WORKLIST ENTRIES (1):

C2DOMAIN View alignment View Structure        C2 domain signature
 Type of fingerprint: COMPOUND with 3  elements
Links:
   PRINTS; PR00399 SYNAPTOTAGMN
   INTERPRO; IPR000008
   PROSITE; PS00499 C2_DOMAIN
   PFAM; PF00168 C2

 Creation date 06-JUL-1995; UPDATE 23-JUN-1999

   1. SUTTON, R.B., DAVLETOV, B.A., BERGHUIS, A.M., SUDHOF, T.C.
   AND SPRANG, S.R.
   Structure of the first C2 domain of synaptotagmin I: a novel
   Ca2+/phospholipid-binding fold.
   CELL 80 929-938 (1995).

   C2 domains are Ca2+-regulatory domains found widely in nature. To date,
   more than 40 distinct C2 domains have been identified, for example in
   proteins such as synaptotagmin, phospholipase A2, GTPase-activating
   proteins, rabphilin and phospholipase C isoforms [1]. The domains show
   no sequence similarity to other Ca2+-binding proteins; they thus
   constitute a novel family of Ca2+-regulatory motifs, which also
   includes members that have lost their calcium regulation.
  
   The structure of C2 domains in synaptotagmin I has been deduced: the C2
   polypeptide forms an 8-stranded beta-sandwich constructed around a 
   conserved 4-stranded motif, designated a C2 key [1]. Calcium binds in
   a cup-shaped depression formed by the N- and C-terminal loops of the
   C2-key motif.
  
   C2DOMAIN is a 3-element fingerprint that provides a signature for C2
   domains. The fingerprint was derived from an initial alignment of 12
   sequences: the motifs were drawn from short conserved regions within
   the C2-key core, corresponding to strands 3, 5 and 6 res., and including
   3 of the 4 acidic residues involved in Ca2+ ligation. Three iterations on
   OWL26.0 were required to reach convergence, at which point a true set
   comprising 74 sequences was identified. Several partial matches were
   also found, which was to be expected since the degree of sequence
   divergence was high and the motifs therefore relatively short.
  
   An update on SPTR37_9f identified a true set of 86 sequences, and 38
   partial matches.

  SUMMARY INFORMATION
     86 codes involving  3 elements
     38 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    3|  86   86   86  
    2|  23   36   17  
   --+----------------
     |   1    2    3  

True positives..
 KPCG_RABIT     KPCG_MOUSE     KPCG_HUMAN     P90981         
 P90980         Q19025         KPCA_HUMAN     KPCA_RABIT     
 KPCA_RAT       SY65_APLCA     SYT1_RAT       SYT1_MOUSE     
 SYT1_HUMAN     SYT1_CHICK     SYT1_BOVIN     O76850         
 O01715         KPC1_HUMAN     KPC1_RABIT     KPC1_RAT       
 KPC2_BOVIN     KPC2_HUMAN     KPC2_MOUSE     KPC2_RABIT     
 KPCA_MOUSE     P97791         SYT3_RAT       SYT3_MOUSE     
 SY63_DISOM     Q25393         SYT1_CAEEL     SY62_DISOM     
 O61224         SY61_DISOM     KPCA_BOVIN     SYT2_RAT       
 SYT2_MOUSE     Q20354         Q25378         SY65_DROME     
 Q14183         P70611         KPC1_DROME     P70169         
 P70610         Q14184         KPC2_DROME     SYT5_HUMAN     
 SYT5_RAT       RP3A_BOVIN     RP3A_RAT       O62567         
 O42573         Q62746         O43373         YPT7_CAEEL     
 O76570         O17665         UN13_CAEEL     Q62770         
 O14795         Q62769         O16700         O15755         
 Q12466         Q62768         O80558         O48645         
 P92940         Q22413         O76835         SYT4_RAT       
 SYT4_MOUSE     PIPA_DICDI     O43374         YMH2_YEAST     
 O73807         Q15111         Q63693         Q62711         
 P91199         PIP6_HUMAN     PIP6_RAT       Q64048         
 O17232         O75131         
Subfamily:  Codes involving 2 elements
 Subfamily True positives..
