 351 27 DLDAMPAVVFTDPQVATVGYSE O08449 441 27 NLTAMPAVVFTDPQVATVGYSE O54319 434 27 NLTAMPAVVFTDPQVATVGYSE O66017 433 27 DLRFVPGVTFTNPSIATVGLTE MERA_STAAU 419 28 NLTAMPAVVFTDPQVATVGYSE MERA_PSEFL 420 27 HYGTIPGVCYTWPEVASVGKTE Q60154 347 27 NLTAMPAVVFTDPQVATVGYSE Q56447 420 27 NLDVMPAVVFTDPQVATVGYSE O05610 431 27 NLEVVPGVTFTSPSIATVGLTE O69256 503 28 DPKVIPSIAYTEPEVAWVGKTE DLDH_HAEIN 342 27 DYKLIPTAVFSLPNIGTVGLTE GSHR_PSEAE 334 29 DYRHVPSAVFSHPPIAFVGLTE O86924 335 28 SHETIATAVFSNPQASTLGLTE GSHR_ANASP 344 28 DYSLVPTVVFSHPPIGTVGLTE GSHR_HAEIN 341 30 DYTDVATVVFSHPAIGAIGLTE Q60151 335 29 DLTAMPAVVFTDPQVATVGYSA MERA_THIFE 419 27 DARVIPGVAYTSPEVAWVGETE Q51225 465 27 DPKVIPSIAYTEPEVAWVGLTE DLDH_ECOLI 342 27 NLEVVPGVTFTSPSIATVGLTE O86216 503 28 DYSNIPTVVFSHPPIGTVGLTE GSHR_ECOLI 335 29 DPTLVPKCIYSSPEAASVGLTE DLD2_BACSU 351 28 DLSTMPAVIFTDPQVATVGLTE MERA_SHEPU 429 27 DPKVIPSIAYTEPEVAWVGKTE O50286 343 27 DYRAVPCAVFSQPPIGTVGLTE GSHC_ARATH 427 28 DYRMMPRATFCQPNVASFGLTE Q50068 344 29 DYENVPTTVFTPLEYGSCGLSE TRXB_BOVIN 366 29 DYENVPTTVFTPLEYGACGLSE Q99475 418 29 DYENVPTTVFTPLEYGACGLSE TRXB_HUMAN 366 29 DYENIPTVVFSHPPLGTVGLTE O01412 339 29 DYDNVPTTVFTPLEYGCCGLSE O89049 366 29 NLEVVPGVTFTSPSIATVGLTE MERA_BACSR 503 28 DAKQIPSVAFTDPEVAWAGLTE Q59099 465 27 DYNDIPYAVFCIPPLSVVGLSE GSHR_PEA 368 28 DYTALPKVTFTSPAIASVGLTE MERA_STRLI 346 28 EYSNVACAVFCIPPLAVVGLSE GSHR_ARATH 369 28 DESGIPRVTYSHPEVASVGLTE Q54101 333 28 NYKLIPTVIFSHPPIGTIGLSE Q94655 377 62 NYKLIPTVIFSHPPIGTIGLSE O15770 377 62 EPAAIAAVCFTDPEVVVVGKTP DLD1_PSEPU 336 27 DHTRVASAVFSIPPIGTCGLIE TYTR_TRYCR 358 28 DHTRVASAVFSIPPIGTCGLTE TYTR_TRYCO 358 28 DHTRVASAVFSIPPIGTCGLIE TYTR_TRYBB 358 28 NERIIPKIIYSALEVASVGLTE O66945 338 28 SEPLIPRCVYAQPSVASVGLTE O50311 348 28 DHRMLPRATFCQPNVASFGLTE O53747 341 29 DYRAVPSAVFSQPPIGQVGLTE GSHC_SOYBN 405 28 DYSYIPTSIYTPIEYGACGYSE Q25861 389 29 NEKHVPRCIYTSPEIACIGMTE O34324 335 27 DYTNVACAVFCIPPLAVVGLSE O04955 372 28 DHTKVACAVFSIPPMGVCGYVE TYTR_CRIFA 358 28 DRDYVPGCTYARPQVASLGLTE Q48419 342 29 QKLTCPSCIYTNPEVASVGYTE