WORKLIST ENTRIES (1):

ALKEXNUCLASE View alignment     Alphaherpesvirus alkaline exonuclease signature
 Type of fingerprint: COMPOUND with 6  elements
Links:
   INTERPRO; IPR001616

 Creation date 26-JUN-1998; UPDATE 06-JUN-1999

   1. TELFORD, E.A., WATSON, M.S., MCBRIDE, K. AND DAVISON, A.J.
   The DNA sequence of equine herpesvirus-1. 
   VIROLOGY 189 304-316 (1992). 

   2. DRAPER, K.G., DEVI-RAO, G., COSTA, R.H., BLAIR, E.D., THOMPSON, R.L.
   AND WAGNER, E.K.
   Characterization of the genes encoding herpes simplex virus type 1 and 
   type 2 alkaline exonucleases and overlapping proteins. 
   J.VIROL. 57 1023-1036 (1986).

   Equine herpesvirus-1 is a respiratory virus capable of causing abortion and
   neurological disease. Its complete DNA sequence has been determined [1] and
   the constituent genes found to be arranged co-linearly with those in the
   genomes of other alphaherpesviruses, namely varicella-zoster virus and 
   herpes simplex virus type-1 (HSV-1) [1]. Comparisons of the predicted amino
   acid sequences have allowed functions of many equine herpesvirus 1 proteins
   to be inferred. 
  
   For example, detailed analysis of HSV-1 and HSV-2 DNA has revealed an open 
   reading frame sufficient to encode 626 amino acids for the HSV-1 alkaline
   exonuclease (620 amino acids for HSV-2) [2]. Comparison of the predicted
   amino acid sequences of the viral enzymes has revealed significant
   differences in the N-terminal portions of the proteins; nevertheless, their
   three-dimensional structures are believed to be similar. 
  
   ALKEXNUCLASE is a 6-element fingerprint that provides a signature for the
   alphaherpesvirus alkaline exonuclease. The fingerprint was derived from an 
   initial alignment of 5 sequences: the motifs were drawn from conserved
   regions spanning the C-terminal half of the alignment. Three iterations
   on OWL30.2 were required to reach convergence, at which point a true set
   comprising 19 sequences was identified. A single partial match was also
   found, JC5169, a pseudorabies virus alkaline nuclease that matches motifs
   1,4,5 and 6.
  
   An update on SPTR37_9f identified a true set of 21 sequences, and 1
   partial match.

  SUMMARY INFORMATION
     21 codes involving  6 elements
      0 codes involving  5 elements
      1 codes involving  4 elements
      0 codes involving  3 elements
      0 codes involving  2 elements

   COMPOSITE FINGERPRINT INDEX
  
    6|  21   21   21   21   21   21  
    5|   0    0    0    0    0    0  
    4|   1    0    0    1    1    1  
    3|   0    0    0    0    0    0  
    2|   0    0    0    0    0    0  
   --+-------------------------------
     |   1    2    3    4    5    6  

True positives..
 Q68979         Q68978         EXON_HSV11     O39290         
 EXON_HSV2      P89435         EXON_HSVEB     Q85039         
 Q65572         EXON_HSV6Z     EXON_VZVD      O41954         
 Q66641         O40930         P88925         O36386         
 EXON_EBV       EXON_HSV6U     EXON_HSVSA     EXON_HCMVA     
 EXON_HSV7J     
Subfamily:  Codes involving 4 elements
 Subfamily True positives..
 Q87066         


  PROTEIN TITLES
   Q68979           1.9KD ORF - HUMAN HERPESVIRUS 1.
   Q68978           ALKALINE EXONUCLEASE - HUMAN HERPESVIRUS 1.
   EXON_HSV11       ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
   O39290           COUNTERPART OF HSV-1 GENE UL12 AND VZV GENE 48 - EQUINE HERP
   EXON_HSV2        ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
   P89435           DEOXYRIBONUCLEASE - HERPES SIMPLEX VIRUS (TYPE 2).
   EXON_HSVEB       ALKALINE EXONUCLEASE (EC 3.1.11.-) - EQUINE HERPESVIRUS TYPE
   Q85039           UL12 - PSEUDORABIES VIRUS.
   Q65572           DEOXYRIBONUCLEASE - BOVINE HERPESVIRUS 1.
   EXON_HSV6Z       ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
   EXON_VZVD        ALKALINE EXONUCLEASE (EC 3.1.11.-) - VARICELLA-ZOSTER VIRUS 
   O41954           ALKALINE EXONUCLEASE - MURINE HERPESVIRUS 68.
   Q66641           DEOXYRIBONUCLEASE - EQUINE HERPESVIRUS 2.
   O40930           ORF 37 - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUM
   P88925           ORF 37 - KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (KSHV) (HUM
   O36386           ALKALINE EXONUCLEASE - ALCELAPHINE HERPESVIRUS 1 (WILDEBEEST
   EXON_EBV         ALKALINE EXONUCLEASE (EC 3.1.11.-) - EPSTEIN-BARR VIRUS (STR
   EXON_HSV6U       ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
   EXON_HSVSA       ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPESVIRUS SAIMIRI (ST
   EXON_HCMVA       ALKALINE EXONUCLEASE (EC 3.1.11.-) - HUMAN CYTOMEGALOVIRUS (
   EXON_HSV7J       ALKALINE EXONUCLEASE (EC 3.1.11.-) - HERPES SIMPLEX VIRUS (T
 
