WORKLIST ENTRIES (1):
ALKEXNUCLASE View alignment Alphaherpesvirus alkaline exonuclease signature
Type of fingerprint: COMPOUND with 6 elements
Links:
INTERPRO; IPR001616
Creation date 26-JUN-1998; UPDATE 06-JUN-1999
1. TELFORD, E.A., WATSON, M.S., MCBRIDE, K. AND DAVISON, A.J.
The DNA sequence of equine herpesvirus-1.
VIROLOGY 189 304-316 (1992).
2. DRAPER, K.G., DEVI-RAO, G., COSTA, R.H., BLAIR, E.D., THOMPSON, R.L.
AND WAGNER, E.K.
Characterization of the genes encoding herpes simplex virus type 1 and
type 2 alkaline exonucleases and overlapping proteins.
J.VIROL. 57 1023-1036 (1986).
Equine herpesvirus-1 is a respiratory virus capable of causing abortion and
neurological disease. Its complete DNA sequence has been determined [1] and
the constituent genes found to be arranged co-linearly with those in the
genomes of other alphaherpesviruses, namely varicella-zoster virus and
herpes simplex virus type-1 (HSV-1) [1]. Comparisons of the predicted amino
acid sequences have allowed functions of many equine herpesvirus 1 proteins
to be inferred.
For example, detailed analysis of HSV-1 and HSV-2 DNA has revealed an open
reading frame sufficient to encode 626 amino acids for the HSV-1 alkaline
exonuclease (620 amino acids for HSV-2) [2]. Comparison of the predicted
amino acid sequences of the viral enzymes has revealed significant
differences in the N-terminal portions of the proteins; nevertheless, their
three-dimensional structures are believed to be similar.
ALKEXNUCLASE is a 6-element fingerprint that provides a signature for the
alphaherpesvirus alkaline exonuclease. The fingerprint was derived from an
initial alignment of 5 sequences: the motifs were drawn from conserved
regions spanning the C-terminal half of the alignment. Three iterations
on OWL30.2 were required to reach convergence, at which point a true set
comprising 19 sequences was identified. A single partial match was also
found, JC5169, a pseudorabies virus alkaline nuclease that matches motifs
1,4,5 and 6.
An update on SPTR37_9f identified a true set of 21 sequences, and 1
partial match.
SUMMARY INFORMATION
21 codes involving 6 elements
0 codes involving 5 elements
1 codes involving 4 elements
0 codes involving 3 elements
0 codes involving 2 elements
COMPOSITE FINGERPRINT INDEX
6| 21 21 21 21 21 21
5| 0 0 0 0 0 0
4| 1 0 0 1 1 1
3| 0 0 0 0 0 0
2| 0 0 0 0 0 0
--+-------------------------------
| 1 2 3 4 5 6
True positives..
Q68979 Q68978 EXON_HSV11 O39290
EXON_HSV2 P89435 EXON_HSVEB Q85039
Q65572 EXON_HSV6Z EXON_VZVD O41954
Q66641 O40930 P88925 O36386
EXON_EBV EXON_HSV6U EXON_HSVSA EXON_HCMVA
EXON_HSV7J
Subfamily: Codes involving 4 elements
Subfamily True positives..
Q87066
PROTEIN TITLES
Q68979 1.9KD ORF - HUMAN HERPESVIRUS 1.
Q68978 ALKALINE EXONUCLEASE - HUMAN HERPESVIRUS 1.
EXON_HSV11 ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
O39290 COUNTERPART OF HSV-1 GENE UL12 AND VZV GENE 48 - EQUINE HERP
EXON_HSV2 ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
P89435 DEOXYRIBONUCLEASE - HERPES SIMPLEX VIRUS (TYPE 2).
EXON_HSVEB ALKALINE EXONUCLEASE (EC 3.1.11.-) - EQUINE HERPESVIRUS TYPE
Q85039 UL12 - PSEUDORABIES VIRUS.
Q65572 DEOXYRIBONUCLEASE - BOVINE HERPESVIRUS 1.
EXON_HSV6Z ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
EXON_VZVD ALKALINE EXONUCLEASE (EC 3.1.11.-) - VARICELLA-ZOSTER VIRUS
O41954 ALKALINE EXONUCLEASE - MURINE HERPESVIRUS 68.
Q66641 DEOXYRIBONUCLEASE - EQUINE HERPESVIRUS 2.