DLDH_MYCPN 335 29 EKNKCPACIYTNPEVAFVGYSE DLDH_MYCGE 335 29 DYENVPSVIFSHPEAGSIGISE GSHR_YEAST 368 31 DYTDVATTVFSPLEYACVGMAE P91884 362 29 NYDKVPSCIYTHPEVSMIGKTE Q49111 505 34 SSLTMPWVTYTDPEIAHVGLNE P73059 378 32 EYDQIPTTVFTPLEYGCCGLSE TRXB_CAEEL 390 29 NTQNIPGCTYARPQVASVGLTE DLDH_ZYMMO 343 29 ITELQPIGIYSIPEVSYVGATE O07212 340 27 RFDGVATTVFTPLELSTVGLTE GSHR_CAEEL 369 29 YVNDVPTGIYTIPEISSIGKNE O05139 340 27 NCGFPPNVLYCQPQIGWVGYTE Q02733 364 29 EAAKDCGVTFTRPQCAFVGLSL P96104 851 27 RLRTVAATVFTRPEIAAVGVPQ O53355 348 28 QYPAIPSVLYSLPRLSQIGVTV O54279 331 30 QYPVIPSVLYSLPRLSQIGVTV O54274 331 30 PNDRDTASEI8 Length of motif = 16 Motif number = 8 Pyridine nucleotide disulphide reductase-I motif VIII - 4 PCODE ST INT VLGAHIIGPGAGEMIN DLDH_PIG 450 43 VLGAHILGPGAGEMVN DLDH_HUMAN 450 43 VLGAHILGPGAGEMVN Q14131 450 43 VLGAHILGPGAGEMVN DLDH_CANFA 450 43 VLGAHILGPGAGEMVN O08749 450 43 ILGVHIVCSAAGELIA DLDH_TRYBB 421 43 ILGTHIIGPGGGELIN O18480 438 43 ILGVHIMAPNAGELIH Q41219 442 43 ILGVHIVCTTAGELIG P90599 419 43 ILGVHIVCTTAGELIG P90598 419 43 ILGVHIVCTTAGELIG P90597 419 43 ILGVHIMAPNAGELIH O81413 442 43 VLGAQIVGPEASELIA DLDH_HALVO 413 43 ILGVHIMAPNAGELIH DLDH_PEA 443 43 VLGVHVIGPSAAELVQ DLD2_PSEPU 413 43 VLGVHVIGPSAAELVQ DLDH_PSEFL 413 43 LIGAQVVGTGASDIIS Q59822 409 43 VLGVHLVGPSVSEMIG DLD3_PSEPU 408 43 ILGAHIIGPSAGDMIH P95596 396 43 LLGVHMIGPMAGELIG O00087 453 43 VLGVHVIGPSAAELVQ DLDH_AZOVI 414 43 ILGAHIIGPNAGEMIA DLDH_YEAST 441 43 VIGAQIAGASASDMIS DLD1_BACSU 410 43 IIGAQIIGPNASDMIA DLD1_BACST 409 43 VVGIHMQGLGCDEMLQ GSHR_HUMAN 430 45 VVGAHIVGADAAEIIQ GSHR_BURCE 398 43 LIGVQAVAPEAGELIQ MERA_ENTAG 498 43 LIGVQAVAPEAGELIQ O06510 498 43 LIGVQAVAPEAGELIQ MERA_SHIFL 501 43 VLGAHVVAENAGDVIY O69236 483 43 LIGVQAVAPEAGELIQ MERA_PSEAE 498 43 ILGAYVIGPHASSLIS O84561 402 43 LIGVQAVAPEAGELIQ MERA_ACICA 498 43 ILGVHILGPRATDLIT Q59299 517 43 ILGVHIVAANASDLIA DLDH_ALCEU 416 43 ILGVQAVTPEAGEIIQ O08449 506 43 LLGAQVVAPEGGEVIQ O54319 499 43 LIGVQAVAPEAGELIQ O66017 498 43 LIGAHIVSENAGDVIY MERA_STAAU 