WORKLIST ENTRIES (1):
DERENTRNSPRT View alignment Delayed-early response protein/equilibrative nucleoside transporter signature
Type of fingerprint: COMPOUND with 9 elements
Links:
INTERPRO; IPR002259
Creation date 21-MAY-1999
1. WILLIAMS, J.B. AND LANAHAN, A.A.
A mammalian delayed-early response gene encodes HNP36, a novel, conserved
nucleolar protein.
BIOCHEM.BIOPHYS.RES.COMMUN. 213(1) 325-333 (1995).
Delayed-early response (DER) gene products include growth progression
factors and several unknown products of novel cDNAs. Murine and human cDNAs
from one novel DER gene (DER12) have been characterised to identify its
product and to examine its role in the growth response [1]. Both sequences
encode a hydrophobic 36kDa protein that is predicted to contain 8 trans-
membrane (TM) domains. The protein has been localised to the nucleolus,
where its concentration increases following mitogen stimulation [1].
Although the function fo the protein is unknown, its identification as a
nucleolar gene transcriptionally activated by growth factors implicates it
as participating in the proliferative response [1]. Sequence analysis
reveals the protein to share a high degree of similarity with the C-terminal
portion of equilibrative nucleoside transporters.
DERENTRNSPRT is a 9-element fingerprint that provides a signature for
delayed-early response proteins, DER12, and equilibrative nucleoside
transporters. The fingerprint was derived from an initial alignment of
2 sequences: the motifs were drawn from conserved regions spanning virtually
the full alignment length: motifs 1-7 and 9 each reside within putative TM
domains. Two iterations on SPTR37_9f were required to reach convergence, at
which point a true set comprising 6 sequences was identified.
SUMMARY INFORMATION
6 codes involving 9 elements
0 codes involving 8 elements
0 codes involving 7 elements
0 codes involving 6 elements
0 codes involving 5 elements
0 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
9| 6 6 6 6 6 6 6 6 6
8| 0 0 0 0 0 0 0 0 0
7| 0 0 0 0 0 0 0 0 0
6| 0 0 0 0 0 0 0 0 0
5| 0 0 0 0 0 0 0 0 0
4| 0 0 0 0 0 0 0 0 0
3| 0 0 0 0 0 0 0 0 0
2| 0 0 0 0 0 0 0 0 0
--+----------------------------------------------
| 1 2 3 4 5 6 7 8 9
True positives..
O43530 HN36_MOUSE HN36_HUMAN O54699
Q99808 O54698
PROTEIN TITLES
O43530 NBMPR-INSENSITIVE NUCLEOSIDE TRANSPORTER EI - HOMO SAPIENS (
HN36_MOUSE 36 KD NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEI
HN36_HUMAN 36 KD NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEI
O54699 EQUILBRATIVE NITROBENZYLTHIOINOSINE-INSENSITIVE NUCLEOSIDE T
Q99808 EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 - HOMO SAPIENS (HUMAN
O54698 EQUILBRATIVE NITROBENZYLTHIOINOSINE-SENSITIVE NUCLEOSIDE TRA
SCAN HISTORY
SPTR37_9f 2 8 NSINGLE
INITIAL MOTIF SETS
DERENTRNSPRT1 Length of motif = 23 Motif number = 1
Delayed-early response protein motif I - 1
PCODE ST INT
INSFCAVLQGSLFGQLGTMPSTY HN36_MOUSE 7 7
INSFSAVLQGSLFGQLGTMPSTY HN36_HUMAN 7 7
DERENTRNSPRT2 Length of motif = 21 Motif number = 2
Delayed-early response protein motif II - 1
PCODE ST INT
SGQGLAGIFAALAMLMSLASG HN36_MOUSE 35 5
SGQGLAGIFAALAMLLSMASG HN36_HUMAN 35 5
DERENTRNSPRT3 Length of motif = 24 Motif number = 3
Delayed-early response protein motif III - 1
PCODE ST INT
SALGYFITPCVGILLSIVCYLSLP HN36_MOUSE 61 5
SALGYFITPYVGILMSIVCYLSLP HN36_HUMAN 61 5
DERENTRNSPRT4 Length of motif = 18 Motif number = 4
Delayed-early response protein motif IV - 1
PCODE ST INT
FTVTLSVFPAITAMVTTS HN36_MOUSE 170 85
FTVTLSVFPAITAMVTSS HN36_HUMAN 171 86
DERENTRNSPRT5 Length of motif = 22 Motif number = 5
Delayed-early response protein motif V - 1
PCODE ST INT
CFLLFNVMDWLGRSLTSYFLWP HN36_MOUSE 203 15
CFLLFNIMDWLGRSLTSYFLWP HN36_HUMAN 203 14
