WORKLIST ENTRIES (1):
NTKRECEPTOR2 View alignment Neurotrophic tyrosine kinase receptor type 2 signature
Type of fingerprint: COMPOUND with 4 elements
Links:
PRINTS; PR00109 TYRKINASE
PRINTS; PR01939 NTKRECEPTOR; PR01940 NTKRECEPTOR1; PR01942 NTKRECEPTOR3
PDB; 1HCF 3Dinfo; 1WWB 3Dinfo
SCOP; 1HCF; 1WWB
CATH; 1HCF; 1WWB
MIM; 600456
Creation date 03-APR-2008
1. BOTHWELL, M.
Functional interactions of neurotrophins and neurotrophin receptors.
ANNU.REV.NEUROSCI. 18 223-253 (1995).
2. HUANG, E. AND REICHARDT, L.
Neurotrophins: roles in neuronal development and function.
ANNU.REV.NEUROSCI. 24 677-736 (2001).
3. LEI, L. AND PARADA, L.
Transcriptional regulation of Trk family neurotrophin receptors.
CELL.MOL.LIFE SCI. 64 522-532 (2007).
4. RICO, B., XU, B. AND REICHARDT, L.
TrkB receptor signaling is required for establishment of GABAergic synapses
in the cerebellum.
NAT.NEUROSCI. 5 225-233 (2002).
5. YAMADA, K. AND NABESHIMA, T.
Brain-derived neurotrophic factor/TrkB signaling in memory processes.
J.PHARMACOL.SCI. 91 267-270 (2003).
Neurotrophins are a family of secreted proteins that regulate development,
maintenance and function of vertebrate nervous systems. They act via two
different classes of receptor: p75NTR (a member of the TNF receptor
superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also
known as tropomyosin-related kinases (Trks) [1].
NTRKs are multi-domain, transmembrane proteins - in addition to their
cytoplasmic kinase domains, members of the family possess a number of
extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand
binding induces them to dimerise, resulting in activation of their
cytoplasmic tyrosine kinase domains. The activated receptors couple to a
variety of intracellular signalling cascades, including the Ras,
phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP)
kinase, and phospholipase C (PLC)-gamma pathways [2].
NTRK2 (also termed TrkB) is a high-affinity receptor for brain-derived
neurotrophic factor (BDNF) and neurotrophin (NT-4). It is broadly expressed
in the nervous system, and is also found in some non-neural tissues [3].
The receptor is involved in synaptogenesis and neuronal development [4]. It
plays a crucial role in learning and memory [5].
NTKRECEPTOR2 is a 4-element fingerprint that provides a signature for
neurotrophic tyrosine kinase receptor type 2. The fingerprint was derived
from an initial alignment of 2 sequences: the motifs were drawn from
conserved regions spanning the N-terminal extracellular domain, focusing on
those sections that characterise NTRK2 but distinguish it from other members
of the NTRK family - motif 1 lies in the signal sequence, and motifs 3 and 4
each encompass short beta strands. Two iterations on SPTR55_38f were
required to reach convergence, at which point a true set comprising 10
sequences was identified. A single partial match was also found,
Q95K65_MACFA, a translated macaque cDNA that fails to match motifs 3 and 4.
SUMMARY INFORMATION
10 codes involving 4 elements
0 codes involving 3 elements
1 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
4| 10 10 10 10
3| 0 0 0 0
2| 1 1 0 0
--+---------------------
| 1 2 3 4
True positives..
NTRK2_HUMAN Q8WXJ7_HUMAN Q8WXJ5_HUMAN Q5VWE5_HUMAN
Q548C2_HUMAN Q0VCN4_BOVIN NTRK2_MOUSE Q3UHE3_MOUSE
NTRK2_RAT NTRK2_CHICK
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q95K65_MACFA
PROTEIN TITLES
NTRK2_HUMAN BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