484 43 LIGVQAVAPEAGELIQ MERA_PSEFL 485 43 VLGVHIFGPRASDMIA Q60154 412 43 LIGVQAVAPEAGELIQ Q56447 485 43 LLGVQAVAPEAGELIQ O05610 496 43 VLGAHIVTENAGDVIY O69256 568 43 VLGGAIVGSNGGELLG DLDH_HAEIN 407 43 VLGCHMVGAEAGEILQ GSHR_PSEAE 399 43 ILGLHMIGPDAPEILQ O86924 400 43 VLGAHMVGENAAEIIQ GSHR_ANASP 410 44 VVGLHGIGFGVDEMIQ GSHR_HAEIN 408 45 IIGLHGIGYGVDEMIQ Q60151 402 45 LIGVQVVAPEAGELIQ MERA_THIFE 482 41 IIGGGIVGPNGGDMIG Q51225 530 43 VIGGAIVGTNGGELLG DLDH_ECOLI 407 43 VLGAHVVAENAGDVIY O86216 568 43 IVGIHGIGFGMDEMLQ GSHR_ECOLI 402 45 ILGVHMIGPHVTDMIS DLD2_BACSU 416 43 LIGAQILAHEGGELIQ MERA_SHEPU 494 43 VIGGAIVGTNGGELLG O50286 408 43 VLGVHMCGEDSPEIIQ GSHC_ARATH 492 43 LLGGHMIGHNVSELLP Q50068 409 43 VVGFHVLGPNAGEVTQ TRXB_BOVIN 435 47 VVGFHVLGPNAGEVTQ Q99475 487 47 VVGFHVLGPNAGEVTQ TRXB_HUMAN 435 47 VVGLHMLGEGCDEMLQ O01412 406 45 VVGFHVLGPNAGEVTQ O89049 435 47 VLGAHVVAENAGDVIY MERA_BACSR 568 43 VIGGGIVGTHAGDLIS Q59099 530 43 VLGASMCGPDAPEIVQ GSHR_PEA 434 44 LLAAHVLAEGAGDVIT MERA_STRLI 411 43 VIGASMCGPDAAEIMQ GSHR_ARATH 435 44 VVGLHMVGDRVGELIG Q54101 396 41 IKGLHIIGLNADEIVQ Q94655 448 49 IKGLHIIGLNADEIVQ O15770 448 49 ILGWQAVGVAVSELST DLD1_PSEPU 401 43 VLGVHLLGDNAPEIIQ TYTR_TRYCR 424 44 VVGVHLLGDSSPEIIQ TYTR_TRYCO 424 44 VLGVHLLGDGAPEIIQ TYTR_TRYBB 424 44 ILGCHIVGPHAGELIH O66945 403 43 MLGGHLIGHDAVELIG O50311 413 43 LLGGHLVGHDVAELLP O53747 406 43 VLGLHMCGEDAPEIVQ GSHC_SOYBN 470 43 VIGFHYVGPNAGEVTQ Q25861 472 61 IVGVSMIGPDVTELIG O34324 400 43 VIGASMCGPDAAEIMQ O04955 438 44 VLGVHMLGDSSPEIIQ TYTR_CRIFA 424 44 LLGAHMVGAQVTEQIQ Q48419 407 43 ILGCCIIAATASDMIA DLDH_MYCPN 400 43 ILGGCIIASTASDIIA DLDH_MYCGE 400 43 VVGLHIVGDSSAEILQ GSHR_YEAST 435 45 VLGLHYLGPVAGEVIQ P91884 431 47 ILGAHIIGNRATEMIS Q49111 570 43 ILGATIVASHAGEMIS P73059 443 43 VVGFHILTPNAGEVTQ TRXB_CAEEL 460 48 LLGAHMVGAEVTEMIH DLDH_ZYMMO 408 43 LLGVHIFGTSATEMVH O07212 405 43 ILGLHFVGPNAAEVIQ GSHR_CAEEL 439 48 VLGVHCFGYQASEIVH O05139 405 43 ILGVHMINDDANELLS Q02733 435 49 IVGVHFLADHADTLVG P96104 916 43 VIGGVVVAPIASELIL