 Q62747         YNI7_YEAST     O65279         O08758         
 P91493         O61957         Q24284         O14111         
 Q07724         Q07723         Q15147         O75923         
 Q22372         Q93602         O77793         PIP4_RAT       
 PIP4_HUMAN     PIP4_BOVIN     PA2Y_HUMAN     PA2Y_MOUSE     
 PA2Y_RAT       PA2Y_CHICK     Q62688         Q22366         
 Q14644         Q60790         Q28013         O04042         
 PA2Y_BRARE     O49557         O50006         O17398         
 O04823         Q62807         O49951         P97610         
 O48544         O00750         


  PROTEIN TITLES
   KPCG_RABIT       PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) (DELTA
   KPCG_MOUSE       PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) - MUS 
   KPCG_HUMAN       PROTEIN KINASE C, GAMMA TYPE (EC 2.7.1.-) (PKC-GAMMA) - HOMO
   P90981           PROTEIN KINASE C2 B ISOFORM - CAENORHABDITIS ELEGANS.
   P90980           PROTEIN KINASE C2 A ISOFORM - CAENORHABDITIS ELEGANS.
   Q19025           SIMILAR TO PROTEIN KINASE C - CAENORHABDITIS ELEGANS.
   KPCA_HUMAN       PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - HOMO
   KPCA_RABIT       PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - ORYC
   KPCA_RAT         PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - RATT
   SY65_APLCA       SYNAPTOTAGMIN (P65) - APLYSIA CALIFORNICA (CALIFORNIA SEA HA
   SYT1_RAT         SYNAPTOTAGMIN I (P65) - RATTUS NORVEGICUS (RAT).
   SYT1_MOUSE       SYNAPTOTAGMIN I (P65) - MUS MUSCULUS (MOUSE).
   SYT1_HUMAN       SYNAPTOTAGMIN I (P65) - HOMO SAPIENS (HUMAN).
   SYT1_CHICK       SYNAPTOTAGMIN I (P65) - GALLUS GALLUS (CHICKEN).
   SYT1_BOVIN       SYNAPTOTAGMIN I (P65) - BOS TAURUS (BOVINE).
   O76850           EYE-SPECIFIC PROTEIN KINASE C - CALLIPHORA VICINA (BLUE BLOW
   O01715           PROTEIN KINASE C - HYDRA ATTENUATA (HYDRA) (HYDRA VULGARIS).
   KPC1_HUMAN       PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - HO
   KPC1_RABIT       PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - OR
   KPC1_RAT         PROTEIN KINASE C, BETA-I TYPE (EC 2.7.1.-) (PKC-BETA-1) - RA
   KPC2_BOVIN       PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - B
   KPC2_HUMAN       PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - H
   KPC2_MOUSE       PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - M
   KPC2_RABIT       PROTEIN KINASE C, BETA-II TYPE (EC 2.7.1.-) (PKC-BETA-2) - O
   KPCA_MOUSE       PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - MUS 
   P97791           SYNAPTOTAGMIN 3 - MUS MUSCULUS (MOUSE).
   SYT3_RAT         SYNAPTOTAGMIN III - RATTUS NORVEGICUS (RAT).
   SYT3_MOUSE       SYNAPTOTAGMIN III (SYTIII) - MUS MUSCULUS (MOUSE).
   SY63_DISOM       SYNAPTOTAGMIN C (SYNAPTIC VESICLE PROTEIN O-P65-C) - DISCOPY
   Q25393           SYNAPTOTAGMIN - LOLIGO PEALEII (LONGFIN SQUID).
   SYT1_CAEEL       SYNAPTOTAGMIN I - CAENORHABDITIS ELEGANS.
   SY62_DISOM       SYNAPTOTAGMIN B (SYNAPTIC VESICLE PROTEIN O-P65-B) - DISCOPY
   O61224           SERINE/THREONINE PROTEIN KINASE - SYCON RAPHANUS.
   SY61_DISOM       SYNAPTOTAGMIN A (SYNAPTIC VESICLE PROTEIN O-P65-A) - DISCOPY
   KPCA_BOVIN       PROTEIN KINASE C, ALPHA TYPE (EC 2.7.1.-) (PKC-ALPHA) - BOS 
   SYT2_RAT         SYNAPTOTAGMIN II - RATTUS NORVEGICUS (RAT).
   SYT2_MOUSE       SYNAPTOTAGMIN II - MUS MUSCULUS (MOUSE).
   Q20354           SIMILAR TO SYNAPTOTAGMIN - CAENORHABDITIS ELEGANS.