O40930 ORF 37 - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUM
P88925 ORF 37 - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUM
O36386 ALKALINE EXONUCLEASE - ALCELAPHINE HERPESVIRUS 1 (WILDEBEEST
EXON_EBV ALKALINE EXONUCLEASE (EC 3.1.11.-) - EPSTEIN-BARR VIRUS (STR
EXON_HSV6U ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
EXON_HSVSA ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPESVIRUS SAIMIRI (ST
EXON_HCMVA ALKALINE EXONUCLEASE (EC 3.1.11.-) - HUMAN CYTOMEGALOVIRUS (
EXON_HSV7J ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
Q87066 ALKALINE NUCLEASE - PSEUDORABIES VIRUS.
SCAN HISTORY
OWL30_2 3 100 NSINGLE
SPTR37_9f 2 26 NSINGLE
INITIAL MOTIF SETS
ALKEXNUCLASE1 Length of motif = 18 Motif number = 1
Alkaline exonuclease motif I - 1
PCODE ST INT
EAATQNQADCQLWALLRR EXON_HSV2 209 209
EAATQNQADCQLWALLRR EXON_HSV11 219 219
EAQTRDQSESQLWALLRR EXON_HSVEB 111 111
ESETRGQGDNAIWTLLRR EXON_VZVD 127 127
EAATRAQSESDLWTLLRR PRVULGNS1 91 91
ALKEXNUCLASE2 Length of motif = 24 Motif number = 2
Alkaline exonuclease motif II - 1
PCODE ST INT
CGVLMDGHTGMVGASLDILVCPRD EXON_HSV2 314 87
CGVLMDGHTGMVGASLDILVCPRD EXON_HSV11 324 87
CGLLMDARTGVVGASLDMLVCDRD EXON_HSVEB 219 90
CGLLIDVRTGLIGASLDVLVCDRD EXON_VZVD 244 99
CGLLLDPRTGMVGASLDLLVCDRD PRVULGNS1 207 98
ALKEXNUCLASE3 Length of motif = 18 Motif number = 3
Alkaline exonuclease motif III - 1
PCODE ST INT
TPLAFYEVKCRAKYAFDP EXON_HSV2 348 10
TPLAFYEVKCRAKYAFDP EXON_HSV11 358 10
TTLDFFEIKCRAKYLFDP EXON_HSVEB 254 11
TDISFFEIKCRAKYLFDP EXON_VZVD 280 12
TEMRFFEIKCRAKYLFSA PRVULGNS1 242 11
ALKEXNUCLASE4 Length of motif = 17 Motif number = 4
Alkaline exonuclease motif IV - 1
PCODE ST INT
RAFIRSIPNPGVRYFAP EXON_HSV2 389 23
RAFIRSIPKPSVRYFAP EXON_HSV11 399 23
RKFLRSIKNPAVEYFAP EXON_HSVEB 294 22
RDFLYTIKNPCVSFFGP EXON_VZVD 321 23
RGFLYSIARPGVEFFEG PRVULGNS1 282 22
ALKEXNUCLASE5 Length of motif = 21 Motif number = 5
Alkaline exonuclease motif V - 1
PCODE ST INT
PIFANPRHPNFKQILVQGYVL EXON_HSV2 480 74
PVFANPRHPNFKQILVQGYVL EXON_HSV11 490 74
PVFANPRHPNFKQILVQAYVL EXON_HSVEB 385 74
PVFANPRHANFKQIAVQTYVL EXON_VZVD 411 73
PVFANPRHANFRQILVQSYVV PRVULGNS1 372 73
ALKEXNUCLASE6 Length of motif = 19 Motif number = 6
Alkaline exonuclease motif VI - 1
PCODE ST INT
ILPDQAVPIALIITPVRVE EXON_HSV2 553 52
ILPNQAVPIALIITPVRID EXON_HSV11 559 48
VHSSCAIPILLFVTPVIVD EXON_HSVEB 452 46
IPPHCAVPVIAVLTPIEVD EXON_VZVD 478 46
VPPACAVPVLLIVTPVSVC PRVULGNS1 430 37
FINAL MOTIF SETS
ALKEXNUCLASE1 Length of motif = 18 Motif number = 1
Alkaline exonuclease motif I - 2
PCODE ST INT
