WORKLIST ENTRIES (1):

INTRLKN1R1F View alignment View Structure     Interleukin-1 receptor type I family signature 
 Type of fingerprint: COMPOUND with 7  elements
Links:
   PRINTS; PR01536 INTRLKN1R12F; PR01538 INTRLEUKN1R1; PR01539 INTRLEUKN1R2
   PRINTS; PR01540 INTRLEUKN1BP
   PDB; 1ITB 3Dinfo; 1IRA 3Dinfo
   SCOP; 1ITB; 1IRA
   CATH; 1ITB; 1IRA

 Creation date 18-JUN-2001

   1. SIMS, J.E., MARCH, C.J., COSMAN, D., WIDMER, M.B., MACDONALD, H.R., 
   MCMAHAN, C.J., GRUBIN, C.E., WIGNALL, J.M., JACKSON, J.L., CALL, S.M.,
   FRIEND, D., ALPERT, A.R., GILLIS, S.R., URDAL, D.L. AND DOWER, S.K.
   cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin
   superfamily.
   SCIENCE 241 585-589 (1988).

   2. LIU, C., HART, R.P., LIU, X.J., CLEVENGER, W., MAKI, R.A. 
   AND DE SOUZA, E.B.
   Cloning and characterization of an alternatively processed human type II
   interleukin-1 receptor mRNA.
   J.BIOL.CHEM. 271 20965-20972 (1996). 

   3. MCMAHAN, C.J., SLACK, J.L., MOSLEY, B., COSMAN, D., LUPTON, S.D., 
   BRUNTON, L.L., GRUBIN, C.E., WIGNALL, J.M., JENKINS, N.A., BRANNAN, C.I.
   COPELAND, N.G., HUEBNER, K., CROCE, C.M., CANNIZZARRO, L.A., BENJAMIN, D.,
   DOWER, S.K., SPRIGGS, M.K. AND SIMS, J.E.
   A novel IL-1 receptor, cloned from B cells by mammalian expression, is 
   expressed in many cell types.
   EMBO J. 10 2821-2832 (1991). 

   Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are 
   cytokines that participate in the regulation of immune responses,
   inflammatory reactions, and hematopoiesis [1]. Two types of IL-1 receptor, 
   each with three extracellular immunoglobulin (Ig)-like domains, limited
   sequence similarity (28%) and different pharmacological characteristics
   have been cloned from mouse and human cell lines: these have been termed 
   type I and type II receptors [2]. The receptors both exist in transmembrane
   (TM) and soluble forms: the soluble IL-1 receptor is thought to be post-
   translationally derived from cleavage of the extracellular portion of the
   membrane receptors [2].
  
   Both IL-1 receptors appear to be well conserved in evolution, and map to the
   same chromosomal location [3]. The receptors can both bind all three forms 
   of IL-1 (IL-1 alpha, IL-1 beta and IL-1RA) [3]. The mature type I IL-1 
   receptor consists of (i) a ligand binding portion comprising three Ig-like
   domains; (ii) a single TM domain; and (iii) a large cytoplasmic domain of 
   ~215 amino acids. This domain is shared by a number of other proteins, 
   including the rat FIT-1M precursor, the murine ST2L protein precursor,
   human oligophrenin-4 and interleukin-18 receptor accessory protein, and
   Drosophila toll-like proteins.
  
   INTRLKN1R1F is a 7-element fingerprint that provides a signature for the
   interleukin-1 receptor type I family. The fingerprint was derived from an
   initial alignment of 10 sequences: the motifs were drawn from short
   conserved regions spanning the C-terminal half of the alignment, focusing 
   on those sections that characterise members of the interleukin-1 receptor
   type I family but distinguish them from other members of the interleukin-1
   receptor family - motif 1 encodes the putative TM domain; and motifs 2-7 
   span the cytoplasmic domain. Two iterations on SPTR39_15f were required to
   reach convergence, at which point a true set comprising 20 sequences was 
   identified. Several partial matches were also found, all of which are 
   Drosophila toll-like proteins that fail to make significant matches with
   one or more motifs.