   Q25378           PROTEIN KINASE C (EC 2.7.1.-) - LYTECHINUS PICTUS (PAINTED S
   SY65_DROME       SYNAPTOTAGMIN (P65) - DROSOPHILA MELANOGASTER (FRUIT FLY).
   Q14183           DOC2 - HOMO SAPIENS (HUMAN).
   P70611           DOC2B - RATTUS NORVEGICUS (RAT).
   KPC1_DROME       PROTEIN KINASE C, BRAIN ISOZYME (EC 2.7.1.-) (PKC) (DPKC53E(
   P70169           DOC2BETA - MUS MUSCULUS (MOUSE).
   P70610           DOC2A - RATTUS NORVEGICUS (RAT).
   Q14184           DOC2 BETA - HOMO SAPIENS (HUMAN).
   KPC2_DROME       PROTEIN KINASE C, EYE ISOZYME (EC 2.7.1.-) (PKC) (DPKC53E(EY
   SYT5_HUMAN       SYNAPTOTAGMIN V - HOMO SAPIENS (HUMAN).
   SYT5_RAT         SYNAPTOTAGMIN V - RATTUS NORVEGICUS (RAT).
   RP3A_BOVIN       RABPHILIN-3A - BOS TAURUS (BOVINE).
   RP3A_RAT         RABPHILIN-3A - RATTUS NORVEGICUS (RAT).
   O62567           SERINE/THREONINE PROTEIN KINASE - SUBERITES DOMUNCULA.
   O42573           NEDD4 PROTEIN - XENOPUS LAEVIS (AFRICAN CLAWED FROG).
   Q62746           SYNAPTOTAGMIN VI - RATTUS NORVEGICUS (RAT).
   O43373           PAC CLONE DJ0897G10 FROM 7Q11.23-Q21.1, COMPLETE SEQUENCE - 
   YPT7_CAEEL       HYPOTHETICAL 111.7 KD PROTEIN F37A4.7 IN CHROMOSOME III - CA
   O76570           F54G2.1 PROTEIN - CAENORHABDITIS ELEGANS.
   O17665           UNC-13 PROTEIN - CAENORHABDITIS ELEGANS.
   UN13_CAEEL       PHORBOL ESTER/DIACYLGLYCEROL-BINDING PROTEIN UNC-13 - CAENOR
   Q62770           MUNC13-3 - RATTUS NORVEGICUS (RAT).
   O14795           MUNC13 - HOMO SAPIENS (HUMAN).
   Q62769           MUNC13-2 - RATTUS NORVEGICUS (RAT).
   O16700           R12A1.2 PROTEIN - CAENORHABDITIS ELEGANS.
   O15755           R2005 - DICTYOSTELIUM DISCOIDEUM (SLIME MOLD).
   Q12466           CHROMOSOME XV READING FRAME ORF YOR086C - SACCHAROMYCES CERE
   Q62768           MUNC13-1 - RATTUS NORVEGICUS (RAT).
   O80558           T22J18.21 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
   O48645           CLB1 - LYCOPERSICON ESCULENTUM (TOMATO).
   P92940           CALB PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
   Q22413           HYPOTHETICAL 95.4 KD PROTEIN.
   O76835           T12A2.15 PROTEIN - CAENORHABDITIS ELEGANS.
   SYT4_RAT         SYNAPTOTAGMIN IV - RATTUS NORVEGICUS (RAT).
   SYT4_MOUSE       SYNAPTOTAGMIN IV - MUS MUSCULUS (MOUSE).
   PIPA_DICDI       1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE (E
   O43374           SIMILAR TO GTPASE-ACTIVATING PROTEINS - HOMO SAPIENS (HUMAN)
   YMH2_YEAST       HYPOTHETICAL 171.1 KD PROTEIN IN RPL6A-DAK1 INTERGENIC REGIO
   O73807           HYPOTHETICAL 109.2 KD PROTEIN - FUGU RUBRIPES (JAPANESE PUFF
   Q15111           PHOSPHOLIPASE C - HOMO SAPIENS (HUMAN).
   Q63693           PHODPHOLIPASE C DELTA4 - RATTUS NORVEGICUS (RAT).
   Q62711           PHOSPHOLIPASE C DELTA-4 - RATTUS NORVEGICUS (RAT).
   P91199           SIMILARITY TO C2 DOMAINS - CAENORHABDITIS ELEGANS.