EAATQNQADCQLWALLRR EXON_HSV11 219 219
EAATQNQADCQLWALLRR Q68978 219 219
EAATQNQADCQLWALLRR Q68979 93 93
EAQTRDQSESQLWALLRR O39290 168 168
EAATQNQADCQLWALLRR EXON_HSV2 209 209
EAATQNQADCQLWALLRR P89435 209 209
EAQTRDQSESQLWALLRR EXON_HSVEB 111 111
EAATRAQSESDLWTLLRR Q85039 91 91
EAATRGQAACDLWWLLRR Q65572 84 84
ERETRGQSENPLWHALRR EXON_HSV6Z 123 123
ESETRGQGDNAIWTLLRR EXON_VZVD 127 127
EALTRGQQDNELWDILRD O41954 121 121
EAITRGQYENNLWEIFRD Q66641 146 146
ERATSSQSLNPVWDALRD O40930 123 123
ERATSSQSLNPVWDALRD P88925 123 123
ERLTRGQGENVLWEVLRD O36386 117 117
ESMTRGQSENLMWDILRN EXON_EBV 107 107
ERETRGQSENPLWHALRK EXON_HSV6U 123 123
EEVTRGQYLNSLWDALRD EXON_HSVSA 119 119
EKESRGQSRNSVWHLLRM EXON_HCMVA 148 148
ERETRGQSTNPLWHAMRK EXON_HSV7J 114 114
ALKEXNUCLASE2 Length of motif = 24 Motif number = 2
Alkaline exonuclease motif II - 2
PCODE ST INT
CGVLMDGHTGMVGASLDILVCPRD EXON_HSV11 324 87
CGVLMDGHTGMVGASLDILVCPRD Q68978 324 87
CGVLMDGHTGMVGASLDILVCPRD Q68979 198 87
CGLLIDARTGVVGASLDMLVCDRD O39290 276 90
CGVLMDGHTGMVGASLDILVCPRD EXON_HSV2 314 87
CGVLMDGHTGMVGASLDILVCPRD P89435 314 87
CGLLMDARTGVVGASLDMLVCDRD EXON_HSVEB 219 90
CGLLLDPRTGMVGASLDLLVCDRD Q85039 207 98
CGLLIDPRTGALGASIDMLVCDRD Q65572 202 100
LGLLLDPSSGVFGASLDACFGISF EXON_HSV6Z 197 56
CGLLIDVRTGLIGASLDVLVCDRD EXON_VZVD 244 99
CGFLPSAIDGIFGVSLDTAFNVFT O41954 203 64
VGFLQSPKDGIFGVSLDMCANVSV Q66641 228 64
YGFMQSPQNGIFGVSLDFAANVKT O40930 205 64
YGFMQSPQNGIFGVSLDFAANVKT P88925 205 64
FGFMLSPNDGIFGVSLDMCTNASM O36386 200 65
FGFMISPTDGIFGVSLDLCVNVES EXON_EBV 187 62
LGLLLDPSSGVFGASLDACFGISF EXON_HSV6U 197 56
CGFMQSPLDGIFGVSLDYCTNVET EXON_HSVSA 202 65
LGLLIDPTSGLLGASMDLCFGVLK EXON_HCMVA 238 72
LGLLLDPSSGVFGASIDSYYGISF EXON_HSV7J 189 57
ALKEXNUCLASE3 Length of motif = 18 Motif number = 3
Alkaline exonuclease motif III - 2
PCODE ST INT
TPLAFYEVKCRAKYAFDP EXON_HSV11 358 10
TPLAFYEVKCRAKYAFDP Q68978 358 10
TPLAFYEVKCRAKYAFDP Q68979 232 10
TTLDFFEIKCRAKYLFDP O39290 311 11
TPLAFYEVKCRAKYAFDP EXON_HSV2 348 10
TPLAFYEVKCRAKYAFDP P89435 348 10
TTLDFFEIKCRAKYLFDP EXON_HSVEB 254 11
TEMRFFEIKCRAKYLFSA Q85039 242 11
TALGVFEIKCRAKYAFDP Q65572 237 11
EKALIFEIKFRYKYLRDK EXON_HSV6Z 230 9
TDISFFEIKCRAKYLFDP EXON_VZVD 280 12
PDSIVYEIKSRYKYQFSK O41954 236 9
ADAEIYEIKCRFKYNYSK Q66641 261 9
PNCKVYEIKCRFKYTFAK O40930 238 9
PNCKVYEIKCRFKYTFAK P88925 238 9
STTTIYEIKCRYKYLFSK O36386 233 9
DRSCIYEIKCRFKYLFSK EXON_EBV 219 8
EKALIFEIKFKYKYLRDK EXON_HSV6U 230 9
PDTEVYEIKSRFKYLFDK EXON_HSVSA 235 9
PCARVYEIKCRYKYLRKK EXON_HCMVA 272 10
DKVVIFELKFRYKYLREK EXON_HSV7J 222 9
ALKEXNUCLASE4 Length of motif = 17 Motif number = 4
