WORKLIST ENTRIES (1):
MAPKPHPHTASE View alignment View Structure MAP kinase phosphatase signature
Type of fingerprint: COMPOUND with 5 elements
Links:
PRINTS; PR00700 PRTYPHPHTASE
PDB; 1HZM 3Dinfo; 1VHR 3Dinfo
SCOP; 1HZM; 1VHR
CATH; 1HZM; 1VHR
Creation date 18-JUL-2002
1. SUN, H., CHARLES, C.H., LAU, L.F. AND TONKS, N.K.
MKP-1 (3CH134), an immediate-early gene-product is a dual specificity
phosphatase that dephosphorylates MAP kinase in-vivo.
CELL 75(3) 487-493 (1993).
2. MUDA, M., THEODOSIOU, A., RODRIGUES, N., BOSCHERT, U., CAMPS, M.,
GILLIERON, C., DAVIES, K., ASHWORTH, A. AND ARKINSTALL, S.
The dual specificity phosphatases M3/6 and MKP-3 are highly selective for
inactivation of distinct mitogen activated protein kinases.
J.BIOL.CHEM. 271(44) 27205-27208 (1996).
3. DIXON, J.E. AND SAPER, M.A.
Crystal structure of the dual specificity protein phosphatase VHR.
SCIENCE 272 1328-1331 (1996).
The dual specificity phosphatases, also known as MAP Kinase Phosphatases
(MKP), constitute a class of phosphatases that reverse the activation of MAP
(mitogen activated protein) kinases by dephosphorylating critical tyrosine
and threonine residues [1]. This regulation is mediated via interaction of a
Kinase Interaction Motif (KIM) with the common docking domain of the kinase
- this motif is shared with a number of other protein families that interact
with MAP kinases: these include kinases (MEKs), phosphatases (PTP-SL) and
transcription factors (Elk1). MKPs also share an active site motif with the
protein tyrosine phosphatases (PTPs). Different MKPs exhibit specificity
towards different members of the MAP kinase family [2].
The structure of the MPK catalytic domain is similar to that of the PTPs
[3] - the fold exhibits a complex mixed alpha-/beta-architecture. The
catalytic mechanism involves a general acid (Asp92 in 1VHR) and a catalytic
cysteine (130 in 1VHR), which acts as a nucleophile.
MAPKPHPHTASE is a 5-element fingerprint that provides a signature for the
MAP kinase phosphatases. The fingerprint was derived from an initial
alignment of 12 sequences: the motifs were drawn from conserved regions
spanning the full alignment length. Two iterations on SPTR40_20f were
required to reach convergence, at which point a true set comprising 30
sequences was identified. Several partial matches were also found, most of
which appear to be N- or C-terminal fragments.
SUMMARY INFORMATION
30 codes involving 5 elements
0 codes involving 4 elements
5 codes involving 3 elements
2 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
5| 30 30 30 30 30
4| 0 0 0 0 0
3| 0 0 5 5 5
2| 1 1 1 0 1
--+--------------------------
| 1 2 3 4 5
True positives..
Q64193 Q63683 DUS1_RAT DUS1_MOUSE
DUS1_HUMAN Q90W58 Q91790 DUS4_CHICK
DUS4_HUMAN DUS4_RAT DUS2_MOUSE DUS2_HUMAN
Q96N49 Q920R2 Q9AG16 Q9AG15
Q99MG6 Q99MG5 DUS9_HUMAN DUS6_HUMAN
DUS6_RAT Q99KC2 DUS5_RAT DUS5_HUMAN
DUS8_MOUSE Q91663 DUS8_HUMAN Q8UW48
Q9ESS0 Q9CZY9
Subfamily: Codes involving 3 elements
Subfamily True positives..
Q9NSW1 Q8WXV0 Q9H9Z5 Q95SV1
Q9VVW4
Subfamily: Codes involving 2 elements
Subfamily True positives..
Q96QS2 O44128
PROTEIN TITLES
Q64193 3CH134/CL100 PTPASE - Rattus sp.
Q63683 PROTEIN TYROSINE PHOSPHATASE - Rattus norvegicus (Rat).