   PIP6_HUMAN       1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DE
   PIP6_RAT         1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DE
   Q64048           PHOSPHOLIPASE C DELTA - RATTUS NORVEGICUS (RAT).
   O17232           K10F12.3 PROTEIN - CAENORHABDITIS ELEGANS.
   O75131           KIAA0636 PROTEIN - HOMO SAPIENS (HUMAN).
 
   Q62747           SYNAPTOTAGMIN VII - RATTUS NORVEGICUS (RAT).
   YNI7_YEAST       HYPOTHETICAL 132.5 KD PROTEIN IN TOP2-MKT1 INTERGENIC REGION
   O65279           F6N23.8 PROTEIN - ARABIDOPSIS THALIANA (MOUSE-EAR CRESS).
   O08758           NEDD-4 - MUS MUSCULUS (MOUSE).
   P91493           SIMILAR TO THE C2 DOMAINS OF SYNAPTOTAGMINS - CAENORHABDITIS
   O61957           B0348.3 PROTEIN - CAENORHABDITIS ELEGANS.
   Q24284           PLC-GAMMA D - DROSOPHILA MELANOGASTER (FRUIT FLY).
   O14111           PUTATIVE PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME C31G5.15
   Q07724           1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BE
   Q07723           1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BE
   Q15147           PHOSPHOLIPASE C BETA 4 - HOMO SAPIENS (HUMAN).
   O75923           DYSFERLIN - HOMO SAPIENS (HUMAN).
   Q22372           T10B10.5 PROTEIN - CAENORHABDITIS ELEGANS.
   Q93602           F26D10.4.
   O77793           CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE 
   PIP4_RAT         1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GA
   PIP4_HUMAN       1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GA
   PIP4_BOVIN       1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GA
   PA2Y_HUMAN       CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE 
   PA2Y_MOUSE       CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE 
   PA2Y_RAT         CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE 
   PA2Y_CHICK       CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE 
   Q62688           130KDA-INS(1,4,5)P3 BINDING PROTEIN - RATTUS NORVEGICUS (RAT
   Q22366           HYPOTHETICAL 95.0 KD PROTEIN SIMILAR TO C2 DOMAIN OF PROTEIN
   Q14644           INS P4-BINDING PROTEIN - HOMO SAPIENS (HUMAN).
   Q60790           RAS P21 PROTEIN ACTIVATOR 3 (BRAIN-ENRICHED GTPASE-ACTIVATIN
   Q28013           R-RAS GTPASE ACTIVATING PROTEIN - BOS TAURUS (BOVINE).
   O04042           HYPOTHETICAL 71.0 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-E
   PA2Y_BRARE       CYTOSOLIC PHOSPHOLIPASE A2 (CPLA2) [INCLUDES: PHOSPHOLIPASE 
   O49557           HYPOTHETICAL 41.0 KD PROTEIN - ARABIDOPSIS THALIANA (MOUSE-E
   O50006           FUNGAL ELICITOR IMMEDIATE EARLY RESPONSIVE (OS-FIERG2) - ORY
   O17398           F52H2.7 PROTEIN - CAENORHABDITIS ELEGANS.
   O04823           HYPOTHETICAL 18.8 KD PROTEIN - SPOROBOLUS STAPFIANUS.
   Q62807           B/K PROTEIN - RATTUS NORVEGICUS (RAT).
   O49951           PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C (EC 3.1.4.11) (1-P
   P97610           SRG1 - RATTUS NORVEGICUS (RAT).