   Q87066           ALKALINE NUCLEASE - PSEUDORABIES VIRUS.

SCAN HISTORY OWL30_2 3 100 NSINGLE SPTR37_9f 2 26 NSINGLE INITIAL MOTIF SETS ALKEXNUCLASE1 Length of motif = 18 Motif number = 1 Alkaline exonuclease motif I - 1 PCODE ST INT EAATQNQADCQLWALLRR EXON_HSV2 209 209 EAATQNQADCQLWALLRR EXON_HSV11 219 219 EAQTRDQSESQLWALLRR EXON_HSVEB 111 111 ESETRGQGDNAIWTLLRR EXON_VZVD 127 127 EAATRAQSESDLWTLLRR PRVULGNS1 91 91 ALKEXNUCLASE2 Length of motif = 24 Motif number = 2 Alkaline exonuclease motif II - 1 PCODE ST INT CGVLMDGHTGMVGASLDILVCPRD EXON_HSV2 314 87 CGVLMDGHTGMVGASLDILVCPRD EXON_HSV11 324 87 CGLLMDARTGVVGASLDMLVCDRD EXON_HSVEB 219 90 CGLLIDVRTGLIGASLDVLVCDRD EXON_VZVD 244 99 CGLLLDPRTGMVGASLDLLVCDRD PRVULGNS1 207 98 ALKEXNUCLASE3 Length of motif = 18 Motif number = 3 Alkaline exonuclease motif III - 1 PCODE ST INT TPLAFYEVKCRAKYAFDP EXON_HSV2 348 10 TPLAFYEVKCRAKYAFDP EXON_HSV11 358 10 TTLDFFEIKCRAKYLFDP EXON_HSVEB 254 11 TDISFFEIKCRAKYLFDP EXON_VZVD 280 12 TEMRFFEIKCRAKYLFSA PRVULGNS1 242 11 ALKEXNUCLASE4 Length of motif = 17 Motif number = 4 Alkaline exonuclease motif IV - 1 PCODE ST INT RAFIRSIPNPGVRYFAP EXON_HSV2 389 23 RAFIRSIPKPSVRYFAP EXON_HSV11 399 23 RKFLRSIKNPAVEYFAP EXON_HSVEB 294 22 RDFLYTIKNPCVSFFGP EXON_VZVD 321 23 RGFLYSIARPGVEFFEG PRVULGNS1 282 22 ALKEXNUCLASE5 Length of motif = 21 Motif number = 5 Alkaline exonuclease motif V - 1 PCODE ST INT PIFANPRHPNFKQILVQGYVL EXON_HSV2 480 74 PVFANPRHPNFKQILVQGYVL EXON_HSV11 490 74 PVFANPRHPNFKQILVQAYVL EXON_HSVEB 385 74 PVFANPRHANFKQIAVQTYVL EXON_VZVD 411 73 PVFANPRHANFRQILVQSYVV PRVULGNS1 372 73 ALKEXNUCLASE6 Length of motif = 19 Motif number = 6 Alkaline exonuclease motif VI - 1 PCODE ST INT ILPDQAVPIALIITPVRVE EXON_HSV2 553 52 ILPNQAVPIALIITPVRID EXON_HSV11 559 48 VHSSCAIPILLFVTPVIVD EXON_HSVEB 452 46 IPPHCAVPVIAVLTPIEVD EXON_VZVD 478 46 VPPACAVPVLLIVTPVSVC PRVULGNS1 430 37 FINAL MOTIF SETS ALKEXNUCLASE1 Length of motif = 18 Motif number = 1 Alkaline exonuclease motif I - 2 PCODE ST INT EAATQNQADCQLWALLRR EXON_HSV11 219 219 EAATQNQADCQLWALLRR Q68978 219 219 EAATQNQADCQLWALLRR Q68979 93 93 EAQTRDQSESQLWALLRR O39290 168 168 EAATQNQADCQLWALLRR EXON_HSV2 209 209 EAATQNQADCQLWALLRR P89435 209 209 EAQTRDQSESQLWALLRR EXON_HSVEB 111 111 EAATRAQSESDLWTLLRR Q85039 91 91 EAATRGQAACDLWWLLRR Q65572 84 84 ERETRGQSENPLWHALRR EXON_HSV6Z 123 123 ESETRGQGDNAIWTLLRR EXON_VZVD 127 127 EALTRGQQDNELWDILRD O41954 121 121 EAITRGQYENNLWEIFRD Q66641 146 146 ERATSSQSLNPVWDALRD O40930 123 123 ERATSSQSLNPVWDALRD P88925 123 123 ERLTRGQGENVLWEVLRD O36386 117 117 ESMTRGQSENLMWDILRN EXON_EBV 107 107 ERETRGQSENPLWHALRK EXON_HSV6U 123 123 EEVTRGQYLNSLWDALRD EXON_HSVSA 119 119 EKESRGQSRNSVWHLLRM EXON_HCMVA 148 148 ERETRGQSTNPLWHAMRK EXON_HSV7J 114 114 ALKEXNUCLASE2 Length of motif = 24 Motif number = 2 Alkaline exonuclease motif II - 2 PCODE ST INT CGVLMDGHTGMVGASLDILVCPRD EXON_HSV11 324 87 CGVLMDGHTGMVGASLDILVCPRD Q68978 324 87 CGVLMDGHTGMVGASLDILVCPRD Q68979 198 87 CGLLIDARTGVVGASLDMLVCDRD O39290 276 90 CGVLMDGHTGMVGASLDILVCPRD EXON_HSV2 314 87 CGVLMDGHTGMVGASLDILVCPRD P89435 314 87 CGLLMDARTGVVGASLDMLVCDRD EXON_HSVEB 219 90 CGLLLDPRTGMVGASLDLLVCDRD Q85039 207 98 CGLLIDPRTGALGASIDMLVCDRD Q65572 202 100 LGLLLDPSSGVFGASLDACFGISF EXON_HSV6Z 197 56 CGLLIDVRTGLIGASLDVLVCDRD EXON_VZVD 244 99 CGFLPSAIDGIFGVSLDTAFNVFT O41954 203 64 VGFLQSPKDGIFGVSLDMCANVSV Q66641 228 64 YGFMQSPQNGIFGVSLDFAANVKT O40930 205 64 YGFMQSPQNGIFGVSLDFAANVKT P88925 205 64 FGFMLSPNDGIFGVSLDMCTNASM O36386 200 65 FGFMISPTDGIFGVSLDLCVNVES EXON_EBV 187 62 LGLLLDPSSGVFGASLDACFGISF EXON_HSV6U 197 56 CGFMQSPLDGIFGVSLDYCTNVET EXON_HSVSA 202 65 LGLLIDPTSGLLGASMDLCFGVLK EXON_HCMVA 238 72 LGLLLDPSSGVFGASIDSYYGISF EXON_HSV7J 189 57 ALKEXNUCLASE3 Length of motif = 18 Motif number = 3 Alkaline exonuclease motif III - 2 PCODE ST INT TPLAFYEVKCRAKYAFDP EXON_HSV11 358 10 TPLAFYEVKCRAKYAFDP Q68978 358 10 TPLAFYEVKCRAKYAFDP Q68979 232 10 TTLDFFEIKCRAKYLFDP O39290 311 11 TPLAFYEVKCRAKYAFDP EXON_HSV2 348 10 TPLAFYEVKCRAKYAFDP P89435 348 10 TTLDFFEIKCRAKYLFDP EXON_HSVEB 254 11 TEMRFFEIKCRAKYLFSA Q85039 242 11 TALGVFEIKCRAKYAFDP Q65572 237 11 EKALIFEIKFRYKYLRDK EXON_HSV6Z 230 9 TDISFFEIKCRAKYLFDP EXON_VZVD 280 12 PDSIVYEIKSRYKYQFSK O41954 236 9 ADAEIYEIKCRFKYNYSK Q66641 261 9 PNCKVYEIKCRFKYTFAK O40930 238 9 PNCKVYEIKCRFKYTFAK P88925 238 9 STTTIYEIKCRYKYLFSK O36386 233 9 DRSCIYEIKCRFKYLFSK EXON_EBV 219 8 EKALIFEIKFKYKYLRDK EXON_HSV6U 230 9 PDTEVYEIKSRFKYLFDK EXON_HSVSA 235 9 PCARVYEIKCRYKYLRKK EXON_HCMVA 272 10 DKVVIFELKFRYKYLREK EXON_HSV7J 222 9 ALKEXNUCLASE4 Length of motif = 17 Motif number = 4 Alkaline exonuclease motif IV - 2 PCODE ST INT RAFIRSIPKPSVRYFAP EXON_HSV11 399 23 RAFIRSIPKPSVRYFAP Q68978 399 23 RAFIRSIPKPSVRYFAP Q68979 273 23 RKFLRSIKNPAVEYFAS O39290 351 