DERENTRNSPRT6 Length of motif = 18 Motif number = 6
Delayed-early response protein motif VI - 1
PCODE ST INT
LPLLVCLRFLFVPLFMLC HN36_MOUSE 232 7
LPLLVCLRFLFVPLFMLC HN36_HUMAN 231 6
DERENTRNSPRT7 Length of motif = 17 Motif number = 7
Delayed-early response protein motif VII - 1
PCODE ST INT
DAYFITFMLLFAVSNGY HN36_MOUSE 264 14
DAYFITFMLLFAVSNGY HN36_HUMAN 263 14
DERENTRNSPRT8 Length of motif = 17 Motif number = 8
Delayed-early response protein motif VIII - 1
PCODE ST INT
SLTMCLAPRQVLPHERE HN36_MOUSE 283 2
SLTMCLAPRQVLPHERE HN36_HUMAN 282 2
DERENTRNSPRT9 Length of motif = 25 Motif number = 9
Delayed-early response protein motif IX - 1
PCODE ST INT
AGALMTFFLALGLSCGASLSFLFKA HN36_MOUSE 301 1
AGALMTFFLALGLSCGASLSFLFKA HN36_HUMAN 300 1
FINAL MOTIF SETS
DERENTRNSPRT1 Length of motif = 23 Motif number = 1
Delayed-early response protein motif I - 2
PCODE ST INT
INSFSAVLQGSLFGQLGTMPSTY O43530 137 137
INSFCAVLQGSLFGQLGTMPSTY HN36_MOUSE 7 7
INSFSAVLQGSLFGQLGTMPSTY HN36_HUMAN 7 7
INSFCAVLQGSLFGQLGTMPSTY O54699 136 136
INSFGAILQGSLFGLAGLLPASY Q99808 150 150
INSFGAILQASLFGLAGVLPANY O54698 150 150
DERENTRNSPRT2 Length of motif = 21 Motif number = 2
Delayed-early response protein motif II - 2
PCODE ST INT
SGQGLAGIFAALAMLLSMASG O43530 165 5
SGQGLAGIFAALAMLMSLASG HN36_MOUSE 35 5
SGQGLAGIFAALAMLLSMASG HN36_HUMAN 35 5
SGQGLAGIFAALAMLTSLASG O54699 164 5
SGQGLAGFFASVAMICAIASG Q99808 178 5
SGQGLAGFFTSVAMICAVASG O54698 178 5
DERENTRNSPRT3 Length of motif = 24 Motif number = 3
Delayed-early response protein motif III - 2
PCODE ST INT
SALGYFITPCVGILMSIVCYLSLP O43530 191 5
SALGYFITPCVGILLSIVCYLSLP HN36_MOUSE 61 5
SALGYFITPYVGILMSIVCYLSLP HN36_HUMAN 61 5
SALGYFITPCVGILLSIICYLSLP O54699 190 5
SAFGYFITACAVIILTIICYLGLP Q99808 204 5
SAFGYFITACAVVILAILCYLALP O54698 204 5
DERENTRNSPRT4 Length of motif = 18 Motif number = 4
Delayed-early response protein motif IV - 2
PCODE ST INT
FTVTLSVFPAITAMVTSS O43530 301 86
FTVTLSVFPAITAMVTTS HN36_MOUSE 170 85
FTVTLSVFPAITAMVTSS HN36_HUMAN 171 86
FTVTLSVFPAITAMVTTS O54699 300 86
FTITIGMFPAVTVEVKSS Q99808 300 72
FTVTIGLFPAVTAEVESS O54698 300 72
DERENTRNSPRT5 Length of motif = 22 Motif number = 5
Delayed-early response protein motif V - 2
PCODE ST INT
CFLLFNIMDWLGRSLTSYFLWP O43530 333 14
CFLLFNVMDWLGRSLTSYFLWP HN36_MOUSE 203 15
CFLLFNIMDWLGRSLTSYFLWP HN36_HUMAN 203 14
CFLLFNVMDWLGRSLTSYFLWP O54699 333 15
CFLTFNIFDWLGRSLTAVFMWP Q99808 333 15
CFLNFNVFDWLGRSLTAICMWP O54698 334 16
DERENTRNSPRT6 Length of motif = 18 Motif number = 6
Delayed-early response protein motif VI - 2
PCODE ST INT
LPLLVCLRFLFVPLFMLC O43530 361 6
LPLLVCLRFLFVPLFMLC HN36_MOUSE 232 7
LPLLVCLRFLFVPLFMLC HN36_HUMAN 231 6
LPLLVCLRFLFVPLFMLC O54699 361 6
LPSLVLARLVFVPLLLLC Q99808 361 6
LPVLVACRVVFIPLLMLC O54698 362 6
DERENTRNSPRT7 Length of motif = 17 Motif number = 7
Delayed-early response protein motif VII - 2
PCODE ST INT
DAYFITFMLLFAVSNGY O43530 393 14
DAYFITFMLLFAVSNGY HN36_MOUSE 264 14
DAYFITFMLLFAVSNGY HN36_HUMAN 263 14
DAYFITFMLLFAISNGY O54699 393 14
DAWFIFFMAAFAFSNGY Q99808 393 14
DVWFITFMAAFAFSNGY O54698 394 14
DERENTRNSPRT8 Length of motif = 17 Motif number = 8
Delayed-early response protein motif VIII - 2
PCODE ST INT
SLTMCLAPRQVLPHERE O43530 412 2
SLTMCLAPRQVLPHERE HN36_MOUSE 283 2
SLTMCLAPRQVLPHERE HN36_HUMAN 282 2
SLTMCLAPRQVLPHERE O54699 412 2
SLCMCFGPKKVKPAEAE Q99808 412 2
SLCMCFGPKKVKPAEAE O54698 413 2
DERENTRNSPRT9 Length of motif = 25 Motif number = 9
Delayed-early response protein motif IX - 2
PCODE ST INT
AGALMTFFLALGLSCGASLSFLFKA O43530 430 1
AGALMTFFLALGLSCGASLSFLFKA HN36_MOUSE 301 1
AGALMTFFLALGLSCGASLSFLFKA HN36_HUMAN 300 1
AGALMTFFLALGLSCGASLSFLFKA O54699 430 1
AGAIMAFFLCLGLALGAVFSFLFRA Q99808 430 1
AGNIMSFFLCLGLALGAVLSFLLRA O54698 431 1
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