WORKLIST ENTRIES (1):

DERENTRNSPRT View alignment     Delayed-early response protein/equilibrative nucleoside transporter signature 
 Type of fingerprint: COMPOUND with 9  elements
Links:
   INTERPRO; IPR002259

 Creation date 21-MAY-1999

   1. WILLIAMS, J.B. AND LANAHAN, A.A.
   A mammalian delayed-early response gene encodes HNP36, a novel, conserved
   nucleolar protein.
   BIOCHEM.BIOPHYS.RES.COMMUN. 213(1) 325-333 (1995).

   Delayed-early response (DER) gene products include growth progression 
   factors and several unknown products of novel cDNAs. Murine and human cDNAs
   from one novel DER gene (DER12) have been characterised to identify its 
   product and to examine its role in the growth response [1]. Both sequences
   encode a hydrophobic 36kDa protein that is predicted to contain 8 trans-
   membrane (TM) domains. The protein has been localised to the nucleolus,
   where its concentration increases following mitogen stimulation [1]. 
  
   Although the function fo the protein is unknown, its identification as a 
   nucleolar gene transcriptionally activated by growth factors implicates it
   as participating in the proliferative response [1]. Sequence analysis
   reveals the protein to share a high degree of similarity with the C-terminal
   portion of equilibrative nucleoside transporters.
  
   DERENTRNSPRT is a 9-element fingerprint that provides a signature for 
   delayed-early response proteins, DER12, and equilibrative nucleoside 
   transporters. The fingerprint was derived from an initial alignment of
   2 sequences: the motifs were drawn from conserved regions spanning virtually
   the full alignment length: motifs 1-7 and 9 each reside within putative TM
   domains. Two iterations on SPTR37_9f were required to reach convergence, at
   which point a true set comprising 6 sequences was identified.

  SUMMARY INFORMATION
      6 codes involving  9 elements
      0 codes involving  8 elements
      0 codes involving  7 elements
      0 codes involving  6 elements
      0 codes involving  5 elements
      0 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    9|   6    6    6    6    6    6    6    6    6  
    8|   0    0    0    0    0    0    0    0    0  
    7|   0    0    0    0    0    0    0    0    0  
    6|   0    0    0    0    0    0    0    0    0  
    5|   0    0    0    0    0    0    0    0    0  
    4|   0    0    0    0    0    0    0    0    0  
    3|   0    0    0    0    0    0    0    0    0  
    2|   0    0    0    0    0    0    0    0    0  
   --+----------------------------------------------
     |   1    2    3    4    5    6    7    8    9  

True positives..
 O43530         HN36_MOUSE     HN36_HUMAN     O54699         
 Q99808         O54698         


  PROTEIN TITLES
   O43530           NBMPR-INSENSITIVE NUCLEOSIDE TRANSPORTER EI - HOMO SAPIENS (
   HN36_MOUSE       36 KD NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEI
   HN36_HUMAN       36 KD NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEI
   O54699           EQUILBRATIVE NITROBENZYLTHIOINOSINE-INSENSITIVE NUCLEOSIDE T
   Q99808           EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 - HOMO SAPIENS (HUMAN
   O54698           EQUILBRATIVE NITROBENZYLTHIOINOSINE-SENSITIVE NUCLEOSIDE TRA