O53355 413 43 LVGAEIYADDAANLIN O54279 394 41 LVGAEIYADDAANLIN O54274 394 41 PNDRDTASEI9 Length of motif = 21 Motif number = 9 Pyridine nucleotide disulphide reductase-I motif IX - 4 PCODE ST INT EYGASCEDIARVCHAHPTLSE DLDH_PIG 472 6 EYGASCEDIARVCHAHPTLSE DLDH_HUMAN 472 6 EYGASCEDIARVCHAHPTLSE Q14131 472 6 EYGASCEDIARVCHAHPTLSE DLDH_CANFA 472 6 EYGASCEDIARVCHAHPTLSE O08749 472 6 EYGASSEDVGRTCHAHPTMSE DLDH_TRYBB 443 6 EYGAAAEDVARVCHAHPTCAE O18480 460 6 QYDASSEDIARVCHAHPTMSE Q41219 464 6 EYGASSEDVGRTCHAHPTMSE P90599 441 6 EYGASSEDVGRTCHAHPTMSE P90598 441 6 EYGASSEDVGRTCHAHPTMSE P90597 441 6 QYDASSEDIARVCHAHPTMSE O81413 464 6 EMGATLEDVASTIHTHPTLAE DLDH_HALVO 435 6 QYDASSEDIARVCHANPTMSE DLDH_PEA 465 6 EFGTSAEDLGMMVFSHPTLSE DLD2_PSEPU 435 6 EFGTSAEDLGMMVFSHPTLSE DLDH_PSEFL 435 6 EAGMNAEDIALTIHAHPTLGE Q59822 431 6 EFSASAEDIALTCHPHPTRSE DLD3_PSEPU 430 6 EFGASAQDLALTCHAHPTYSE P95596 418 6 EYGASAEDVARVCHAHPTLSE O00087 475 6 EFGTSAEDLGMMVFAHPALSE DLDH_AZOVI 436 6 EYGASAEDVARVCHAHPTLSE DLDH_YEAST 463 6 EGGMTAEDIAMTIHAHPTLGE DLD1_BACSU 432 6 EAGMTAEDIALTIHAHPTLGE DLD1_BACST 431 6 KMGATKADFDNTVAIHPTSSE GSHR_HUMAN 452 6 KARATKADFDATLGVHPTLAE GSHR_BURCE 420 6 RNRMTVQELADQLFPYLTMVE MERA_ENTAG 520 6 RNRMTVQELADQLFPYLTMVE O06510 520 6 RNRMTVQELADQLFPYLTMVE MERA_SHIFL 523 6 KFGLTVDDIRETLAPYLTMAE O69236 505 6 RNRMTVQELADQLFPYLTMVE MERA_PSEAE 520 6 RNELTLPCIYETIHAHPTLAE O84561 424 6 RNRMTVQELADQLFPYLTMVE MERA_ACICA 520 6 RLEATLEEIITTVHAHPTVGE Q59299 539 6 EFKAASEDIGRVCHPHPSMSE DLDH_ALCEU 438 6 RARMTVQDLANQLFPYLTMVQ O08449 528 6 RARMTVQELADQLFPYLTMVE O54319 521 6 RNRMTVQELADQLFPYLTMVE O66017 520 6 QFGLTIEDLTDSFAPYLTMAE MERA_STAAU 506 6 RNRMTVQELADQLFPYLTMVE MERA_PSEFL 507 6 SYGGTAHDIGAMFHGHPTLSE Q60154 434 6 RNRMTVQELADQLFPYLTMVE Q56447 507 6 RNRMTVQELADQLFPYLTMVE O05610 518 6 KFGLTVEDLRGTMAPYLTMAE O69256 590 6 EMGCDAEDIALTIHAHPTLHE DLDH_HAEIN 429 6 KAGATKQAFDETIGIHPTAAE GSHR_PSEAE 421 6 KAGLSKAAFDETIALHPTMAE O86924 422 6 KMGATKKDFDATVGIHPSSAE GSHR_ANASP 432 6 KMGATKADFDNTVAIHPTGSE GSHR_HAEIN 