   O48544           PHOSPHOLIPASE D-GAMMA (EC 3.1.4.4) (LIPOPHOSPHODIESTERASE II
   O00750           PHOSPHOINOSITIDE 3-KINASE (EC 2.7.1.137) (1-PHOSPHATIDYLINOS

SCAN HISTORY OWL26_0 3 500 NSINGLE SPTR37_9f 2 500 NSINGLE INITIAL MOTIF SETS C2DOMAIN1 Length of motif = 13 Motif number = 1 C2 domain motif I - 1 PCODE ST INT PNGLSDPYVKVKL KPC1_DROME 197 197 SNGFSDPYVKIYL SYT3_RAT 329 329 MGGTSDPYVKVFL SYT1_RAT 173 173 MGGTSDPYVKVFL SYT2_RAT 174 174 PNGLSDPYVKLKL KPCA_HUMAN 188 188 PNGLSDPYVKLKL KPCG_RAT 188 188 KTGKSDPYVTAQV UN13_CAEEL 754 754 TNGFSDPYIAVQM KPC2_DROME 223 223 QSMTSDPYIKMTI SYT4_MOUSE 186 186 SERSVRTYVEVEL PIP2_HUMAN 691 691 SDKKVGTYVEVDM PIP1_BOVIN 689 689 GRGIVCPFVEIEV PIP4_BOVIN 1104 1104 C2DOMAIN2 Length of motif = 14 Motif number = 2 C2 domain motif II - 1 PCODE ST INT ACLNPVWNETLTYD KPC1_DROME 226 16 KTLNPIFNETFQFS SYT3_RAT 356 14 KTLNPVFNEQFTFK SYT1_RAT 200 14 KTLNPAFNETFTFK SYT2_RAT 201 14 STLNPQWNESFTFK KPCA_HUMAN 217 16 ATLNPVWNETFVFN KPCG_RAT 217 16 QELNPVWNEKFHFE UN13_CAEEL 778 11 KNLNPVFNETFTFE KPC2_DROME 252 16 KTLDPVFGETFTFY SYT4_MOUSE 213 14 NSINPVWKEEPFVF PIP2_HUMAN 723 19 NAVNPIWEEEPIVF PIP1_BOVIN 721 19 NGLNPVWPAKPFHF PIP4_BOVIN 1134 17 C2DOMAIN3 Length of motif = 9 Motif number = 3 C2 domain motif III - 1 PCODE ST INT ILIEVWDWD KPC1_DROME 249 9 LHFSVYDFD SYT3_RAT 380 10 LVMAVYDFD SYT1_RAT 224 10 LVMAIYDFD SYT2_RAT 225 10 LSVEIWDWD KPCA_HUMAN 240 9 LSVEVWDWD KPCG_RAT 240 9 IKVRVWDED UN13_CAEEL 799 7 LLIEVWDWD KPC2_DROME 275 9 LHFTVLSFD SYT4_MOUSE 238 11 LRVAVMEEG PIP2_HUMAN 747 10 LRIAVYEEG PIP1_BOVIN 745 10 LRFVVYEED PIP4_BOVIN 1157 9 FINAL MOTIF SETS C2DOMAIN1 Length of motif = 13 Motif number = 1 C2 domain motif I - 2 PCODE ST INT PNGLSDPYVKLKL KPCG_RABIT 188 188 PNGLSDPYVKLKL KPCG_MOUSE 188 188 PNGLSDPYVKLKL KPCG_HUMAN 188 188 PNGLSDPYVKWKL P90981 190 190 PNGLSDPYVKWKL P90980 190 190 PNGLSDPYVKCKL Q19025 255 255 PNGLSDPYVKLKL KPCA_HUMAN 188 188 PNGLSDPYVKLKL KPCA_RABIT 188 188 PNGLSDPYVKLKL KPCA_RAT 188 188 MSGTSDPYVKVYL SY65_APLCA 183 183 MGGTSDPYVKVFL SYT1_RAT 173 173 MGGTSDPYVKVFL SYT1_MOUSE 173 173 MGGTSDPYVKVFL SYT1_HUMAN 174 174 MGGTSDPYVKVFL SYT1_CHICK 176 176 MGGTSDPYVKVFL SYT1_BOVIN 174 174 TNGLSDPYVAVQL O76850 208 208 PNGQSDPYVKLKL O01715 189 189 PNGLSDPYVKLKL KPC1_HUMAN 188 188 PNGLSDPYVKLKL KPC1_RABIT 188 188 PNGLSDPYVKLKL KPC1_RAT 188 188 PNGLSDPYVKLKL