  SUMMARY INFORMATION
     20 codes involving  7 elements
      0 codes involving  6 elements
      0 codes involving  5 elements
      1 codes involving  4 elements
      0 codes involving  3 elements
      3 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    7|  20   20   20   20   20   20   20  
    6|   0    0    0    0    0    0    0  
    5|   0    0    0    0    0    0    0  
    4|   0    1    1    1    0    0    1  
    3|   0    0    0    0    0    0    0  
    2|   0    3    0    3    0    0    0  
   --+------------------------------------
     |   1    2    3    4    5    6    7  

True positives..
 IL1R_HUMAN     IL1R_MOUSE     Q9TV71         IL1R_RAT       
 Q13525         Q90874         Q62929         Q62611         
 Q05208         Q9UJ53         Q9NZN1         Q61730         
 Q9NP60         O14915         Q63621         Q13478         
 Q9UQ44         Q61098         O95256         Q9Z2B1         
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 Q9JLZ8         
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 Q9NBK8         Q9XZF9         Q9VJX9         


  PROTEIN TITLES
   IL1R_HUMAN       INTERLEUKIN-1 RECEPTOR, TYPE I PRECURSOR (IL-1R-1) (IL-1R-AL
   IL1R_MOUSE       INTERLEUKIN-1 RECEPTOR, TYPE I PRECURSOR (IL-1R-1) (P80) - M
   Q9TV71           INTERLEUKIN-1 RECEPTOR TYPE I PRECURSOR - Equus caballus (Ho
   IL1R_RAT         INTERLEUKIN-1 RECEPTOR, TYPE I PRECURSOR (IL-1R-1) (P80) - R
   Q13525           INTERLEUKIN-1 RECEPTOR-RELATED PROTEIN - Homo sapiens (Human
   Q90874           IL-1 RECEPTOR I PRECURSOR - Gallus gallus (Chicken).
   Q62929           INTERLEUKIN-1 RECEPTOR-RELATED PROTEIN - Rattus norvegicus (
   Q62611           FIT-1M PRECURSOR - Rattus norvegicus (Rat).
   Q05208           ST2L PROTEIN PRECURSOR - Mus musculus (Mouse).
   Q9UJ53           OLIGOPHRENIN-4 - Homo sapiens (Human).
   Q9NZN1           X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1 - H
   Q61730           INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN PRECURSOR - Mus mus
   Q9NP60           IL1RAPL-2 RELATED PROTEIN (INTERLEUKIN-1 RECEPTOR 9) (IL-1 R
   O14915           IL-1 RECEPTOR ACCESSORY PROTEIN (MEMBRANE INTERLEUKIN 1 RECE
   Q63621           INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN - Rattus norvegicus
   Q13478           IL-1RRP PRECURSOR - Homo sapiens (Human).
   Q9UQ44           ST2L - Homo sapiens (Human).
   Q61098           INTERLEUKIN 1 RECEPTOR RELATED PROTEIN PRECURSOR (IL-1RRP) -
   O95256           INTERLEUKIN-18 RECEPTOR ACCESSORY PROTEIN-LIKE - Homo sapien
   Q9Z2B1           INTERLEUKIN-18 RECEPTOR ACCESSORY PROTEIN-LIKE - Mus musculu
 
   Q9JLZ8           TOLL/INTERLEUKIN-1 RECEPTOR 8 - Mus musculus (Mouse).
 
   Q9NBK8           TOLL-5 - Drosophila melanogaster (Fruit fly).
   Q9XZF9           TOLL LIKE PROTEIN - Drosophila melanogaster (Fruit fly).
   Q9VJX9           TEHAO PROTEIN - Drosophila melanogaster (Fruit fly).