430 6 KMGATKADFDNTVAIHPTGSE Q60151 424 6 RNRMTVQELADQLFPYLTMVE MERA_THIFE 504 6 EMGCDAADIGKTIHPHPTLGE Q51225 552 6 EMGCDAEDIALTIHAHPTLHE DLDH_ECOLI 429 6 KFGLTVGDLRETMAPYLTMAE O86216 590 6 KMGATKKDFDNTVAIHPTAAE GSHR_ECOLI 424 6 VLDATPWEVGQTIHPHPTLSE DLD2_BACSU 438 6 RNRMTVTELADQLFPYLTMVE MERA_SHEPU 516 6 EMGCDAEDIALTIHAHPTLHE O50286 430 6 KAGLTKADFDATVGVHPTAAE GSHC_ARATH 514 6 KWDLTATELVRNVHTHPTLSE Q50068 431 6 KCGLTKDQLDSTIGIHPVCAE TRXB_BOVIN 457 6 KCGLTKKQLDSTIGIHPVCAE Q99475 509 6 KCGLTKKQLDSTIGIHPVCAE TRXB_HUMAN 457 6 KMGATKKDFDNTVAIHPTGAE O01412 428 6 KCGLTKQQLDSTIGIHPVCAE O89049 456 5 KFGLTVGDLRETMAPYLTMAE MERA_BACSR 590 6 EMGADAVDIGKTIHPHPTLGE Q59099 552 6 KCGATKAQFDSTVGIHPSSAE GSHR_PEA 456 6 TAGLTVDQLARTWHPYLTMAE MERA_STRLI 433 6 KCGATKAQFDSTVGIHPSSAE GSHR_ARATH 457 6 NWEALPEDVAPLVHAHPTQTE Q54101 418 6 KMNATKKDFDETIPIHPTAAE Q94655 470 6 KMNATKKDFDETIPIHPTAAE O15770 470 6 EMGACLEDVAGTIHAHPTLGE DLD1_PSEPU 423 6 KLNAKISDFYNTIGVHPTSAE TYTR_TRYCR 446 6 KLNAKISDFYNTIGVHPTSAE TYTR_TRYCO 446 6 RLNAKISDFYNTIGVHPTSAE TYTR_TRYBB 446 6 KDGKTVEFASKTMYSHPSLSE O66945 425 6 RYGVTAEGLVGTVHAHPTLSE O50311 435 6 RWDLTASELARNVHTHPTMSE O53747 428 6 KARLTKADFDATVGIHPSAAE GSHC_SOYBN 492 6 RLKVKKKDFDNCIGIHPTDAE Q25861 494 6 NGEMTADMAEHFIAAHPTLSE O34324 422 6 KCGATKAQFDSTVGIHPSSAE O04955 460 6 KMGAKISDFYNTIGVHPTSAE TYTR_CRIFA 446 6 HLEATDESLLSMIFAHPTLSE Q48419 429 6 GAGLTVFDIANSISPHPTINE DLDH_MYCPN 422 6 ENNLTVFDIANSISPHPTMNE DLDH_MYCGE 422 6 KMGATKADFDNCVAIHPTSAE GSHR_YEAST 457 6 KSGLTMKILLNTVGIHPTTAE P91884 453 6 ECEGTITEIANTIHPHPTMSE Q49111 592 6 VNKIGLSKLAGVIHPYPTQAE P73059 465 6 KLAAKKADFDRLIGIHPTVAE TRXB_CAEEL 482 6 TLETTEAEIMETIFPHPTLSE DLDH_ZYMMO 430 6 GCGGSVEYLVDAVFNYPTFSE O07212 427 6 RVGISMSDLQNTIAIHPCSSE GSHR_CAEEL 461 6 GEQNTLKYFVNTTFNYPTMAE O05139 430 9 SLGLTAHDVCKVPFPHPSLSE Q02733 457 6 SAGLTLEQVAGAIHPHPTQTE P96104 938 6 QNRITVNELAQTLAVYPSLSG O53355 435 6 NQKLTAKDLNQLIFAFPGSSS O54279 416 6 NQKLTAKDLNQLIFAFPRIIK O54274 416 6

User query: Display/Full Code "PNDRDTASEI"