KPC2_BOVIN 188 188 PNGLSDPYVKLKL KPC2_HUMAN 188 188 PNGLSDPYVKLKL KPC2_MOUSE 188 188 PNGLSDPYVKLKL KPC2_RABIT 188 188 PNGLSDPYVKLKL KPCA_MOUSE 188 188 SNGFSDPYVKIYL P97791 328 328 SNGFSDPYVKIYL SYT3_RAT 329 329 SNGFSDPYVKIYL SYT3_MOUSE 328 328 ANGFSDPYVKIYL SY63_DISOM 268 268 MSGTSDPYVKVYL Q25393 180 180 MSGTSDPYVKLYL SYT1_CAEEL 191 191 MGGTSDPYVKVFL SY62_DISOM 191 191 ANGLADPYVKLWL O61224 198 198 VGGTSDPYVKVFV SY61_DISOM 179 179 PNGLSDPYVKLKL KPCA_BOVIN 188 188 MGGTSDPYVKVFL SYT2_RAT 174 174 MGGTSDPYVKVFL SYT2_MOUSE 174 174 VGGSSDPYVKIYL Q20354 136 136 PNGLSDPFVKLKL Q25378 179 179 MGGTSDPYVKVYL SY65_DROME 224 224 VNGYSDPYVKTYL Q14183 283 283 VNGYSDPYVKTYL P70611 286 286 PNGLSDPYVKVKL KPC1_DROME 197 197 ANGYSDPYVKTYL P70169 298 298 ANGYSDPYVKTYL P70610 298 298 ANGYSDPYVKTYL Q14184 298 298 TNGFSDPYIAVQM KPC2_DROME 223 223 LGGSSDPYVRVYL SYT5_HUMAN 140 140 LGGSSDPYVSVYL SYT5_RAT 140 140 ANGYSDPFVKLWL RP3A_BOVIN 592 592 ANGYSDPFVKLWL RP3A_RAT 572 572 ANGLADPYVKLRL O62567 182 182 IFGASDPYVKLSL O42573 34 34 ITGYSDPYVKVSL Q62746 394 394 NNGYSDPFVKVYL O43373 155 155 SNGFSDPYVKFHL YPT7_CAEEL 774 774 SNGLSDPFVVIEI O76570 1066 1066 KTGKSDPYVTAQV O17665 832 832 KTGKSDPYVTAQV UN13_CAEEL 835 835 KTGSSDPYVTVQV Q62770 1230 1230 KTGSSDPYVTVQV O14795 617 617 KTGSSDPYVTVQV Q62769 993 993 KGVTVDPYVKMYL O16700 57 57 IGGTSDPYVKIKS O15755 233 233 LNGYSDPYLKYYI Q12466 1009 1009 KTGSSDPYVTVQV Q62768 706 706 VSGSLDPYVEVKL O80558 65 65 MIGKSDPYAVVHI O48645 279 279 LIGKSDPYATIYI P92940 263 263 KKGKSDPYAEIQV Q22413 326 326 KKGKSDPYAEIQV O76835 326 326 QSMTSDPYIKMTI SYT4_RAT 186 186 QSMTSDPYIKMTI SYT4_MOUSE 186 186 KGEVIDPYVTLSI PIPA_DICDI 694 694 RNGTSDPFVRVRY O43374 173 173 RNGYSDPFVHIFV YMH2_YEAST 1151 1151 IDGKSDPYAVLRV O73807 366 366 KGDVIDPYVCIEI Q15111 644 644 ETTVVDPLVRVEL Q63693 656 656 ETTVVDPLVRVEL Q62711 657 657 FGGKSDPFAVLEL P91199 462 462 KNSIVDPKVTVEI PIP6_HUMAN 648 648 KNSIVDPKVIVEI PIP6_RAT 648 648 KNSIVDPKVIVEI Q64048 648 648 KGDSADPFVVVEV O17232 680 680 IGSKSDPLCVLFL O75131 23 23 C2DOMAIN2 Length of motif = 14 Motif number = 2 C2 domain motif II - 2 PCODE ST INT ATLNPVWNETFVFN KPCG_RABIT 217 16 ATLNPVWNETFVFN KPCG_MOUSE 217 16 ATLNPVWNETFVFN KPCG_HUMAN 217 16 ATLNPQWNETFTYK P90981 220 17 ATLNPQWNETFTYK P90980 220 17 ATLNPQWNETFTYK Q19025 285 17 STLNPQWNESFTFK KPCA_HUMAN 217 16 STLNPQWNESFTFK KPCA_RABIT 217 16 STLNPQWNESFTFK