SCAN HISTORY SPTR39_15f 2 50 NSINGLE INITIAL MOTIF SETS INTRLKN1R1F1 Length of motif = 29 Motif number = 1 Interleukin-1 receptor type I family motif I - 1 PCODE ST INT GICVTLTVIIVCSVFIYKIFKIDIVLWYR IL1R_HUMAN 340 340 GGFIILTATIVCCVCIYKVFKVDIVLWYR IL1R_MOUSE 343 343 GGFAIFTATAVFCACIYKVFKVDIVLWYR IL1R_RAT 343 343 GIFVLLTVAITCSVFIYKLFKVDLVLWYR Q9TV71 340 340 GGGISLIFLLFLILIVYKIFKIDIVLWYR Q90874 343 343 TVLVLASVAAVCIVILCVIYKVDLVLFYR Q61098 329 329 IIAVLILVAVVCLVTVCVIYRVDLVLFYR Q13478 332 332 GGLGAIFLLLVLLVVIYKCYNIELMLFYR Q9NP60 359 359 GGLGAILLLLVCLVTIYKCYKIEIMLFYR Q9NZN1 362 362 GGLIALVAVAVSVVYIYNIFKIDIVLWYR Q13525 340 340 AGCSLLLMFINVLVIVLKVFWIEVALFWR Q62611 338 338 AGCSLLLMFINVLVIVLKVFWIEVALFWR Q05208 339 339 AVCSVFLMLINVLVIILKMFWIEATLLWR Q9UQ44 334 334 LGTIGTLVAVLAASALLYRHWIEIVLLYR O95256 365 365 CGFGATVFLVVVLIVVYHVYWLEMVLFYR Q63621 362 362 GGLMAFLLLAVSILYIYNTFKVDIVLWYR Q62929 343 343 INTRLKN1R1F2 Length of motif = 15 Motif number = 2 Interleukin-1 receptor type I family motif II - 1 PCODE ST INT SDGKTYDAYILYPKT IL1R_HUMAN 380 11 SDGKTYDAYILYPKT IL1R_MOUSE 383 11 SDGRTYDAYVLYPKT IL1R_RAT 383 11 SDGKTYDAYILYPKI Q9TV71 380 11 SDGKIYDAYVLYPKN Q90874 383 11 TDGKTYDAFVSYLKE Q61098 367 9 TDGKTYDAFVSYLKE Q13478 370 9 DDNKEYDAYLSYTKV Q9NP60 397 9 GDNKDYDAYLSYTKV Q9NZN1 400 9 VDGKLYDAYVLYPKP Q13525 378 9 NDGKLYDAYIIYPRV Q62611 376 9 NDGKLYDAYIIYPRV Q05208 377 9 NDGKLYDAYVVYPRN Q9UQ44 372 9 GDKKDFDAFVSYAKW O95256 403 9 LDGKEYDIYVSYARN Q63621 400 9 DDEKLYDAYVLYPKY Q62929 381 9 INTRLKN1R1F3 Length of motif = 25 Motif number = 3 Interleukin-1 receptor type I family motif III - 1 PCODE ST INT DIFVFKVLPEVLEKQCGYKLFIYGR IL1R_HUMAN 404 9 DTFVFKLLPEVLEGQFGYKLFIYGR IL1R_MOUSE 407 9 DTFVFKLLPEVLEGQFGYKLFICGR IL1R_RAT 407 9 DIFVFKVLPEVLEKQCGYKLFIYGR Q9TV71 404 9 DIFALKILPEVLERQCGYNLFIFGR Q90874 406 8 YTFAVETLPRVLEKQFGYKLCIFER Q61098 390 8 HTFAVEILPRVLEKHFGYKLCIFER Q13478 393 8 EQFALEVLPDVLEKHYGYKLFIPER Q9NP60 424 12 ERFALEILPDMLEKHYGYKLFIPDR Q9NZN1 427 12 DALVLNILPEVLERQCGYKLFIFGR Q13525 402 9 EYFVHYTLPDVLENKCGYKLCIYGR Q62611 402 11 EYFVHHTLPDVLENKCGYKLCIYGR Q05208 403 11 EHFVHQILPDVLENKCGYTLCIYGR Q9UQ44 398 11 EHLALSLFPDVLENKYGYSLCLLER O95256 431 13 EEFVLLTLRGVLENEFGYKLCIFDR Q63621 418 3 DTLVLKILPEVLEKQCGYKLFIFGR Q62929 