DUS1_RAT Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1
DUS1_MOUSE Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1
DUS1_HUMAN Dual specificity protein phosphatase 1 (EC 3.1.3.48) (EC 3.1
Q90W58 MAP KINASE PHOSPHATASE XCL100(BETA) PROTEIN - Xenopus laevis
Q91790 DUAL SPECIFICITY PROTEIN PHOSPHATASE XCL100 (EC 3.1.3.48) (E
DUS4_CHICK Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1
DUS4_HUMAN Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1
DUS4_RAT Dual specificity protein phosphatase 4 (EC 3.1.3.48) (EC 3.1
DUS2_MOUSE Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1
DUS2_HUMAN Dual specificity protein phosphatase 2 (EC 3.1.3.48) (EC 3.1
Q96N49 CDNA FLJ31411 FIS, CLONE NT2NE2000214, MODERATELY SIMILAR TO
Q920R2 MAP KINASE PHOSPHATASE-7 - Mus musculus (Mouse).
Q9AG16 MAP KINASE PHOSPHATASE-M B1 ISOFORM - Mus musculus (Mouse).
Q9AG15 MAP KINASE PHOSPHATASE-M B2 ISOFORM - Mus musculus (Mouse).
Q99MG6 MAP KINASE PHOSPHATASE-M A1 ISOFORM - Mus musculus (Mouse).
Q99MG5 MAP KINASE PHOSPHATASE-M A2 ISOFORM - Mus musculus (Mouse).
DUS9_HUMAN Dual specificity protein phosphatase 9 (EC 3.1.3.48) (EC 3.1
DUS6_HUMAN Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1
DUS6_RAT Dual specificity protein phosphatase 6 (EC 3.1.3.48) (EC 3.1
Q99KC2 SIMILAR TO DUAL SPECIFICITY PHOSPHATASE 9 - Mus musculus (Mo
DUS5_RAT Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1
DUS5_HUMAN Dual specificity protein phosphatase 5 (EC 3.1.3.48) (EC 3.1
DUS8_MOUSE Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1
Q91663 DUAL SPECIFICITY PROTEIN PHOSPHATASE ? (EC 3.1.3.48) (EC 3.1
DUS8_HUMAN Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1
Q8UW48 DUAL SPECIFICITY PHOSPHATASE 6, ISOFORM A - Fugu rubripes (J
Q9ESS0 MAP KINASE PHOSPHATASE-5 - Mus musculus (Mouse).
Q9CZY9 2610306G15RIK PROTEIN - Mus musculus (Mouse).
Q9NSW1 HYPOTHETICAL 33.0 KDA PROTEIN - Homo sapiens (Human).
Q8WXV0 PHOSPHATASE - Homo sapiens (Human).
Q9H9Z5 CDNA FLJ12451 FIS, CLONE NT2RM1000377, HIGHLY SIMILAR TO HOM
Q95SV1 SD06439P - Drosophila melanogaster (Fruit fly).
Q9VVW4 CG14080 PROTEIN - Drosophila melanogaster (Fruit fly).
Q96QS2 TRUNCATED MAPK PHOSPHATASE 7 - Homo sapiens (Human).
O44128 C05B10.1 PROTEIN - Caenorhabditis elegans.