KPCA_RAT 217 16 KTLNPVFNESFTFK SY65_APLCA 210 14 KTLNPVFNEQFTFK SYT1_RAT 200 14 KTLNPVFNEQFTFK SYT1_MOUSE 200 14 KTLNPVFNEQFTFK SYT1_HUMAN 201 14 KTLNPVFNEQFTFK SYT1_CHICK 203 14 KTLNPVFNEQFTFK SYT1_BOVIN 201 14 KNLNPVFNETFTFD O76850 237 16 KCLNPVWNEKFVYK O01715 217 15 CSLNPEWNETFRFQ KPC1_HUMAN 217 16 CSLNPEWNETFRFQ KPC1_RABIT 217 16 CSLNPEWNETFRFQ KPC1_RAT 217 16 CSLNPEWNETFRFQ KPC2_BOVIN 217 16 CSLNPEWNETFRFQ KPC2_HUMAN 217 16 CSLNPEWNETFRFQ KPC2_MOUSE 217 16 CSLNPEWNETFRFQ KPC2_RABIT 217 16 SNLNPQWNESFTFK KPCA_MOUSE 217 16 KTLNPIFNETFQFS P97791 355 14 KTLNPIFNETFQFS SYT3_RAT 356 14 KTLNPIFNETFQFS SYT3_MOUSE 355 14 KTLNPIFNETFQFN SY63_DISOM 295 14 KTLNPVFNESFTFK Q25393 207 14 KTLNPVFNETFIFK SYT1_CAEEL 218 14 KTLNPTFNESFVFK SY62_DISOM 218 14 KTLNPVWGEKFSFN O61224 227 16 KTLNPVFNESFIFK SY61_DISOM 206 14 STLNPRWDESFTFK KPCA_BOVIN 217 16 KTLNPAFNETFTFK SYT2_RAT 201 14 KTLNPAFNETFTFK SYT2_MOUSE 201 14 KTLNPYYNESFQFK Q20354 165 16 GSLNPTWGESFDFN Q25378 208 16 KTLSPVFNETFTFK SY65_DROME 251 14 KTLNPEFNEEFFYE Q14183 312 16 KTLNPEFNEEFFYE P70611 315 16 ACLNPVWNETLTYD KPC1_DROME 226 16 KTLNPEFNEEFCYE P70169 327 16 KTLNPEFNEEFCYE P70610 327 16 KTLNPEFNEEFCYE Q14184 327 16 KNLNPVFNETFTFE KPC2_DROME 252 16 QTLNPHFGETFAFK SYT5_HUMAN 167 14 QTLNPHFGETFAFK SYT5_RAT 167 14 KTLNPEFNEEFFYD RP3A_BOVIN 621 16 KTLNPEFNEEFFYD RP3A_RAT 601 16 KTLEPKFEEDFFYD O62567 213 18 KTLNPKWNEEFFFR O42573 65 18 NTLNPVYNEAIIFD Q62746 423 16 KSLNPEWNQTVIYK O43373 184 16 KTLNPEWNEEMSYY YPT7_CAEEL 803 16 KSLNPIFDETFEFH O76570 1097 18 QELNPVWNEKFHFE O17665 856 11 QELNPVWNEKFHFE UN13_CAEEL 859 11 GNLNPVWDEKFYFE Q62770 1254 11 GNLNPVWEEKFHFE O14795 641 11 GNLNPVWEEKFHFE Q62769 1017 11 KTNDPEFNEMFSFD O16700 84 14 KCLNPVWEETLAVE O15755 259 13 KTLNPKWNDEGTIQ Q12466 1036 14 GNLNPVWEENFHFE Q62768 730 11 KNSNPIWKQIFAFS O80558 89 11 NNLNPVWDQTFELI O48645 304 12 NNLNPVWDQTFELI P92940 288 12 DDLNPIWNEYFEAV Q22413 350 11 DDLNPIWNEYFEAV O76835 350 11 KTLDPVFDETFTFY SYT4_RAT 213 14 KTLDPVFGETFTFY SYT4_MOUSE 213 14 NGFNPHWGEEFEFP PIPA_DICDI 724 17 KSCYPRWNETFEFE O43374 197 11 KTLDPVWNEDAKIP YMH2_YEAST 1176 12 SNLNPQWREMYEVI O73807 390 11 NSDNPIFDETFEFQ Q15111 674 17 NGINPYWGETFYFQ Q63693 686 17 NGINPYWGETFYFQ Q62711 687 17 KTLSPSWNKIYTFA P91199 486 11 NGFNPWWDTEFAFE PIP6_HUMAN 678 17 NGFNPRWDMEFEFE PIP6_RAT 678 17 NGFNPRWDMEFEFE Q64048 678 17 DSINPSFDESFQFQ O17232 710 17 NCLNPQFSKTFIID O75131 53 17 C2DOMAIN3 Length of motif = 9 Motif number = 3 C2 domain motif III - 2 PCODE ST INT LSVEVWDWD KPCG_RABIT 240 9 LSVEVWDWD KPCG_MOUSE 240 9 LSVEVWDWD KPCG_HUMAN 240 9 LSIEVWDWD P90981 243 9 LSIEVWDWD P90980 243 9 LSIEVWDWD Q19025 308 9 LSVEIWDWD KPCA_HUMAN 240 9 LSVEIWDWD KPCA_RABIT 240 9 LSVEIWDWD KPCA_RAT 240 9 LTFAVYDFD SY65_APLCA 234 10 LVMAVYDFD SYT1_RAT 224 10 LVMAVYDFD SYT1_MOUSE 224 10 LVMAVYDFD SYT1_HUMAN 225 10 LVMAVYDFD SYT1_CHICK 227 10 LVMAVYDFD SYT1_BOVIN 225 10 LLVEVWDWD O76850 260 9 LCIEVWDWD O01715 240 9 LSVEIWDWD KPC1_HUMAN 240 9 LSVEIWDWD KPC1_RABIT 240 9 LSVEIWDWD KPC1_RAT 240 9 LSVEIWDWD KPC2_BOVIN 240 9 LSVEIWDWD KPC2_HUMAN 240 9 LSVEIWDWD KPC2_MOUSE 240 9 LSVEIWDWD KPC2_RABIT 240 9 LSVEIWDWD KPCA_MOUSE 240 9 LHFSVYDFD P97791 379 10 LHFSVYDFD SYT3_RAT 380 10 LHFSVYDFD SYT3_MOUSE 379 10 LHFSVYDFD SY63_DISOM 319 10 LVFAIYDFD Q25393 232 11 LVFAIYDFD SYT1_CAEEL 242 10 LMMAVYDFD SY62_DISOM 242 10 LIIEVWDWD O61224 250 9 LVMAVYDFD SY61_DISOM 230 10 LSEEIWDWD KPCA_BOVIN 240 9 LVMAIYDFD SYT2_RAT 225 10 LVMAIYDFD SYT2_MOUSE 225 10 LIVSVWDYD Q20354 189 10 LLVEVWDWD Q25378 231 9 LVFAIFDFD SY65_DROME 276 11 LEVTVWDYD Q14183 336 10 LEVTVWDYD P70611 339 10 ILIEVWDWD KPC1_DROME 249 9 LEVTVWDYD P70169 351 10 LEVTVWDYD P70610 351 10 LEVTVWDYD Q14184 351 10 LLIEVWDWD KPC2_DROME 275 9 LVMAVYDFD SYT5_HUMAN 191 10 LVMAVYDFD SYT5_RAT 191 10 LDISVWDYD RP3A_BOVIN 645 10 LDISVWDYD RP3A_RAT 625 10 LVIEVWDWD O62567 236 9 LLFEVFDEN O42573 86 7 LLISVMDYD Q62746 447 10 LEVTVWDYD O43373 209 11 LRVTVLDRD YPT7_CAEEL 828 11 LHFTVMDHD O76570 1121 10 IKVRVWDED O17665 877 7 IKVRVWDED UN13_CAEEL 880 7 IKVRVWDED Q62770 1275 7 IKVRVWDED O14795 662 7 IKVRVWDED Q62769 1038 7 LQFTVYDFD O16700 108 10 LMFDIYDHD O15755 281 8 LRIKVMDWD Q12466 1058 8 IKVRVLDED Q62768 751 7 LEVTVKDKD O80558 111 8 LFIEVFDKD O48645 326 8 LTVEVFDKD P92940 310 8 LRIELFDED Q22413 372 8 LRIELFDED O76835 372 8 LHFTVLSFD SYT4_RAT 238 11 LHFTVLSFD SYT4_MOUSE 238 11 LLIRVDDKD PIPA_DICDI 746 8 LCVEAWDWD O43374 219 8 VIFNVLDWD YMH2_YEAST 1198 8 LEVEVFDKD O73807 412 8 IRFVVLDDD Q15111 696 8 LRFVVKDYS Q63693 708 8 LRFVVKDYS Q62711 709 8 LQVTIYDED P91199 507 7 IRFLVEDYD PIP6_HUMAN 700 8 VRFMVEDYD PIP6_RAT 700 8 VRFMVEDYD Q64048 700 8 VRFLVLDDD O17232 732 8 LKFGVYDID O75131 75 8

User query: Display/Full Code "C2DOMAIN"