405 9 INTRLKN1R1F4 Length of motif = 28 Motif number = 4 Interleukin-1 receptor type I family motif IV - 1 PCODE ST INT DDYVGEDIVEVINENVKKSRRLIIILVR IL1R_HUMAN 429 0 DDYVGEDTIEVTNENVKKSRRLIIILVR IL1R_MOUSE 432 0 DDYVGEDTIEVTNENVKRSRRLIIILVR IL1R_RAT 432 0 DDYVGEDIVEVTNENIKKSRRLIIILVR Q9TV71 429 0 NDLAGEAVIDVTDEKIHQSRRVIIILVP Q90874 431 0 DVVPGGAVVEEIHSLIEKSRRLIIVLSQ Q61098 415 0 DVVPGGAVVDEIHSLIEKSRRLIIVLSK Q13478 418 0 DLIPSGTYMEDLTRYVEQSRRLIIVLTP Q9NP60 449 0 DLIPTGTYIEDVARCVDQSKRLIIVMTP Q9NZN1 452 0 DEFPGQAVANVIDENVKLCRRLIVIVVP Q13525 427 0 DLLPGQDAATVVESSIQNSRRQVFVLAP Q62611 427 0 DLLPGQDAATVVESSIQNSRRQVFVLAP Q05208 428 0 DMLPGEDVVTAVETNIRKSRRHIFILTP Q9UQ44 423 0 DVAPGGVYAEDIVSIIKRSRRGIFILSP O95256 456 0 DSFPGGIVTDETLSFIQKSRRLLVVLSP Q63621 443 0 DEFPGQAVASVIDENIKLCRRLMVLVAP Q62929 430 0 INTRLKN1R1F5 Length of motif = 26 Motif number = 5 Interleukin-1 receptor type I family motif V - 1 PCODE ST INT EEQIAMYNALVQDGIKVVLLELEKIQ IL1R_HUMAN 469 12 EEQIAIYNALIQEGIKIVLLELEKIQ IL1R_MOUSE 472 12 EEQIAIYDALIREGIKIILLELEKIQ IL1R_RAT 472 12 EEQIAMYNALVQDGIKIILLELEKIQ Q9TV71 469 12 EKHLAVYNALIQDGIKIILIELEKIE Q90874 471 12 ELESGLHEALVERKIKIILIEFTPAS Q61098 452 9 ELESGLHEALVERKIKIILIEFTPVT Q13478 455 9 ELESRLHNMLVSGEIKVILIECTELK Q9NP60 488 11 ELETRLRNMLVTGEIKVILIECSELR Q9NZN1 491 11 EEQIAVYSALIQDGMKVILIELEKIE Q13525 467 12 EQEIALHSALIQNNSKVILIEMEPMG Q62611 465 10 EQEIALHSALIQNNSKVILIEMEPLG Q05208 466 10 EQEVALHCALIQNDAKVILIEMEALS Q9UQ44 461 10 ELQAAVNLALDDQTLKLILIKFCYFQ O95256 493 9 ELKAGLENMASRGNINVILVQYKAVK Q63621 482 11 EEQIAVYNALVQDGMKVILIELERVK Q62929 470 12 INTRLKN1R1F6 Length of motif = 14 Motif number = 6 Interleukin-1 receptor type I family motif VI - 1 PCODE ST INT IKQKHGAIRWSGDF IL1R_HUMAN 506 11 IKQKHGVICWSGDF IL1R_MOUSE 509 11 IKQKHGAICWSGDF IL1R_RAT 509 11 IKRKHGALRWSGDS Q9TV71 506 11 VKQKYGAIRWTGDF Q90874 508 11 LLKSYRVLKWRADS Q61098 488 10 LLKSHRVLKWKADK Q13478 491 10 SIKLLSLIKWKGSK Q9NP60 527 13 TIKLLTVIKWHGPK Q9NZN1 530 13 IKQKHGAIRWHGDF Q13525 504 11 LVKMQGTIKWREDH Q62611 507 16 LVKIQGTIKWREDH Q05208 508 16 LMKVQGTIKWREDH Q9UQ44 503 16 ALRVLPTVTWRGLK O95256 530 11 AKSVLTVIKWKGEK Q63621 517 9 IRQKHGAIQWDGDF Q62929 507 11 INTRLKN1R1F7 Length of motif = 20 Motif number = 7 Interleukin-1 receptor