SCAN HISTORY
SPTR40_20f 2 75 NSINGLE
INITIAL MOTIF SETS
MAPKPHPHTASE1 Length of motif = 11 Motif number = 1
MAP kinase phosphatase motif I - 1
PCODE ST INT
LLLDCRPFLAF DUS2_HUMAN 28 28
VVLDCRPYLAF DUS5_RAT 24 24
LLLDCRPFLAH DUS4_HUMAN 46 46
LLLDCRPFLAH DUS4_RAT 47 47
LLLDCRSFFAF DUS1_HUMAN 25 25
LLLDCRSFFAF DUS1_MOUSE 25 25
LLLDCRSFFAF DUS1_RAT 25 25
LLLDCRSRELY DUS9_HUMAN 23 23
LILDCRSFFAF Q90W58 26 26
LLLDCRSFFAF Q64193 25 25
LLMDCRPQELY DUS6_HUMAN 35 35
LLMDCRPQELY DUS6_RAT 35 35
MAPKPHPHTASE2 Length of motif = 13 Motif number = 2
MAP kinase phosphatase motif II - 1
PCODE ST INT
ALLRRRARGPPAA DUS2_HUMAN 53 14
VVLRRARGGAVSA DUS5_RAT 50 15
TIVRRRAKGSVSL DUS4_HUMAN 71 14
TIVRRRAKGSVSL DUS4_RAT 72 14
TIVRRRAKGAMGL DUS1_HUMAN 50 14
TIVRRRAKGAMGL DUS1_MOUSE 50 14
TIVRRRAKGAMGL DUS1_RAT 50 14
LLLRRLRRGSLSV DUS9_HUMAN 49 15
TIVKRRAKGSMGL Q90W58 51 14
TIVRRRAKGAMGL Q64193 50 14
IMLRRLQKGNLPV DUS6_HUMAN 61 15
IMLRRLQKGNLPV DUS6_RAT 61 15
MAPKPHPHTASE3 Length of motif = 11 Motif number = 3
MAP kinase phosphatase motif III - 1
PCODE ST INT
ITAVLNVSASC DUS2_HUMAN 199 133
ITALLNVSRRT DUS5_RAT 205 142
ITALLNVSSDC DUS4_HUMAN 222 138
ITALLNVSSDC DUS4_RAT 223 138
ITALINVSANC DUS1_HUMAN 200 137
ITALINVSANC DUS1_MOUSE 200 137
ITALINVSANC DUS1_RAT 200 137
IRYILNVTPNL DUS9_HUMAN 230 168
ITALINVSANC Q90W58 202 138
ITALINVSANC Q64193 200 137
IKYILNVTPNL DUS6_HUMAN 233 159
IKYILNVTPNL DUS6_RAT 233 159
MAPKPHPHTASE4 Length of motif = 10 Motif number = 4
MAP kinase phosphatase motif IV - 1
PCODE ST INT
YKSIPVEDNQ DUS2_HUMAN 219 9
YKWIPVEDSH DUS5_RAT 225 9
YKCIPVEDNH DUS4_HUMAN 242 9
YKCIPVEDNH DUS4_RAT 243 9
YKSIPVEDNH DUS1_HUMAN 220 9
YKSIPVEDNH DUS1_MOUSE 220 9
YKSIPVEDNH DUS1_RAT 220 9
YKQIPISDHW DUS9_HUMAN 252 11
YKSIPVEDSH Q90W58 222 9
YKSIPVEDNH Q64193 220 9
YKQIPISDHW DUS6_HUMAN 255 11
YKQIPISDHW DUS6_RAT 255 11
MAPKPHPHTASE5 Length of motif = 13 Motif number = 5
MAP kinase phosphatase motif V - 1
PCODE ST INT
WFQEAIGFIDWVK DUS2_HUMAN 235 6
HFQEAIDFIDCVR DUS5_RAT 241 6
WFMEAIEYIDAVK DUS4_HUMAN 258 6
WFMEAIEYIDAVK DUS4_RAT 259 6
WFNEAIDFIDSIK DUS1_HUMAN 236 6
WFNEAIDFIDSIK DUS1_MOUSE 236 6
WFNEAIDFIDSIK DUS1_RAT 236 6
FFPEAIEFIDEAL DUS9_HUMAN 268 6
WFNEAIDFIDSIK Q90W58 238 6
WFNEAIDFIDSIK Q64193 236 6
FFPEAISFIDEAR DUS6_HUMAN 271 6
FFPEAISFIDEAR DUS6_RAT 271 6
FINAL MOTIF SETS
MAPKPHPHTASE1 Length of motif = 11 Motif number = 1