SCAN HISTORY SPTR37_9f 2 8 NSINGLE INITIAL MOTIF SETS DERENTRNSPRT1 Length of motif = 23 Motif number = 1 Delayed-early response protein motif I - 1 PCODE ST INT INSFCAVLQGSLFGQLGTMPSTY HN36_MOUSE 7 7 INSFSAVLQGSLFGQLGTMPSTY HN36_HUMAN 7 7 DERENTRNSPRT2 Length of motif = 21 Motif number = 2 Delayed-early response protein motif II - 1 PCODE ST INT SGQGLAGIFAALAMLMSLASG HN36_MOUSE 35 5 SGQGLAGIFAALAMLLSMASG HN36_HUMAN 35 5 DERENTRNSPRT3 Length of motif = 24 Motif number = 3 Delayed-early response protein motif III - 1 PCODE ST INT SALGYFITPCVGILLSIVCYLSLP HN36_MOUSE 61 5 SALGYFITPYVGILMSIVCYLSLP HN36_HUMAN 61 5 DERENTRNSPRT4 Length of motif = 18 Motif number = 4 Delayed-early response protein motif IV - 1 PCODE ST INT FTVTLSVFPAITAMVTTS HN36_MOUSE 170 85 FTVTLSVFPAITAMVTSS HN36_HUMAN 171 86 DERENTRNSPRT5 Length of motif = 22 Motif number = 5 Delayed-early response protein motif V - 1 PCODE ST INT CFLLFNVMDWLGRSLTSYFLWP HN36_MOUSE 203 15 CFLLFNIMDWLGRSLTSYFLWP HN36_HUMAN 203 14 DERENTRNSPRT6 Length of motif = 18 Motif number = 6 Delayed-early response protein motif VI - 1 PCODE ST INT LPLLVCLRFLFVPLFMLC HN36_MOUSE 232 7 LPLLVCLRFLFVPLFMLC HN36_HUMAN 231 6 DERENTRNSPRT7 Length of motif = 17 Motif number = 7 Delayed-early response protein motif VII - 1 PCODE ST INT DAYFITFMLLFAVSNGY HN36_MOUSE 264 14 DAYFITFMLLFAVSNGY HN36_HUMAN 263 14 DERENTRNSPRT8 Length of motif = 17 Motif number = 8 Delayed-early response protein motif VIII - 1 PCODE ST INT SLTMCLAPRQVLPHERE HN36_MOUSE 283 2 SLTMCLAPRQVLPHERE HN36_HUMAN 282 2 DERENTRNSPRT9 Length of motif = 25 Motif number = 9 Delayed-early response protein motif IX - 1 PCODE ST INT AGALMTFFLALGLSCGASLSFLFKA HN36_MOUSE 301 1 AGALMTFFLALGLSCGASLSFLFKA HN36_HUMAN 300 1 FINAL MOTIF SETS DERENTRNSPRT1 Length of motif = 23 Motif number = 1 Delayed-early response protein motif I - 2 PCODE ST INT INSFSAVLQGSLFGQLGTMPSTY O43530 137 137 INSFCAVLQGSLFGQLGTMPSTY HN36_MOUSE 7 7 INSFSAVLQGSLFGQLGTMPSTY HN36_HUMAN 7 7 INSFCAVLQGSLFGQLGTMPSTY O54699 136 136 INSFGAILQGSLFGLAGLLPASY Q99808 150 150 INSFGAILQASLFGLAGVLPANY O54698 150 150 DERENTRNSPRT2 Length of motif = 21 Motif number = 2 Delayed-early response protein motif II - 2 PCODE ST INT SGQGLAGIFAALAMLLSMASG O43530 165 5 SGQGLAGIFAALAMLMSLASG HN36_MOUSE 35 5 SGQGLAGIFAALAMLLSMASG HN36_HUMAN 35 5 SGQGLAGIFAALAMLTSLASG O54699 164 5 SGQGLAGFFASVAMICAIASG Q99808 178 5 SGQGLAGFFTSVAMICAVASG O54698 178 5 DERENTRNSPRT3 Length of motif = 24 Motif number = 3 Delayed-early response protein motif III - 2 PCODE ST INT SALGYFITPCVGILMSIVCYLSLP O43530 191 5 SALGYFITPCVGILLSIVCYLSLP HN36_MOUSE 61 5 SALGYFITPYVGILMSIVCYLSLP HN36_HUMAN 61 5 SALGYFITPCVGILLSIICYLSLP O54699 190 5 SAFGYFITACAVIILTIICYLGLP Q99808 204 5 SAFGYFITACAVVILAILCYLALP O54698 204 5 DERENTRNSPRT4 Length of motif = 18 Motif number = 4 Delayed-early response protein motif IV - 2 PCODE ST INT FTVTLSVFPAITAMVTSS O43530 301 86 FTVTLSVFPAITAMVTTS HN36_MOUSE 170 85 FTVTLSVFPAITAMVTSS HN36_HUMAN 171 86 FTVTLSVFPAITAMVTTS O54699 300 86 FTITIGMFPAVTVEVKSS Q99808 300 72 FTVTIGLFPAVTAEVESS O54698 300 72 DERENTRNSPRT5 Length of motif = 22 Motif number = 5 Delayed-early response protein motif V - 2 PCODE ST INT CFLLFNIMDWLGRSLTSYFLWP O43530 333 14 CFLLFNVMDWLGRSLTSYFLWP HN36_MOUSE 203 15 CFLLFNIMDWLGRSLTSYFLWP HN36_HUMAN 203 14 CFLLFNVMDWLGRSLTSYFLWP O54699 333 15 CFLTFNIFDWLGRSLTAVFMWP Q99808 333 15 CFLNFNVFDWLGRSLTAICMWP O54698 334 16 DERENTRNSPRT6 Length of motif = 18 Motif number = 6 Delayed-early response protein motif VI - 2 PCODE ST INT LPLLVCLRFLFVPLFMLC O43530 361 6 LPLLVCLRFLFVPLFMLC HN36_MOUSE 232 7 LPLLVCLRFLFVPLFMLC HN36_HUMAN 231 6 LPLLVCLRFLFVPLFMLC O54699 361 6 LPSLVLARLVFVPLLLLC Q99808 361 6 LPVLVACRVVFIPLLMLC O54698 362 6 DERENTRNSPRT7 Length of motif = 17 Motif number = 7 Delayed-early response protein motif VII - 2 PCODE ST INT DAYFITFMLLFAVSNGY O43530 393 14 DAYFITFMLLFAVSNGY HN36_MOUSE 264 14 DAYFITFMLLFAVSNGY HN36_HUMAN 263 14 DAYFITFMLLFAISNGY O54699 393 14 DAWFIFFMAAFAFSNGY Q99808 393 14 DVWFITFMAAFAFSNGY O54698 394 14 DERENTRNSPRT8 Length of motif = 17 Motif number = 8 Delayed-early response protein motif VIII - 2 PCODE ST INT SLTMCLAPRQVLPHERE O43530 412 2 SLTMCLAPRQVLPHERE HN36_MOUSE 283 2 SLTMCLAPRQVLPHERE HN36_HUMAN 282 2 SLTMCLAPRQVLPHERE O54699 412 2 SLCMCFGPKKVKPAEAE Q99808 412 2 SLCMCFGPKKVKPAEAE O54698 413 2 DERENTRNSPRT9 Length of motif = 25 Motif number = 9 Delayed-early response protein motif IX - 2 PCODE ST INT AGALMTFFLALGLSCGASLSFLFKA O43530 430 1 AGALMTFFLALGLSCGASLSFLFKA HN36_MOUSE 301 1 AGALMTFFLALGLSCGASLSFLFKA HN36_HUMAN 300 1 AGALMTFFLALGLSCGASLSFLFKA O54699 430 1 AGAIMAFFLCLGLALGAVFSFLFRA Q99808 430 1 AGNIMSFFLCLGLALGAVLSFLLRA O54698 431 1

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