type I family motif VII - 1 PCODE ST INT PQSAKTRFWKNVRYHMPVQR IL1R_HUMAN 523 3 PQSAKTRFWKNLRYQMPAQR IL1R_MOUSE 526 3 PQSAKTRFWKNLRYQMPAQR IL1R_RAT 526 3 PQSAKARFWKNVRYRMPVQR Q9TV71 523 3 SHSASTRFWKKVRYHMPSRK Q90874 525 3 SPSMNSRFWKNLVYLMPAKA Q61098 501 -1 SLSYNSRFWKNLLYLMPAKT Q13478 505 0 SSKLNSKFWKHLVYEMPIKK Q9NP60 541 0 CNKLNSKFWKRLQYEMPFKR Q9NZN1 544 0 SQCMKTKFWKTVRYHMPPRR Q13525 521 3 KQSLSSKFWKHVRYQMPVPK Q62611 524 3 KQSLSSKFWKHVRYQMPVPE Q05208 525 3 KRSLNSKFWKHVRYQMPVPS Q9UQ44 520 3 SVPPNSRFWAKMRYHMPVKN O95256 544 0 SKYPQGRFWKQLQVAMPVKK Q63621 531 0 AQCAKTKFWKKVRYHMPPRR Q62929 524 3 FINAL MOTIF SETS INTRLKN1R1F1 Length of motif = 29 Motif number = 1 Interleukin-1 receptor type I family motif I - 2 PCODE ST INT GICVTLTVIIVCSVFIYKIFKIDIVLWYR IL1R_HUMAN 340 340 GGFIILTATIVCCVCIYKVFKVDIVLWYR IL1R_MOUSE 343 343 GIFVLLTVAITCSVFIYKLFKVDLVLWYR Q9TV71 340 340 GGFAIFTATAVFCACIYKVFKVDIVLWYR IL1R_RAT 343 343 GGLIALVAVAVSVVYIYNIFKIDIVLWYR Q13525 340 340 GGGISLIFLLFLILIVYKIFKIDIVLWYR Q90874 343 343 GGLMAFLLLAVSILYIYNTFKVDIVLWYR Q62929 343 343 AGCSLLLMFINVLVIVLKVFWIEVALFWR Q62611 338 338 AGCSLLLMFINVLVIVLKVFWIEVALFWR Q05208 339 339 GGLGAILLLLVCLVTIYKCYKIEIMLFYR Q9NZN1 362 362 GGLGAILLLLVCLVTIYKCYKIEIMLFYR Q9UJ53 362 362 CGFGATVFLVVVLIVVYHVYWLEMVLFYR Q61730 362 362 GGLGAIFLLLVLLVVIYKCYNIELMLFYR Q9NP60 359 359 CGFGATVLLVVILIVVYHVYWLEMVLFYR O14915 362 362 CGFGATVFLVVVLIVVYHVYWLEMVLFYR Q63621 362 362 IIAVLILVAVVCLVTVCVIYRVDLVLFYR Q13478 332 332 AVCSVFLMLINVLVIILKMFWIEATLLWR Q9UQ44 334 334 TVLVLASVAAVCIVILCVIYKVDLVLFYR Q61098 329 329 LGTIGTLVAVLAASALLYRHWIEIVLLYR O95256 365 365 LGTALMLVGVLVAAAFLYWYWIEVVLLCR Q9Z2B1 364 364 INTRLKN1R1F2 Length of motif = 15 Motif number = 2 Interleukin-1 receptor type I family motif II - 2 PCODE ST INT SDGKTYDAYILYPKT IL1R_HUMAN 380 11 SDGKTYDAYILYPKT IL1R_MOUSE 383 11 SDGKTYDAYILYPKI Q9TV71 380 11 SDGRTYDAYVLYPKT IL1R_RAT 383 11 VDGKLYDAYVLYPKP Q13525 378 9 SDGKIYDAYVLYPKN Q90874 383 11 DDEKLYDAYVLYPKY Q62929 381 9 NDGKLYDAYIIYPRV Q62611 376 9 NDGKLYDAYIIYPRV Q05208 377 9 GDNKDYDAYLSYTKV Q9NZN1 400 9 GDNKDYDAYLSYTKV Q9UJ53 400 9 LDGKEYDIYVSYARN Q61730 400 9 DDNKEYDAYLSYTKV Q9NP60 397 9 LDGKEYDIYVSYARN O14915 400 9 LDGKEYDIYVSYARN Q63621 400 9 TDGKTYDAFVSYLKE Q13478 370 9 NDGKLYDAYVVYPRN