MAP kinase phosphatase motif I - 2
PCODE ST INT
LLLDCRSFFAF DUS1_HUMAN 25 25
LLLDCRSFFAF DUS1_MOUSE 25 25
LLLDCRSFFAF DUS1_RAT 25 25
LLLDCRSFFAF Q63683 25 25
LLLDCRSFFAF Q64193 25 25
LILDCRSFFAF Q90W58 26 26
LILDCRSFFSF Q91790 26 26
LLLDCRPFLAH DUS4_CHICK 30 30
LLLDCRPFLAH DUS4_HUMAN 46 46
LLLDCRPFLAH DUS4_RAT 47 47
LLLDCRPFLAF DUS2_MOUSE 32 32
LLLDCRPFLAF DUS2_HUMAN 28 28
LLIDSRPFVEY Q920R2 27 27
LLIDSRPFVEY Q96N49 27 27
LLIDSRPFVEY Q99MG5 27 27
LLIDSRPFVEY Q99MG6 27 27
LLIDSRPFVEY Q9AG15 27 27
LLIDSRPFVEY Q9AG16 27 27
LLLDCRSRELY DUS9_HUMAN 23 23
LLMDCRPQELY DUS6_HUMAN 35 35
LLMDCRPQELY DUS6_RAT 35 35
LLLDCRSRELY Q99KC2 23 23
VVLDCRPYLAF DUS5_HUMAN 24 24
VVLDCRPYLAF DUS5_RAT 24 24
LVIDSRSFVEY DUS8_MOUSE 28 28
LLMDCRAHELY Q91663 34 34
LVIDSRSFVEY DUS8_HUMAN 28 28
LVMDCRAQELY Q8UW48 36 36
VIIDCRPFMEY Q9CZY9 174 174
VIIDCRPFMEY Q9ESS0 174 174
MAPKPHPHTASE2 Length of motif = 13 Motif number = 2
MAP kinase phosphatase motif II - 2
PCODE ST INT
TIVRRRAKGAMGL DUS1_HUMAN 50 14
TIVRRRAKGAMGL DUS1_MOUSE 50 14
TIVRRRAKGAMGL DUS1_RAT 50 14
TIVRRRAKGAMGL Q63683 50 14
TIVRRRAKGAMGL Q64193 50 14
TIVKRRAKGSMGL Q90W58 51 14
TIVKRRAKGSMGL Q91790 51 14
TIVRRRAKGAVSL DUS4_CHICK 55 14
TIVRRRAKGSVSL DUS4_HUMAN 71 14
TIVRRRAKGSVSL DUS4_RAT 72 14
ALLRRRAPGTPAA DUS2_MOUSE 57 14
ALLRRRARGPPAA DUS2_HUMAN 53 14
KLMKRRLQQDKVL Q920R2 52 14
KLMKRRLQQDKVL Q96N49 52 14
KLMKRRLQQDRVL Q99MG5 52 14
KLMKRRLQQDRVL Q99MG6 52 14
KLMKRRLQQDRVL Q9AG15 52 14
KLMKRRLQQDRVL Q9AG16 52 14
LLLRRLRRGSLSV DUS9_HUMAN 49 15
IMLRRLQKGNLPV DUS6_HUMAN 61 15
IMLRRLQKGNLPV DUS6_RAT 61 15
LMLRRLRRGSMSV Q99KC2 49 15
VVLRRARGGAVSA DUS5_HUMAN 50 15
VVLRRARGGAVSA DUS5_RAT 50 15
KLVKRRLQQGKVT DUS8_MOUSE 53 14
IMLRRLKKGNLPI Q91663 60 15
KLVKRRLQQGKVT DUS8_HUMAN 53 14
LMLRRLKKGNLPV Q8UW48 62 15
KISRRRLQQGKIT Q9CZY9 200 15
KISRRRLQQGKIT Q9ESS0 200 15
MAPKPHPHTASE3 Length of motif = 11 Motif number = 3
MAP kinase phosphatase motif III - 2
PCODE ST INT
ITALINVSANC DUS1_HUMAN 200 137
ITALINVSANC DUS1_MOUSE 200 137
ITALINVSANC DUS1_RAT 200 137
ITALINVSANC Q63683 200 137
ITALINVSANC Q64193 200 137
ITALINVSANC Q90W58 202 138
ITALINVSANC Q91790 202 138
ITALLNVSSDC DUS4_CHICK 203 135
ITALLNVSSDC DUS4_HUMAN 222 138
ITALLNVSSDC DUS4_RAT 223 138
ITAVLNVSASC DUS2_MOUSE 203 133
ITAVLNVSASC DUS2_HUMAN 199 133
IGYVLNASNTC Q920R2 185 120
IGYVLNASNTC Q96N49 185 120
IGYVLNASNTC Q99MG5 130 65
IGYVLNASNTC Q99MG6 185 120
IGYVLNASNTC Q9AG15 130 65
IGYVLNASNTC Q9AG16 185 120
IRYILNVTPNL DUS9_HUMAN 230 168
IKYILNVTPNL DUS6_HUMAN 233 159
IKYILNVTPNL DUS6_RAT 233 159
IRYILNVTPNL Q99KC2 282 220
ITALLNVSRRT DUS5_HUMAN 205 142
ITALLNVSRRT DUS5_RAT 205 142
ISYVLNASNSC DUS8_MOUSE 187 121
IKYILNVTPNL Q91663 230 157
ISYVLNASNSC DUS8_HUMAN 187 121
IKYILNVTPNL Q8UW48 233 158
IGYVINVTTHL Q9CZY9 349 136
IGYVINVTTHL Q9ESS0 349 136
MAPKPHPHTASE4 Length of motif = 10 Motif number = 4
MAP kinase phosphatase motif IV - 2
PCODE ST INT
YKSIPVEDNH DUS1_HUMAN 220 9
YKSIPVEDNH DUS1_MOUSE 220 9
YKSIPVEDNH DUS1_RAT 220 9
YKSIPVEDNH Q63683 220 9
YKSIPVEDNH Q64193 220 9
YKSIPVEDSH Q90W58 222 9
YKSIPVEDSH Q91790 222 9
YKCIPVEDNH DUS4_CHICK 223 9
YKCIPVEDNH DUS4_HUMAN 242 9
YKCIPVEDNH DUS4_RAT 243 9
YKSIPVEDNQ DUS2_MOUSE 223 9
YKSIPVEDNQ DUS2_HUMAN 219 9
FLRVPVNDSF Q920R2 206 10
FLRVPVNDSF Q96N49 206 10
FLRVPVNDSF Q99MG5 151 10
FLRVPVNDSF Q99MG6 206 10
FLRVPVNDSF Q9AG15 151 10
FLRVPVNDSF Q9AG16 206 10
YKQIPISDHW DUS9_HUMAN 252 11
YKQIPISDHW DUS6_HUMAN 255 11
YKQIPISDHW DUS6_RAT 255 11
YKQIPISDHW Q99KC2 304 11
YKWIPVEDSH DUS5_HUMAN 225 9
YKWIPVEDSH DUS5_RAT 225 9
FMRIPINDNY DUS8_MOUSE 208 10
YKQIPISDHW Q91663 252 11
FMRVPINDNY DUS8_HUMAN 208 10
YKQIPISDHW Q8UW48 255 11
YKRLPATDSN Q9CZY9 371 11
YKRLPATDSN Q9ESS0 371 11
MAPKPHPHTASE5 Length of motif = 13 Motif number = 5
MAP kinase phosphatase motif V - 2
PCODE ST INT
WFNEAIDFIDSIK DUS1_HUMAN 236 6
WFNEAIDFIDSIK DUS1_MOUSE 236 6
WFNEAIDFIDSIK DUS1_RAT 236 6
WFNEAIDFIDSIK Q63683 236 6
WFNEAIDFIDSIK Q64193 236 6
WFNEAIDFIDSIK Q90W58 238 6
WFNEAIDFIDSVK Q91790 238 6
WFMEAIEYIDSVK DUS4_CHICK 239 6
WFMEAIEYIDAVK DUS4_HUMAN 258 6
WFMEAIEYIDAVK DUS4_RAT 259 6
WFQEAISFIDSVK DUS2_MOUSE 239 6
WFQEAIGFIDWVK DUS2_HUMAN 235 6
WLDKSVDFIEKAK Q920R2 222 6
WLDKSVDFIEKAK Q96N49 222 6
WLDKSVDFIEKAK Q99MG5 167 6
WLDKSVDFIEKAK Q99MG6 222 6
WLDKSVDFIEKAK Q9AG15 167 6
WLDKSVDFIEKAK Q9AG16 222 6
FFPEAIEFIDEAL DUS9_HUMAN 268 6
FFPEAISFIDEAR DUS6_HUMAN 271 6
FFPEAISFIDEAR DUS6_RAT 271 6
FFPEAIAFIDEAL Q99KC2 320 6
HFQEAIDFIDCVR DUS5_HUMAN 241 6
HFQEAIDFIDCVR DUS5_RAT 241 6
WLDKSIEFIDKAK DUS8_MOUSE 224 6
FFPEAISFIDEAR Q91663 268 6
WLDKSIEFIDKAK DUS8_HUMAN 224 6
FFPEAIGFIDEAR Q8UW48 271 6
YFEEAFEFIEEAH Q9CZY9 387 6
YFEEAFEFIEEAH Q9ESS0 387 6
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