22 RAFIRSIPNPGVRYFAP EXON_HSV2 389 23 RAFIRSIPNPGVRYFAP P89435 389 23 RKFLRSIKNPAVEYFAP EXON_HSVEB 294 22 RGFLYSIARPGVEFFEG Q85039 282 22 RAFLRSVRRPGVEHCPP Q65572 276 21 SDFILSHPVPAIEFRER EXON_HSV6Z 265 17 RDFLYTIKNPCVSFFGP EXON_VZVD 321 23 IKFINCISRPAVEYVPH O41954 276 22 IRFLSGINRPAVEYVPP Q66641 301 22 KDFFYSISKPAVEYVGL O40930 278 22 KDFFYSISKPAVEYVGL P88925 278 22 IDFIQSIQKPTVEYVSR O36386 273 22 IRFINSIARPTVEYVPD EXON_EBV 259 22 SDFILSHPVPVIEFRER EXON_HSV6U 265 17 IKFIFSVSKPAIEFVPS EXON_HSVSA 275 22 ASLLQSHPVPGVEFRGE EXON_HCMVA 307 17 AKFILSHPIPAIEYREN EXON_HSV7J 257 17 ALKEXNUCLASE5 Length of motif = 21 Motif number = 5 Alkaline exonuclease motif V - 2 PCODE ST INT PVFANPRHPNFKQILVQGYVL EXON_HSV11 490 74 PVFANPRHPNFKQILVQGYVL Q68978 490 74 PVFANPRHPNFKQILVQGYVL Q68979 364 74 PVFANPRHPNFKQILVQAYVL O39290 442 74 PIFANPRHPNFKQILVQGYVL EXON_HSV2 480 74 PIFANPRHPNFKQILVQGYVL P89435 480 74 PVFANPRHPNFKQILVQAYVL EXON_HSVEB 385 74 PVFANPRHANFRQILVQSYVV Q85039 372 73 PLFANPRHANFKQILVQSYVL Q65572 369 76 NVFVNPKHRYFFQSLLQQYVM EXON_HSV6Z 356 74 PVFANPRHANFKQIAVQTYVL EXON_VZVD 411 73 DVFVNPAHNYFYQVALQNMVV O41954 362 69 DVFINPEHSYFYQILLQYKVV Q66641 387 69 NLFVNVRHSYFYQVLLQSSIV O40930 364 69 NLFVNVRHSYFYQVLLQSSIV P88925 364 69 DIYINPRHAYYHQCMLQYKIV O36386 360 70 NIFINPRHNYFYQVLLQYKIV EXON_EBV 345 69 NVFVNPKHRYFFQSLLQQYVM EXON_HSV6U 356 74 GIFMNPRHTYFYQVALQHRVV EXON_HSVSA 361 69 PAFVNPRHQYYFQMLIQQYVL EXON_HCMVA 452 128 DAFINPRHRYYFQSILQQYVM EXON_HSV7J 348 74 ALKEXNUCLASE6 Length of motif = 19 Motif number = 6 Alkaline exonuclease motif VI - 2 PCODE ST INT ILPNQAVPIALIITPVRID EXON_HSV11 559 48 ILPNQAVPIALIITPVRID Q68978 559 48 ILPNQAVPIALIITPVRID Q68979 433 48 VHSSCAIPILLIVTPVIVD O39290 509 46 ILPDQAVPIALIITPVRVE EXON_HSV2 553 52 ILPDQAVPIALIITPVRVE P89435 553 52 VHSSCAIPILLFVTPVIVD EXON_HSVEB 452 46 VPPACAVPVLLIVTPVSVC Q85039 430 37 VPREGAVPVLLIATPVVVD Q65572 431 41 EYIEEEIPLALIVTPVAPN EXON_HSV6Z 423 46 IPPHCAVPVIAVLTPIEVD EXON_VZVD 478 46 LDTTDEIPVALIITPVRIP O41954 427 44 LDSACEIPVLLILTPVYIP Q66641 450 42 LDPHVEIPTLLIVTPVYFP O40930 427 42 LDPHVEIPTLLIVTPVYFP P88925 427 42 VDASVEIPVLLIITPVFVP O36386 426 45 LDASVEIPVAVLVTPVVLP EXON_EBV 411 45 EYIEEEIPLALIVTPVAPN EXON_HSV6U 423 46 LEKTVEIPVFIIITPVYIP EXON_HSVSA 424 42 VFHCDHIPLLLIVTPVVFD EXON_HCMVA 519 46 EYLEEEIPLILLITPITID EXON_HSV7J 415 46

User query: Display/Full Code "ALKEXNUCLASE"