Q9UQ44 372 9 TDGKTYDAFVSYLKE Q61098 367 9 GDKKDFDAFVSYAKW O95256 403 9 GDKKEFDAFVSYSNW Q9Z2B1 402 9 INTRLKN1R1F3 Length of motif = 25 Motif number = 3 Interleukin-1 receptor type I family motif III - 2 PCODE ST INT DIFVFKVLPEVLEKQCGYKLFIYGR IL1R_HUMAN 404 9 DTFVFKLLPEVLEGQFGYKLFIYGR IL1R_MOUSE 407 9 DIFVFKVLPEVLEKQCGYKLFIYGR Q9TV71 404 9 DTFVFKLLPEVLEGQFGYKLFICGR IL1R_RAT 407 9 DALVLNILPEVLERQCGYKLFIFGR Q13525 402 9 DIFALKILPEVLERQCGYNLFIFGR Q90874 406 8 DTLVLKILPEVLEKQCGYKLFIFGR Q62929 405 9 EYFVHYTLPDVLENKCGYKLCIYGR Q62611 402 11 EYFVHHTLPDVLENKCGYKLCIYGR Q05208 403 11 ERFALEILPDMLEKHYGYKLFIPDR Q9NZN1 427 12 ERFALEILPDMLEKHYGYKLFIPDR Q9UJ53 427 12 EEFVLLTLRGVLENEFGYKLCIFDR Q61730 418 3 EQFALEVLPDVLEKHYGYKLFIPER Q9NP60 424 12 EEFVLLTLRGVLENEFGYKLCIFDR O14915 418 3 EEFVLLTLRGVLENEFGYKLCIFDR Q63621 418 3 HTFAVEILPRVLEKHFGYKLCIFER Q13478 393 8 EHFVHQILPDVLENKCGYTLCIYGR Q9UQ44 398 11 YTFAVETLPRVLEKQFGYKLCIFER Q61098 390 8 EHLALSLFPDVLENKYGYSLCLLER O95256 431 13 EHLALNLFPEVLEDTYGYRLCLLDR Q9Z2B1 430 13 INTRLKN1R1F4 Length of motif = 28 Motif number = 4 Interleukin-1 receptor type I family motif IV - 2 PCODE ST INT DDYVGEDIVEVINENVKKSRRLIIILVR IL1R_HUMAN 429 0 DDYVGEDTIEVTNENVKKSRRLIIILVR IL1R_MOUSE 432 0 DDYVGEDIVEVTNENIKKSRRLIIILVR Q9TV71 429 0 DDYVGEDTIEVTNENVKRSRRLIIILVR IL1R_RAT 432 0 DEFPGQAVANVIDENVKLCRRLIVIVVP Q13525 427 0 NDLAGEAVIDVTDEKIHQSRRVIIILVP Q90874 431 0 DEFPGQAVASVIDENIKLCRRLMVLVAP Q62929 430 0 DLLPGQDAATVVESSIQNSRRQVFVLAP Q62611 427 0 DLLPGQDAATVVESSIQNSRRQVFVLAP Q05208 428 0 DLIPTGTYIEDVARCVDQSKRLIIVMTP Q9NZN1 452 0 DLIPTGTYIEDVARCVDQSKRLIIVMTP Q9UJ53 452 0 DSLPGGIVTDETLSFIQKSRRLLVVLSP Q61730 443 0 DLIPSGTYMEDLTRYVEQSRRLIIVLTP Q9NP60 449 0 DSLPGGIVTDETLSFIQKSRRLLVVLSP O14915 443 0 DSFPGGIVTDETLSFIQKSRRLLVVLSP Q63621 443 0 DVVPGGAVVDEIHSLIEKSRRLIIVLSK Q13478 418 0 DMLPGEDVVTAVETNIRKSRRHIFILTP Q9UQ44 423 0 DVVPGGAVVEEIHSLIEKSRRLIIVLSQ Q61098 415 0 DVAPGGVYAEDIVSIIKRSRRGIFILSP O95256 456 0 DVTPGGVYADDIVSIIKKSRRGIFILSP Q9Z2B1 455 0 INTRLKN1R1F5 Length of motif = 26 Motif number = 5 Interleukin-1 receptor type I family motif V - 2 PCODE ST INT EEQIAMYNALVQDGIKVVLLELEKIQ IL1R_HUMAN 469 12 EEQIAIYNALIQEGIKIVLLELEKIQ IL1R_MOUSE 472 12 EEQIAMYNALVQDGIKIILLELEKIQ Q9TV71 469 12 EEQIAIYDALIREGIKIILLELEKIQ IL1R_RAT 472 12 EEQIAVYSALIQDGMKVILIELEKIE Q13525 467 12 EKHLAVYNALIQDGIKIILIELEKIE Q90874 471 12 EEQIAVYNALVQDGMKVILIELERVK Q62929 470 12 EQEIALHSALIQNNSKVILIEMEPMG Q62611 465 10 EQEIALHSALIQNNSKVILIEMEPLG Q05208 466 10 ELETRLRNMLVTGEIKVILIECSELR Q9NZN1 491 11 ELETRLRNMLVTGEIKVILIECSELR Q9UJ53 491 11 ELKAGLENMASRGNINVILVQYKAVK Q61730 482 11 ELESRLHNMLVSGEIKVILIECTELK Q9NP60 488 11 ELKAGLENMASRGNINVILVQYKAVK O14915 482 11 ELKAGLENMASRGNINVILVQYKAVK Q63621 482 11 ELESGLHEALVERKIKIILIEFTPVT Q13478 455 9 EQEVALHCALIQNDAKVILIEMEALS Q9UQ44 461 10 ELESGLHEALVERKIKIILIEFTPAS Q61098 452 9 ELQAAVNLALDDQTLKLILIKFCYFQ O95256 493 9 ELQAAVNLALVDQTLKLILIKFCSFQ Q9Z2B1 492 9 INTRLKN1R1F6 Length of motif = 14 Motif number = 6 Interleukin-1 receptor type I family motif VI - 2 PCODE ST INT IKQKHGAIRWSGDF IL1R_HUMAN 506 11 IKQKHGVICWSGDF IL1R_MOUSE 509 11 IKRKHGALRWSGDS Q9TV71 506 11 IKQKHGAICWSGDF IL1R_RAT 509 11 IKQKHGAIRWHGDF Q13525 504 11 VKQKYGAIRWTGDF Q90874 508 11 IRQKHGAIQWDGDF Q62929 507 11 LVKMQGTIKWREDH Q62611 507 16 LVKIQGTIKWREDH Q05208 508 16 TIKLLTVIKWHGPK Q9NZN1 530 13 TIKLLTVIKWHGPK Q9UJ53 530 13 AKTVLTVIKWKGEK Q61730 517 9 SIKLLSLIKWKGSK Q9NP60 527 13 AKTVLTVIKWKGEK O14915 517 9 AKSVLTVIKWKGEK Q63621 517 9 LLKSHRVLKWKADK Q13478 491 10 LMKVQGTIKWREDH Q9UQ44 503 16 LLKSYRVLKWRADS Q61098 488 10 ALRVLPTVTWRGLK O95256 530 11 ALRVLPTVTWKGLK Q9Z2B1 529 11 INTRLKN1R1F7 Length of motif = 20 Motif number = 7 Interleukin-1 receptor type I family motif VII - 2 PCODE ST INT PQSAKTRFWKNVRYHMPVQR IL1R_HUMAN 523 3 PQSAKTRFWKNLRYQMPAQR IL1R_MOUSE 526 3 PQSAKARFWKNVRYRMPVQR Q9TV71 523 3 PQSAKTRFWKNLRYQMPAQR IL1R_RAT 526 3 SQCMKTKFWKTVRYHMPPRR Q13525 521 3 SHSASTRFWKKVRYHMPSRK Q90874 525 3 AQCAKTKFWKKVRYHMPPRR Q62929 524 3 KQSLSSKFWKHVRYQMPVPK Q62611 524 3 KQSLSSKFWKHVRYQMPVPE Q05208 525 3 CNKLNSKFWKRLQYEMPFKR Q9NZN1 544 0 CNKLNSKFWKRLQYEMPFKR Q9UJ53 544 0 SKYPQGRFWKQLQVAMPVKK Q61730 531 0 SSKLNSKFWKHLVYEMPIKK Q9NP60 541 0 SKYPQGRFWKQLQVAMPVKK O14915 531 0 SKYPQGRFWKQLQVAMPVKK Q63621 531 0 SLSYNSRFWKNLLYLMPAKT Q13478 505 0 KRSLNSKFWKHVRYQMPVPS Q9UQ44 520 3 SPSMNSRFWKNLVYLMPAKA Q61098 501 -1 SVPPNSRFWAKMRYHMPVKN O95256 544 0 SVHASSRFWTQIRYHMPVKN Q9Z2B1 543 0

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