Q8WXJ7_HUMAN Tyrosine-protein kinase receptor (EC 2.7.10.1) - Homo sapien
Q8WXJ5_HUMAN Neurotrophin receptor tyrosine kinase type 2 truncated isofo
Q5VWE5_HUMAN Neurotrophic tyrosine kinase, receptor, type 2 (Neurotrophic
Q548C2_HUMAN Neurotrophic tyrosine kinase receptor type 2 - Homo sapiens
Q0VCN4_BOVIN Neurotrophic tyrosine kinase, receptor, type 2 - Bos taurus
NTRK2_MOUSE BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
Q3UHE3_MOUSE CDNA, RIKEN full-length enriched library, clone:M5C1042H21 p
NTRK2_RAT BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
NTRK2_CHICK BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (N
Q95K65_MACFA Putative uncharacterized protein - Macaca fascicularis (Crab
SCAN HISTORY
SPTR55_38f 2 200 NSINGLE
INITIAL MOTIF SETS
NTKRECEPTOR21 Length of motif = 14 Motif number = 1
Neurotrophic tyrosine kinase receptor type 2 motif I - 1
PCODE ST INT
WGFCWLVVGFWRAA NTRK2_HUMAN 16 16
WGLCCLVLGCWRGA NTRK2_CHICK 16 16
NTKRECEPTOR22 Length of motif = 11 Motif number = 2
Neurotrophic tyrosine kinase receptor type 2 motif II - 1
PCODE ST INT
RIWCSDPSPGI NTRK2_HUMAN 42 12
RIWCSEPVPGI NTRK2_CHICK 42 12
NTKRECEPTOR23 Length of motif = 15 Motif number = 3
Neurotrophic tyrosine kinase receptor type 2 motif III - 1
PCODE ST INT
FAPTITFLESPTSDH NTRK2_HUMAN 285 232
FAPNITFIESPTPDH NTRK2_CHICK 284 231
NTKRECEPTOR24 Length of motif = 14 Motif number = 4
Neurotrophic tyrosine kinase receptor type 2 motif IV - 1
PCODE ST INT
ICTKIHVTNHTEYH NTRK2_HUMAN 330 30
ICTKIHVINQSEYH NTRK2_CHICK 329 30
FINAL MOTIF SETS
NTKRECEPTOR21 Length of motif = 14 Motif number = 1
Neurotrophic tyrosine kinase receptor type 2 motif I - 2
PCODE ST INT
WGFCWLVVGFWRAA NTRK2_HUMAN 16 16
WGFCWLVVGFWRAA Q8WXJ7_HUMAN 16 16
WGFCWLVVGFWRAA Q8WXJ5_HUMAN 16 16
WGFCWLVVGFWRAA Q5VWE5_HUMAN 16 16
WGFCWLVVGFWRAA Q548C2_HUMAN 16 16
WGFCWLIVGFWRAA Q0VCN4_BOVIN 16 16
WGLCLLVLGFWRAS NTRK2_MOUSE 16 16
WGLCLLVLGFWRAS Q3UHE3_MOUSE 16 16
WGLCLLVLGFWRAS NTRK2_RAT 16 16
WGLCCLVLGCWRGA NTRK2_CHICK 16 16
NTKRECEPTOR22 Length of motif = 11 Motif number = 2
Neurotrophic tyrosine kinase receptor type 2 motif II - 2
PCODE ST INT
RIWCSDPSPGI NTRK2_HUMAN 42 12
RIWCSDPSPGI Q8WXJ7_HUMAN 42 12
RIWCSDPSPGI Q8WXJ5_HUMAN 42 12
RIWCSDPSPGI Q5VWE5_HUMAN 42 12
RIWCSDPSPGI Q548C2_HUMAN 42 12
RIWCGDPSPGI Q0VCN4_BOVIN 42 12
RIWCTEPSPGI NTRK2_MOUSE 42 12
RIWCTEPSPGI Q3UHE3_MOUSE 42 12
RIWCTEPSPGI NTRK2_RAT 42 12
RIWCSEPVPGI NTRK2_CHICK 42 12
NTKRECEPTOR23 Length of motif = 15 Motif number = 3
Neurotrophic tyrosine kinase receptor type 2 motif III - 2
PCODE ST INT
FAPTITFLESPTSDH NTRK2_HUMAN 285 232
FAPTITFLESPTSDH Q8WXJ7_HUMAN 285 232
FAPTITFLESPTSDH Q8WXJ5_HUMAN 285 232
FAPTITFLESPTSDH Q5VWE5_HUMAN 285 232
FAPTITFLESPTSDH Q548C2_HUMAN 285 232
FAPTITFLESPTSDH Q0VCN4_BOVIN 285 232
FAPTITFLESPTSDH NTRK2_MOUSE 285 232
FAPTITFLESPTSDH Q3UHE3_MOUSE 285 232
FAPTITFLESPTSDH NTRK2_RAT 285 232
FAPNITFIESPTPDH NTRK2_CHICK 284 231
NTKRECEPTOR24 Length of motif = 14 Motif number = 4
Neurotrophic tyrosine kinase receptor type 2 motif IV - 2
PCODE ST INT
ICTKIHVTNHTEYH NTRK2_HUMAN 330 30
ICTKIHVTNHTEYH Q8WXJ7_HUMAN 330 30
ICTKIHVTNHTEYH Q8WXJ5_HUMAN 330 30
ICTKIHVTNHTEYH Q5VWE5_HUMAN 330 30
ICTKIHVTNHTEYH Q548C2_HUMAN 330 30
ICTKIHVTNHTEYH Q0VCN4_BOVIN 330 30
ICTKIHVTNHTEYH NTRK2_MOUSE 330 30
ICTKIHVTNHTEYH Q3UHE3_MOUSE 330 30
ICTKIHVTNHTEYH NTRK2_RAT 330 30
ICTKIHVINQSEYH NTRK2_CHICK 329 30
User query: Display/Full Code "NTKRECEPTOR2"