Alkaline exonuclease motif IV - 2
PCODE ST INT
RAFIRSIPKPSVRYFAP EXON_HSV11 399 23
RAFIRSIPKPSVRYFAP Q68978 399 23
RAFIRSIPKPSVRYFAP Q68979 273 23
RKFLRSIKNPAVEYFAS O39290 351 22
RAFIRSIPNPGVRYFAP EXON_HSV2 389 23
RAFIRSIPNPGVRYFAP P89435 389 23
RKFLRSIKNPAVEYFAP EXON_HSVEB 294 22
RGFLYSIARPGVEFFEG Q85039 282 22
RAFLRSVRRPGVEHCPP Q65572 276 21
SDFILSHPVPAIEFRER EXON_HSV6Z 265 17
RDFLYTIKNPCVSFFGP EXON_VZVD 321 23
IKFINCISRPAVEYVPH O41954 276 22
IRFLSGINRPAVEYVPP Q66641 301 22
KDFFYSISKPAVEYVGL O40930 278 22
KDFFYSISKPAVEYVGL P88925 278 22
IDFIQSIQKPTVEYVSR O36386 273 22
IRFINSIARPTVEYVPD EXON_EBV 259 22
SDFILSHPVPVIEFRER EXON_HSV6U 265 17
IKFIFSVSKPAIEFVPS EXON_HSVSA 275 22
ASLLQSHPVPGVEFRGE EXON_HCMVA 307 17
AKFILSHPIPAIEYREN EXON_HSV7J 257 17
ALKEXNUCLASE5 Length of motif = 21 Motif number = 5
Alkaline exonuclease motif V - 2
PCODE ST INT
PVFANPRHPNFKQILVQGYVL EXON_HSV11 490 74
PVFANPRHPNFKQILVQGYVL Q68978 490 74
PVFANPRHPNFKQILVQGYVL Q68979 364 74
PVFANPRHPNFKQILVQAYVL O39290 442 74
PIFANPRHPNFKQILVQGYVL EXON_HSV2 480 74
PIFANPRHPNFKQILVQGYVL P89435 480 74
PVFANPRHPNFKQILVQAYVL EXON_HSVEB 385 74
PVFANPRHANFRQILVQSYVV Q85039 372 73
PLFANPRHANFKQILVQSYVL Q65572 369 76
NVFVNPKHRYFFQSLLQQYVM EXON_HSV6Z 356 74
PVFANPRHANFKQIAVQTYVL EXON_VZVD 411 73
DVFVNPAHNYFYQVALQNMVV O41954 362 69
DVFINPEHSYFYQILLQYKVV Q66641 387 69
NLFVNVRHSYFYQVLLQSSIV O40930 364 69
NLFVNVRHSYFYQVLLQSSIV P88925 364 69
DIYINPRHAYYHQCMLQYKIV O36386 360 70
NIFINPRHNYFYQVLLQYKIV EXON_EBV 345 69
NVFVNPKHRYFFQSLLQQYVM EXON_HSV6U 356 74
GIFMNPRHTYFYQVALQHRVV EXON_HSVSA 361 69
PAFVNPRHQYYFQMLIQQYVL EXON_HCMVA 452 128
DAFINPRHRYYFQSILQQYVM EXON_HSV7J 348 74
ALKEXNUCLASE6 Length of motif = 19 Motif number = 6
Alkaline exonuclease motif VI - 2
PCODE ST INT
ILPNQAVPIALIITPVRID EXON_HSV11 559 48
ILPNQAVPIALIITPVRID Q68978 559 48
ILPNQAVPIALIITPVRID Q68979 433 48
VHSSCAIPILLIVTPVIVD O39290 509 46
ILPDQAVPIALIITPVRVE EXON_HSV2 553 52
ILPDQAVPIALIITPVRVE P89435 553 52
VHSSCAIPILLFVTPVIVD EXON_HSVEB 452 46
VPPACAVPVLLIVTPVSVC Q85039 430 37
VPREGAVPVLLIATPVVVD Q65572 431 41
EYIEEEIPLALIVTPVAPN EXON_HSV6Z 423 46
IPPHCAVPVIAVLTPIEVD EXON_VZVD 478 46
LDTTDEIPVALIITPVRIP O41954 427 44
LDSACEIPVLLILTPVYIP Q66641 450 42
LDPHVEIPTLLIVTPVYFP O40930 427 42
LDPHVEIPTLLIVTPVYFP P88925 427 42
VDASVEIPVLLIITPVFVP O36386 426 45
LDASVEIPVAVLVTPVVLP EXON_EBV 411 45
EYIEEEIPLALIVTPVAPN EXON_HSV6U 423 46
LEKTVEIPVFIIITPVYIP EXON_HSVSA 424 42
VFHCDHIPLLLIVTPVVFD EXON_HCMVA 519 46
EYLEEEIPLILLITPITID EXON_HSV7J 415 46
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